中国卒中杂志 ›› 2020, Vol. 15 ›› Issue (01): 40-44.DOI: 10.3969/j.issn.1673-5765.2020.01.006

• 论著 • 上一篇    下一篇

老年轻型急性缺血性卒中后认知障碍与血清β2微球蛋白的关系研究

李施新,王莹,马清科,赵世娇,门慧,闫羽,陈宝鑫,刘雪梅,张志辰,朱晓晨,贺立娟,周晶,程苗苗,曹芯华,金香兰   

  1. 1100029 北京中医药大学第二临床医学院
    2北京中医药大学东方医院脑病科
  • 收稿日期:2019-08-13 出版日期:2020-01-20 发布日期:2020-01-20
  • 通讯作者: 金香兰 jxlan2001@126.com
  • 基金资助:

    2014年国家中医药管理局中医药行业科研专项(201407001-8)
    2015年国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015292)
    2018年国家重点研发计划(2018YFC1704303)

Correlation between Cognitive Impairment and Serum β2 Microglobulin Level in Eldly Patients with Acute Minor Ischemic Stroke

  • Received:2019-08-13 Online:2020-01-20 Published:2020-01-20

摘要:

目的 探讨血清β2微球蛋白水平与老年轻型急性缺血性卒中后认知障碍的关系,为预防老年轻型 卒中后认知障碍提供依据。 方法 回顾性分析2015年1月-2018年9月在北京中医药大学东方医院脑病科住院的老年轻型急性 缺血性卒中患者的临床资料,所有入组病例均在入院第2天采集空腹肘静脉血测定血清β2微球蛋白、 LDL-C、HDL-C等生化指标;发病第10~14天使用北京版MoCA量表进行评测,分为认知障碍组(MoCA评 分<26分)和无认知障碍组(MoCA评分≥26分),通过统计学分析,探讨老年轻型急性缺血性卒中后 认知障碍与血清β2微球蛋白之间的关系。 结果 研究共纳入106例老年轻型急性缺血性卒中患者,其中认知障碍组66例,无认知障碍 组40例。认知障碍组患者血清β2微球蛋白水平(P =0.040)、年龄(P =0.004)、高血压患者比例 (P =0.027)均高于无认知障碍组。多因素Logistic回归分析结果显示血清β2微球蛋白水平(OR 2.645, 95%CI 1.145~6.110,P =0.023)、年龄(OR 1.112,95%CI 1.041~1.188,P =0.002)、高血压(OR 2.806, 95%CI 1.057~7.452,P =0.038)是老年轻型急性缺血性卒中后认知障碍的危险因素。 结论 血清β2微球蛋白升高是老年轻型急性缺血性卒中后认知障碍的危险因素之一,血清β2微球 蛋白水平较高的老年轻型急性缺血性卒中患者应给予重视。

文章导读: 本研究发现年龄、高血压、血清β2微球蛋白是老年轻型急性缺血性卒中患者出现认知障碍的独立危险因素,血清β2微球蛋白水平较高的老年轻型急性缺血性卒中患者应给与重视。

关键词: 老年; 轻型卒中; 急性缺血性卒中; 认知障碍; 血清β 2微球蛋白

Abstract:

Objective To investigate the relationship between cognitive impairment and serum β2 microglobulin level in eldly patients with acute minor ischemic stroke. Methods Clinical data of elderly patients with acute minor ischemic stroke who were admitted to the Department of Encephalopathy, Dongfang Hospital of Beijing University of Chinese Medicine from January 2015 to September 2018 were retrospective analyzed. Serum β2 microglobulin was measured on the next day after admisson. On the 10th-14th day (the condition is stable and delirium is excluded), all patients were assessed using the Beijing version of MoCA and divided into cognitive impairment group (MoCA <26 points) and non-cognitive impairment group (MoCA ≥26 points). The relationship between cognitive impairment and serum β2 microglobulin in eldly patients with acute minor ischemic stroke was analyzed. Results A total of 106 elderly patients with acute minor ischemic stroke were included in this study, with 66 patients in cognitive impairment group and 40 patients in non-cognitive impairment group. Serum β2 microglobulin levels (P =0.040), age (P =0.004) and the percentage of hypertension (P =0.027)in the cognitive impairment group were all higher than that in non-cognitive impairment group. Multivariate logistic regression analysis showed that serum β2 microglobulin level (OR 2.645, 95%CI 1.145-6.110, P =0.023), age (OR 1.112, 95%CI 1.041-1.188, P =0.002) and hypertension (OR 2.806, 95%CI 1.057-7.452, P =0.038) was independent risk factors for cognitive impairment in eldly patients with acute minor ischemic stroke. Conclusions Serum β2 microglobulin is one of the risk factors for cognitive impairment in eldly patients with acute minor ischemic stroke.

Key words: Eldly; Minor stroke; Cognitive impairment; Serum β2 microglobulin