中国卒中杂志 ›› 2020, Vol. 15 ›› Issue (01): 108-114.DOI: 10.3969/j.issn.1673-5765.2020.01.018
• 综述 • 上一篇
邱晓雪,李世文,于鹭,武一平,林杰
收稿日期:
2018-11-23
出版日期:
2020-01-20
发布日期:
2020-01-20
通讯作者:
林杰 15631006079@163.com
Received:
2018-11-23
Online:
2020-01-20
Published:
2020-01-20
摘要:
炎症反应是缺血性卒中后病理生理的核心内容,其过程涉及免疫和炎症细胞,不同途径 和来源的被激活的炎症因子共同参与。早期小胶质细胞、中性粒细胞被激活,随之淋巴细胞的聚集 和浸润也增加了对脑细胞的损伤;但也有研究发现,在特定刺激下,中性粒细胞可以从促炎表型向 抗炎表型转变,进而保护脑细胞;淋巴细胞中部分T细胞亚型可以抑制促炎因子的表达、调节淋巴细 胞的活性,从而起到脑保护作用。另外,在缺血性卒中后,除脑内局部的炎症反应外,外周循环的炎 性反应和免疫抑制也参与其病理机制。免疫调节有望成为未来缺血性卒中治疗的靶点。
邱晓雪,李世文,于鹭,武一平,林杰. 炎症反应与缺血性卒中[J]. 中国卒中杂志, 2020, 15(01): 108-114.
QIU Xiao-Xue, LI Shi-Wen, Yu Lu, Wu Yi-Ping, Lin Jie. Inflammatory Response and Ischemic Stroke[J]. Chinese Journal of Stroke, 2020, 15(01): 108-114.
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