中国卒中杂志 ›› 2013, Vol. 8 ›› Issue (04): 272-276.

• 专题综述 • 上一篇    下一篇

炎症与脑出血的靶向治疗

刘晓静,张拥波,李继梅   

  1. 100050 北京
    首都医科大学附属北京
    友谊医院神经内科
  • 收稿日期:2012-12-06 出版日期:2013-04-20 发布日期:2013-04-20
  • 通讯作者: 李继梅 jimeili2002@yahoo.com. cn

Inflammation as Therapeutic Target of Intracerebral Hemorrhage

  1. Department of Neurology, Beijing Friendship Hospital, Capital
    Medical University, Beijing 100050, China
  • Received:2012-12-06 Online:2013-04-20 Published:2013-04-20

摘要:

【摘要】 炎症在脑出血后继发性脑损伤过程中起关键作用,涉及胶质细胞、血管内皮细胞以及基 质金属蛋白酶(matrix metalloproteinases,MMP)、肿瘤坏死因子(tumor necrosis factor,TNF)-α、白 介素(interleukin,IL)及补体等多种炎症细胞及因子。目前对脑出血仍缺乏有效的治疗药物。针对脑出 血后炎症反应的治疗方法主要包括环氧化酶(cyclooxygenase,COX)抑制剂、MMP抑制剂、血管紧张素1 (angiotensin1,AT1)受体阻滞剂、他汀类药物、干细胞移植等,可能为脑出血的治疗提供新的靶点。

文章导读: 本文概述了脑出血后与炎症反应相关的可能的脑保护治疗靶点。

关键词: 脑出血; 损伤机制; 炎症细胞; 炎性因子; 治疗

Abstract:

【Abstract】 The mechanisms of brain damage induced by cerebral hemorrhage are complicated. Inflammation plays an important role in the secondary process of brain damage. It involves a lot of inflammatory cells and mediators. There are few treatments of cerebral hemorrhage. We conclude the potential drugs which target the inflammatory process during cerebral hemorrhage.

Key words: Cerebral hemorrhage; Damage mechanism; Inflammatory cells; Inflammatory
mediators;
Treatment