总胆固醇/高密度脂蛋白胆固醇比值与缺血性卒中复发关系研究

doi:10.3969/j.issn.1673-5765.2019.08.006

摘要/Abstract

摘要：

目的探讨急性缺血性卒中90 d内复发与TC/HDL-C比值的关系。方法利用急性缺血性卒中患者氧化应激水平临床观察研究（Study on Oxidative Stress in Patients with Acute Ischemic Stroke，SOS-Stroke）数据库的3605例患者作为研究对象，采用多因素Logistic回归分析急性缺血性卒中患者90 d卒中复发的影响因素。结果该研究人群中有231例（6.40%）患者90 d卒中复发，多因素Logistics回归结果显示：年龄（OR 1.02，95%CI 1.00～1.03，P =0.011）、糖尿病史（OR 1.44，95%CI 1.00～2.07，P =0.048）是卒中复发的危险因素，住院期间服用降脂药物（OR 0.60，95%CI 0.40～0.90，P =0.012）则是卒中复发的保护因素，急性缺血性卒中患者中TC/HDL-C比值不是卒中复发的预测因素。结论 TC/HDL-C比值不能预测急性缺血性卒中90 d内复发的风险。

文章导读： 本研究对大样本、多中心临床研究数据库中急性缺血性卒中患者的数据进行多因素分析，结果显示高龄、糖尿病史是缺血性卒中复发的危险因素，住院期间服用降脂药物是缺血性卒中复发的保护因素，而在目前临床数据中，TC/HDL-C比值未显示出与缺血性卒中复发有关。

关键词: 急性缺血性卒中; 卒中复发; 胆固醇; 高密度脂蛋白胆固醇

Abstract:

Objective To investigate the correlation between TC/HDL-C ratio and recurrent stroke within 90 days after onset in patients with acute ischemic stroke (AIS). Methods The data of 3605 patients from the Study on Oxidative Stress in Patients with Acute Ischemic Stroke (SOS-Stroke) were selected. Multivariate logistic regression analysis was used to analyze the influence factors for recurrent stroke within 90 days after onset in patients with AIS. Results Recurrent stroke within 90 days occurred in 231 patients (6.40%). Logistic regression analysis showed that age (OR 1.02, 95%CI 1.00-1.03, P =0.011), history of diabetes (OR 1.44, 95%CI 1.00-2.07, P =0.048) were the risk factors of recurrent stroke, and taking lipid-lowering drugs during hospitalization (OR 0.60, 95%CI 0.40-0.90, P =0.012) was the protection factor of recurrent stroke. Conclusions TC/HDL-C ratio can’t predict the risk of recurrent stroke within 90 days after onset in AIS patients.

Key words: Ischemic stroke; Recurrent stroke; Total cholesterol; High density lipoprotein cholesterol

王林玉，韩坤强，管生，李振东. 总胆固醇/高密度脂蛋白胆固醇比值与缺血性卒中复发关系研究[J]. 中国卒中杂志, 2019, 14(08): 765-769.

WANG Lin-Yu, HAN Kun-Qiang, GUAN Sheng, LI Zhen-Dong. Correlation between Total Cholesterol / High Density Lipoprotein Cholesterol Ratio and Recurrent Stroke in Patients with Acute Ischemic Stroke[J]. Chinese Journal of Stroke, 2019, 14(08): 765-769.

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