非高血压脑出血病因学研究进展

doi:10.3969/j.issn.1673-5765.2019.01.011

摘要/Abstract

摘要：

在非高血压性ICH病因中，脑血管结构病变如脑AVMs、海绵状血管瘤、rete MCA等可能通过病变局部血管结构及血流动力学的变化导致患者ICH风险增加；抗凝药和溶栓药物的应用可能通过改变患者血液凝结状态导致ICH；目前还发现抗抑郁药物等其他药物也有潜在导致患者ICH发生的风险，其机制尚不明确。研究还发现，一些全身性因素如血糖异常、肝功能异常，甚至儿童时期的生长暴露也可能影响患者的ICH风险。

文章导读： 本文对脑血管结构病变、脑淀粉样血管病、药物、全身性疾病和其他危险因素等导致ICH的病因学研究进展进行了综述，并在病因学分类的基础上介绍了相关生物学标志物，为非高血压ICH的临床诊疗提供一定的参考。

关键词: 脑出血; 病因学; 生物学标志物

Abstract:

Non-hypertensive intracerebral hemorrhage has various causes. Cerebrovascular structural abnormality such as arteriovenous malformation, cavernous hemangioma, aneurysm and venous dysplasia may increase the risk of cerebral hemorrhage by changing the local vascular structure and hemodynamics; the use of anticoagulants and thrombolytic drugs may lead to intracerebral hemorrhage by disturbing the normal blood clotting state of patients; the other drugs such as antidepressants may bring about a potential risk of intracerebral hemorrhage, while the underlying mechanism remains unclear; in addition, many studies have showed some systemic factors may be involved in intracerebral hemorrhage, such as abnormal blood sugar, liver dysfunction, and even growth exposure in childhood. This article reviewed that the advance in the etiology of non-hypertensive intracerebral hemorrhage.

Key words: Intracerebral hemorrhage; Etiology; Biomarker

王茜茜，张雨蕾，吴云成. 非高血压脑出血病因学研究进展[J]. 中国卒中杂志, 2019, 14(01): 58-62.

WANG Xi-Xi, ZHANG Yu-Lei, WU Yun-Cheng. Advance in Etiology of Non-hypertensive Cerebral Hemorrhage[J]. Chinese Journal of Stroke, 2019, 14(01): 58-62.

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