中国卒中杂志 ›› 2017, Vol. 12 ›› Issue (11): 1061-1066.DOI: 10.3969/j.issn.1673-5765.2017.11.016

• 综述 • 上一篇    下一篇

蛛网膜下腔出血后神经炎症反应的研究进展

王永朋,张彤宇,张广,徐善才,郑秉杰,史怀璋   

  1. 150001 哈尔滨哈尔滨医科大学附属第一医院神经外科三病房
  • 收稿日期:2016-12-15 出版日期:2017-11-20 发布日期:2017-11-20
  • 通讯作者: 史怀璋 huaizhangshi@163.com
  • 基金资助:

    国家青年科学基金项目(81100854)

Research Advance in Neurogenic Inflammation Induced by Subarachnoid Hemorrhage

  • Received:2016-12-15 Online:2017-11-20 Published:2017-11-20

摘要:

动脉瘤性蛛网膜下腔出血(aneurysmal subarachnoid hemorrhage,aSAH)是一种常见的脑血 管疾病。临床手术技术的提高虽然能够治疗动脉瘤,降低因再次出血而导致患者死亡的概率。但是, 目前尚无有效的针对蛛网膜下腔出血并发症的治疗方法。神经系统的炎症反应在蛛网膜下腔出血 后的病理过程中起着重要的作用,现研究已表明炎症反应与脑血管痉挛以及脑组织损伤相关。因此, 大量的临床前研究也针对神经炎症与aSAH之间的相关性展开,并发现炎症介质在其中发挥着重要的 作用。本文就已知的aSAH后神经炎症反应及其发生机制作一综述。

文章导读: 本文总结了蛛网膜下腔出血后神经系统炎症反应的发生机制及影响因素,阐述了炎症反应在蛛网膜下腔出血后脑损害过程中的重要作用,为研究以抑制炎症反应为靶点治疗蛛网膜下腔出血的并发症、改善患者的生存质量提出一个思路。

关键词: 动脉瘤性蛛网膜下腔出血; 脑血管痉挛; 神经炎症反应; 迟发性脑缺血

Abstract:

Aneurysmal subarachnoid hemorrhage (aSAH) was a common cerebrovascular disease. With the improvement of clinical surgical technology, the aneurysms can be treated and the mortality caused by rehaemorrhagia decreased, while there were few effective therapeutic measures in allusion to subarachnoid hemorrhage. It was known that neuroinflammation response played a critical role in pathological process after subarachnoid hemorrhage. Studies had shown that inflammation was associated with vasospasm and brain injury. Many preclinical studies had been conducted to explore the correlation between neuroinflammation and aSAH, and the researchers found that inflammatory mediator played an important role in this process. This article provided an overview of the neuroinflammation after aSAH and its pathogenic mechanism.

Key words: Aneurysmal subarachnoid hemorrhage; Cerebral vasospasm; Neuroinflammation response; Delayed cerebral ischemia