Correlation between Serum Alkaline Phosphatase and Recurrent Stroke in Patients with Mild Cerebral Infarction

doi:10.3969/j.issn.1673-5765.2020.06.013

Abstract

Abstract:

Objective To investigate the correlation between serum alkaline phosphatase (ALP) and recurrent stroke in patients with mild cerebral infarction. Methods Patients with mild cerebral infarction who were admitted to four tertiary-grade A class hospitals from Xi'an stroke database between January 2015 and December 2015 were included in this analysis. Based on the quartile of serum ALP levels detected within 24 hours after admission, all the patients were divided into four groups. The endpoints were recurrent stroke (including ischemic stroke, intracranial hemorrhage, and subarachnoid hemorrhage) within 1 year. Multivariate logistic regression analysis and curve fitting were used to evaluate the correlation between serum ALP level and 1-year stroke recurrence in patients with mild cerebral infarction. Results A total of 895 patients were included, with an average age of 63.52±12.31 years and 572 males (63.9%). The median NIHSS score at admission was 2 points, and recurrent stroke occurred in 26 patients (2.9%) during 1 year. Multivariate logistic regression analysis showed that the 1-year risk of stroke recurrence in patients with mild cerebral infarction increased by 2% per 1 U/L increase in serum ALP (OR 1.02, 95%CI 1.01-1.04, P =0.030), and the 1-year risk of stroke recurrence increased by 19% per 10 U/L increase (OR 1.19, 95%CI 1.01-1.41, P =0.030). There were no statistical difference in the 1-year stroke recurrence risk between the high level group (Q2, Q3 and Q4 groups) and the lowest level group (Q1 group), and as well as in the increase trend of stroke recurrence risk among the four groups. Conclusions Serum ALP may be an influencing factor for 1-year stroke recurrence in patients with mild cerebral infarction.

Key words: Serum alkaline phosphatase; Mild cerebral infarction; Stroke recurrence

摘要：

目的探讨血清碱性磷酸酶（alkaline phosphatase，ALP）水平与轻型脑梗死患者卒中复发相关性。方法通过西安脑卒中数据库，纳入西安市4所三级甲等医院2015年1-12月确诊的轻型脑梗死患者。入院24 h内检测血清ALP水平，并按照四分位数分组法分为四组。研究的终点事件为患者1年内卒中复发（包括脑梗死、脑出血、蛛网膜下腔出血）。采用多因素Logistic回归分析和曲线拟合评估血清ALP 水平与轻型脑梗死患者1年卒中复发的相关性。结果共纳入895例轻型脑梗死患者，平均年龄为63.52±12.31岁，男性572例（63.9%），入院NIHSS 评分中位数为2分，1年卒中复发为26例（2.9%）。多因素Logistic回归分析显示，血清ALP每升高1 U/L，轻型脑梗死患者的1年卒中复发风险增加2%（OR 1.02，95%CI 1.01～1.04，P =0.030）；每升高10 U/L， 1年卒中复发风险增加19%（OR 1.19，95%CI 1.01～1.41，P =0.030）。高水平组（Q2、Q3与Q4组）与最低水平组（Q1组）间的1年卒中复发风险差异均无统计学意义；四分组间1年卒中复发风险升高趋势无统计学意义。结论血清ALP可能是轻型脑梗死患者1年卒中复发的影响因素。

关键词: 血清碱性磷酸酶; 轻型脑梗死; 卒中复发

LU Qing-Li, LIU Zhong-Zhong, LIN Xue-Mei, CAO Huan, WANG Jing, LIU Pei, WANG Fang, SHI Ya-Ling, WANG Qing, LIU Guo-Zheng, WU Song-Di. Correlation between Serum Alkaline Phosphatase and Recurrent Stroke in Patients with Mild Cerebral Infarction[J]. Chinese Journal of Stroke, 2020, 15(06): 644-649.

逯青丽，刘仲仲，蔺雪梅，曹欢，王静，刘佩，王芳，史亚玲，王清，刘国正，吴松笛. 血清碱性磷酸酶水平与轻型脑梗死患者卒中复发相关性研究[J]. 中国卒中杂志, 2020, 15(06): 644-649.

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