Objective To explore the clinic significance and the correlation between the serum homocystein
(Hcy) and blood coagulation index in cerebral hemorrhage.
Methods A total of 146 patients with cerebral hemorrhage receiving treatment in the hospital from
2010 to 2014 were selected as the study subjects and contemporaneous 158 healthy individuals
of physical examination were taken as the control group. The patients in two groups were divided
into the youth group, middle age group, elderly age group and the longevity group by age. The
Hcy anomaly detection rate of cerebral hemorrhage group were analyzed, and the linear correlation
analysis between homocysteine and age was also made. The values of serum Hcy, D-Dimer,
prothrombin time (PT), prothrombin time activity (PTA), international standardization ratio (INR),
activated partial prothrombin time (APTT), fibrinogen (Fbg) level of above mentioned subgroups
were compared and performed with logistic regression analysis.
Results ①104 cases of cerebral hemorrhage group had increased Hcy with the abnormal rate
of 71.2% while male patients increased more obviously with the abnormal rate 83.3%. Compared
with the control group, there was a significant statistical difference. ②The serum Hcy, Fbg levels in
hemorrhage group were higher than those in the control group, and the difference was statistically
significant. PTA value level increased in middle age group and elderly age group, which had
significant difference with the control group. D-Dimer levels in the longevity group were obviously
higher than those in the control group. ③Logistic regression analysis showed that Hcy, D-Dimer, Fbg were independent risk factors for cerebral hemorrhage.
Conclusion Hcy is a risk factor for cerebral hemorrhage. Therefore, in the strategy of prevention
and treatment for cerebral hemorrhage, more importance should be attached to the intervention of
homocysteine levels.
