轻度认知功能障碍的神经影像学最新研究进展

doi:10.3969/j.issn.1673-5765.2019.03.022

摘要/Abstract

摘要：

轻度认知功能障碍（mild cognitive impairment，MCI）是介于正常老化、痴呆之间的一种临床状态，表现为轻度的记忆和智能损害，达不到痴呆诊断标准，但有进展为痴呆的高风险。因此，早发现、早诊断、早治疗非常关键。在MCI的具体诊断上，神经影像诊断表现出显著的临床应用价值，该诊断方式在早期诊断MCI及预防AD疾病的发生上具有显著作用。本文综述了当前国内外应用神经影像学诊断MCI的方法与结果，为进一步诊断及治疗MCI提供依据。

文章导读： 随着神经影像学技术的进展，可以通过不同MRI序列早期识别轻度认知功能障碍并对其转归进行判断。

关键词: 轻度认知功能障碍; 神经影像学; 阿尔茨海默病

Abstract:

Mild cognitive impairment (MCI) is an transition state between the cognitive changes of normal aging and clinical dementia, which is characterized by mild impairment of memory and intelligence. The general cognitive function and social ability in MCI patients remain intact and MCI doesn't meet the diagnostic criteria of dementia, while it has a high risk of developing dementia. Therefore, early detection, early diagnosis and early treatment are crucial for MCI. In the specific diagnosis of mild cognitive dysfunction, neuroimaging diagnosis has an important clinical diagnostic value, which plays a critical role in the early diagnosis of MCI and prevention of Alzheimer's disease. This article reviewed the methods and application of neuroimaging in the diagnosis of MCI, to provide a reference for clinical diagnosis and treatment of MCI.

Key words: Mild cognitive impairment; Neuroimaging; Alzheimer's disease

胡瑞红，范存秀，毕晓莹. 轻度认知功能障碍的神经影像学最新研究进展[J]. 中国卒中杂志, 2019, 14(03): 297-300.

HU Rui-Hong, FAN Cun-Xiu, BI Xiao-Ying. Progress in Neuroimaging of Mild Cognitive Impairment[J]. Chinese Journal of Stroke, 2019, 14(03): 297-300.

参考文献

[1] 谢冰，许顺江. 轻度认知障碍和阿尔茨海默病血、尿

β2-MG及尿mALB水平观察[J]. 中国神经精神疾病

杂志，2015（1）：54-56.

[2] MORRIS J C，STORANDT M，MILLER J P，et a1.

Mild cognitive impairment represents early stage

Alzheimer disease[J]. Alzheimers Dis，2005，7（3）：

235-239.

[3] JACOBS H I，GMNENSCHILD E H，EVERS E A，

et a1. Visuospatial processing in early Alzheimer's

disease：a multimodal neuroimaging study[J]. Conex，

2015（64）：394-406.

[4] PETERSEN R C. Mild cognitive impairment：

current research and clinical implications[J]. Semin

Neurol，2007，27（1）：22-31.

[5] MAYO C D，GARCIA-BARRERA M A，

MAZEROLLE E L，et al. Relationship Between

DTI Metrics and Cognitive Function in Alzheimer's

Disease[J/OL]. Front Aging Neurosci，2019，10：436.

doi：10.1016/j.neuroimage.2012.09.058.https：//doi.

org/10.3389/fnagi.2018.00436.

[6] ESKILDSEN S F，COUPE P，GARCIA-LORENZO

D，et al. Prediction of Alzheimer’s disease in

subjects with mild cognitive impairment from

the ADNI cohort using patterns of cortical

thinning[J/OL]. Neuroimage，2013，65：511-

521. https：//linkinghub.elsevier.com/retrieve/pii/

S1053811912009755.

[7] MASOODI N. Review：cholinesterase inhibitors

do not reduce progression to dementia from mild

cognitive impairment[J/OL]. Ann Intern Med，2013，

158（4）：JC3. https：//doi.org/10.7326/0003-4819-

158-4-201302190-02003.

[8] ERTEN-LYONS D，HOWIESON D，MOORE M M，

et al. Brain volume loss in MCI predicts dementia[J].

Neurology，2006，66（2）：233-235.

[9] BINNEWIJZEND M A，KUIJER J P，

BENEDICTUS M R，et a1. Cerebral blood flow

measured with 3D Dseudocontinuous arterial spinla-

beling MR imaging in Alzheimer disease and

mild cognitive im-pairment：a marker for disease

severity[J]. Radiology，2013，267（1）：221-230.

[10] DICKERSON B C，SALAT D H，BATES J F，et a1.

Medialtemporallobe function and structure in mild

cognitive impairment[J]. AnnNeurol，2004，56（1）：

27-35.

[11] BINNEWIJZEND M A，SCHOONHEIM M

M，SANZ-ARIGITA E，et al. Resting-state fMRI

changes in Alzheimer’s disease and mild cognitive

impairment[J]. eurobiol Aging，2012，3（9）：2018-

2028.

[12] CHA J，HWANG J M，JO H J，et al. Assessment of

functional characteristics of amnestic mild cognitive

impairment andAlzheimer’s disease using various

methods of resting-state fMRI analysis[J/OL].

Biomed Res Int，2015，2015：907464. https：//doi.

org/10.1155/2015/907464.

[13] YETKIN F Z，ROSENBERG R N，WEINER M

R，et a1. FMRI of working memory in patients with

mild cognitive impairment and probable Alzheimer's

disease[J]. Eur Radiol，2006，16（1）：193-206.

[14] SALI D，VERGANELAKIS D A，GOTSIS E，et al.

Diffusion tensor imaging（DTI）in the detection of

white matter lesions in patients with mild cognitive

impairment（MCI）[J]. Acta Neurol Belg，2013，

113（4）：441-451.

[15] LIU J，YIN C，XIA S，et al. White matter changes

in patients with amnestic mild cognitive impairment

detected by diffusion tensor imaging[J/OL]. PLoS

One，2013，8（3）：e59440. doi：10.1371/journal.

pone.0059440. https：//journals.plos.org/plosone/

article?id=10.1371/journal.pone.0059440.

[16] KANTARCI K，PETERSEN R C，BOEVE B F，et

a1. DWI predicts future progression to Alzheimer

disease in amnestic mild cognitive impairment[J].

Neurology，2005，64（5）：902-904.

[17] CHEN N C，HUANG C W，LUI C C，et a1.

Diffusion-weighted imaging improves prediction

in cognitive outcome and clinical phases in

patients with carbon monoxide intoxication[J].

Neuroradiology，2013，55（1）：107-115.

[18] ZHAO Y，WU G，SHI H，et a1. Relationship

between cognitive impairment and apparent difusion

coeficient values from magnetic resonance-diffusion

weighted imasing in elderly hypertensivepatients[J/

OL]. Clin Interv Aging，2014，9：1223-231. https：//

doi.org/10.2147/CIA.S63567.