卒中：回眸2021

doi:10.3969/j.issn.1673-5765.2022.01.00110.3969/j.issn.1673-5765.2022.01.001

摘要/Abstract

关键词: 卒中; 机械取栓; 静脉溶栓; 移动卒中单元; 二级预防; 无症状颈内动脉狭窄; 隐源性卒中; 卵圆孔未闭; 心房颤动; 抗血小板治疗; 迷走神经刺激

王拥军, 熊云云, 李子孝, 张玉梅, 杨晓萌, 王上, 霍晓川, 杨明, 谢雪微, 罗岗, 陈晓霖, 李光硕, 王利圆, 王传颖, 闫然, 王文洁, 段春苗, 路正钊. 卒中：回眸2021[J]. 中国卒中杂志, 2022, 17(01): 1-20.

WANG Yongjun, XIONG Yunyun, LI Zixiao, ZHANG Yumei, YANG Xiaomeng, WANG Shang, HUO Xiaochuan, YANG Ming, XIE Xuewei, LUO Gang, CHEN Xiaolin, LI Guangshuo, WANG Liyuan, WANG Chuanying, YAN Ran, WANG Wenjie, DUAN Chunmiao, LU Zhengzhao. Highlights on Stroke Research in 2021[J]. Chinese Journal of Stroke, 2022, 17(01): 1-20.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://www.chinastroke.org.cn/CN/10.3969/j.issn.1673-5765.2022.01.00110.3969/j.issn.1673-5765.2022.01.001

https://www.chinastroke.org.cn/CN/Y2022/V17/I01/1

参考文献

[1] BARNETT H J M，TAYLOR D W，HAYNES R B，et al. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis[J]. N Engl J Med，1991，325（7）：445-453.
[2] H A N K EY G J. Evolut ion of evidence -based medicine in stroke[J]. Cerebrovasc Dis，2021，50（6）：644-655.
[3] LANGHORNE P，WILLIAMS B O，GILCHRIST W，et al. Do stroke units save lives?[J]. Lancet，1993，342（8868）：395-398.
[4] CLOTS（clots in legs or stockings after stroke）Trials Collaboration. Effect of intermittent pneumatic compression on disability，living circumstances，quality of life，and hospital costs after stroke：secondary analyses from CLOTS 3，a randomised trial[J]. Lancet Neurol，2014，13（12）：1186-1192.
[5] National Instit ute of Neu rological Disorders and Stroke r t-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke[J]. N Engl J Med，1995，333（24）：1581-1587.
[6] CAST（Chinese acute stroke trial）Collaborative Group. CAST：randomised placebo-controlled trial of early aspirin use in 20，000 patients with acute ischaemic stroke[J]. Lancet，1997，349（9066）：1641-1649.
[7] International Stroke Trial Collaborative Group. The international stroke trial（IST）：a randomised trial of aspirin，subcutaneous heparin，both，or neither among 19435 patients with acute ischaemic stroke[J]. Lancet，1997，349（9065）：1569-1581.
[8] WANG Y J，WANG Y L，ZHAO X Q，et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack[J]. N Engl J Med，2013，369（1）：11-19.
[9] SAVER J L，GOYAL M，BONAFE A，et al. Stentretriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke[J]. N Engl J Med，2015，372（24）：2285-2295.
[10] BERKHEMER O A，FRANSEN P S，BEUMER D，et al. A randomized trial of intraarterial treatment for acute ischemic stroke[J]. N Engl J Med，2015，372（1）：11-20.
[11] CAMPBELL B C，MITCHELL P J，KLEINIG T J，et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection[J]. N Engl J Med，2015，372（11）：1009-1018.
[12] GOYAL M，DEMCHUK A M，MENON B K，et al. Randomized assessment of rapid endovascular treatment of ischemic stroke[J]. N Engl J Med，2015，372（11）：1019-1030.

[13] JOVIN T G，CHAMORRO A，COBO E，et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke[J]. N Engl J Med，2015，372（24）：2296-2306.
[14] ALBERS G W，MARKS M P，KEMP S，et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging[J]. N Engl J Med，2018，378（8）：708-718.
[15] NOGUEIRA R G，JADHAV A P，HAUSSEN D C， et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct[J]. N Engl J Med，2018，378（1）：11-21.
[16] MA H，CAMPBELL B C V，PARSONS M W，et al. Thrombolysis guided by perfusion imaging up to 9 hours after onset of stroke[J]. N Engl J Med，2019，380（19）：1795-1803.
[17] JOHNSTON S C，AMARENCO P，DENISON H，et al. Ticagrelor and aspirin or aspirin alone in acute ischemic stroke or TIA[J]. N Engl J Med，2020，383（3）：207-217.
[18] GROTTA J C，YAMAL J M，PARKER S A，et al. Prospective，multicenter，controlled trial of mobile stroke units[J]. N Engl J Med，2021，385（11）：971-981.
[19] BERNSTEIN R A，KAMEL H，GRANGER C B，et al. Effect of Long-term continuous cardiac monitoring vs usual care on detection of atrial fibrillation in patients with stroke attributed to large- or small-vessel disease：the STROKE-AF randomized clinical trial[J]. JAMA，2021，325（21）：2169-2177.
[20] LEES K R，BLUHMKI E，VON KUMMER R，et al. Time to treatment with intravenous alteplase and outcome in stroke：an updated pooled analysis of ECASS，ATLANTIS，NINDS，and EPITHET trials[J]. Lancet，2010，375（9727）：1695-1703.
[21] SAVER J L，GOYAL M，VAN DER LUGT A，et al. Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke：a metaanalysis[J]. JAMA，2016，316（12）：1279-1288.
[22] FAS SBEN DER K，WALTER S，LIU Y，et al . " Mobile stroke unit " for hyperacute stroke treatment[J/OL]. Stroke，2003，34（6）： e44[2021-12-13]. https：//doi.org /10.1161/01.str.0000075573.22885.3b.
[23] KIM J，EASTON D，ZHAO H，et al. Economic evaluation of the melbourne mobile stroke unit[J]. Int J Stroke，2021，16（4）：466-475.
[24] EBINGER M，SIEGERINK B，KUNZ A，et al. Association between dispatch of mobile stroke units and functional outcomes among patients with acute ischemic stroke in Berlin[J]. JAMA，2021，325（5）：454-466.
[25] POWERS W J，RABINSTEIN A A，ACKERSON T，et al. Guidelines for the early management of patients with acute ischemic stroke：2019 update to the 2018 guidelines for the early management of acute ischemic stroke：a guideline for healthcare professionals from the American Heart Association/American Stroke Association[J/OL]. Stroke，2019，50（12）：e344 - e418[2021-12-13]. ht t ps：//doi.org/10.1161/str.0000000000000211.
[26] JOVIN T G，NOGUEIRA R G，LANSBERG M G，et al. Thrombectomy for anterior circulation stroke beyond 6 h from time last known well（AURORA）：a systematic review and individual patient data metaanalysis[J]. Lancet，2022，399(10321)：249-258.
[27] ALBERS G W，LANSBERG M G，BROWN S，et al. Assessment of optimal patient selection for endovascular thrombectomy beyond 6 hours after symptom onset：a pooled analysis of the AURORA database[J]. JAMA neurology，2021，78（9）：1064-1071.
[28] LIU X F，DAI Q L，YE R D，et al. Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion（BEST）：an openlabel，randomised controlled trial[J]. Lancet Neurol，2020，19（2）：115-122.
[29] LANGEZAAL L C M，VAN DER HOEVEN E，MONT'ALVERNE F J A，et al. Endovascular therapy for stroke due to basilar-artery occlusion[J]. N Engl J Med，2021，384（20）：1910-1920.
[30] 王拥军，熊云云，杨佳蕾，等. 卒中：回眸2020[J]. 中国卒中杂志，2021，16（2）：101-118.
[31] YANG P F，ZHANG Y W，ZHANG L，et al. Endovascular th rombectomy with or without intravenous alteplase in acute stroke[J]. N Engl J Med，2020，382（21）：1981-1993.
[32] ZI W Z，QIU Z M，LI F L，et al. Effect of endovascular t reat ment alone vs int ravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke：the DEVT randomized clinical trial[J]. JAMA，2021，325（3）：234-243.
[33] SUZUKI K，MATSUMARU Y，TAKEUCHI M，et al. Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke：the SKIP randomized clinical trial[J]. JAMA，2021，325（3）： 244-253.
[34] LECOUFFE N E，KAPPELHOF M，TREURNIET K M，et al. A randomized trial of intravenous alteplase before endovascular treatment for stroke[J]. N Engl J Med，2021，385（20）：1833-1844.
[35] CICCONE A. Alteplase and thrombectomy - not a bridge to dismantle[J]. N Engl J Med，2021，385（20）：1904-1905.
[36] PODLASEK A，DHILLON P S，BUTT W，et al. Direct mechanical th rombectomy without intravenous thrombolysis versus bridging therapy for acute ischemic stroke：a meta-analysis of randomized controlled trials[J]. Int J Stroke，2021，16（6）：621-631.
[37] MOCCO J，ZAIDAT O O，VON KUMMER R，et al. Aspiration thrombectomy after intravenous alteplase versus intravenous alteplase alone[J]. Stroke，2016，47（9）：2331-2338.
[38] LAPERGUE B，BLANC R，GORY B，et al. Effect of endovascular contact aspiration vs stent retriever on revascularization in patients with acute ischemic stroke and large vessel occlusion：the ASTER randomized clinical trial[J]. JAMA，2017，318（5）：443-452.
[39] TURK A S，SIDDIQUI A，FIFI J T，et al . Aspiration thrombectomy versus stent retrieer
thrombectomy as first-line approach for large vessel occlusion（COMPASS）：a multicentre，randomised，open label，blinded outcome，non-inferiority trial[J]. Lancet，2019，393（10175）：998-1008.
[40] LAPERGUE B，BLANC R，COSTALAT V，et al. Effect of thrombectomy with combined contact aspiration and stent retriever vs stent retriever alone on revascularization in patients with acute ischemic stroke and large vessel occlusion：the ASTER2 randomized clinical trial[J]. JAMA，2021，326（12）：1158-1169.
[41] MÜLLER M D，LYRER P，BROWN M M，et al. Carotid artery stenting versus endarterectomy for treatment of carotid artery stenosis[J/OL]. Cochrane Database Syst Rev，2020，2（2）：CD000515[2021-12-13]. https：//doi.org/10.1002/14651858.cd000515.pub5.
[42] CHAMBERS B R，DONNAN G A . Carotid endarterectomy for asymptomatic carotid stenosis[J/OL]. Coch rane Database Syst Rev，2005（4）：CD001923[2021-12-13]. https：//doi.org/10.1002/14651858.cd001923.pub2.
[43] HALLIDAY A，BULBULIA R，BONATI L H，et al. Second asymptomatic carotid surgery trial（ACST-2）： a randomised comparison of carotid artery stenting versus carotid endarterectomy[J]. Lancet，2021，398（10305）：1065-1073.
[44] GLADSTONE D J，SPRING M，DORIAN P，et al. Atrial fibrillation in patients with cryptogenic stroke[J]. N Engl J Med，2014，370（26）：2467-2477.
[45] SANNA T，DIENER H C，PASSMAN R S，et al. Cry ptogenic stroke and underlying atrial fibrillation[J]. N Engl J Med，2014，370（26）：2478-2486.
[46] HEALEY J S，CONNOLLY S J，GOLD M R，et al. Subclinical atrial fibrillation and the risk of stroke[J]. N Engl J Med，2012，366（2）：120-129.
[47] BUCK B H，HILL M D，QUINN F R，et al.
Effect of implant able vs prolonged external electrocardiographic monitoring on atrial fibrillation detection in patients with ischemic stroke：the PERDIEM randomized clinical Trial[J]. JAMA，2021，325（21）：2160-2168.
[48] NINNO T D. The STROKE-AF and PER DIEM trials：detection of atrial fibrillation after stroke[EB/OL]. （2021-07-26）[2021-12-28]. https：//rebelem.com/the-stroke-af-and-per-diem-trials-detection-ofatrial-fibrillation-after-stroke/.
[49] HAEUSLER K G，KIRCHHOF P，KUNZE C，et al. Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke（MonDAFIS）：a randomised，open-label，multicentre study[J]. Lancet Neurol，2021，20（6）：426-436.
[50] KASNER S E，RHODES J F，ANDERSEN G，et al. Five-year outcomes of PFO closure or antiplatelet therapy for cryptogenic stroke[J]. N Engl J Med，2021，384（10）：970-971.
[51] KENT D M，SAVER J L，KASNER S E，et al. Heterogeneity of treatment effects in an analysis of pooled individual patient data from randomized trials of device closure of patent foramen ovale after stroke[J]. JAMA，2021，326（22）：2277-2286.
[52] WHITLOCK R P，BELLEY-COTE E P，PAPARELLA D，et al. Left atrial appendage occlusion during cardiac surgery to prevent stroke[J]. N Engl J Med，2021，384（22）：2081-2091.
[53] NIELSEN-KUDSK J E，KORSHOLM K，
DAMGAARD D，et al. Clinical outcomes associated with left atrial appendage occlusion versus direct oral anticoagulation in atrial fibrillation[J]. JACC Cardiovasc Interv，2021，14（1）：69-78.
[54] KENNEDY J，HILL M D，RYCKBORST K J，et al. Fast assessment of stroke and transient ischaemic attack to prevent early recurrence（FASTER）：a randomised controlled pilot trial[J]. Lancet Neurol，2007，6（11）：961-969.
[55] JOHNSTON S C，EASTON J D，FARRANT M，et al. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA[J]. N Engl J Med，2018，379（3）：215-225.
[56] WANG Y L，CHEN W Q，LIN Y，et al. Ticagrelor plus aspirin versus clopidogrel plus aspirin for platelet reactivity in patients with minor stroke or transient ischaemic attack：open label，blinded endpoint，randomised controlled phase Ⅱ trial[J/OL]. BMJ，2019，365：l2211[2021-12-13]. https：//doi.org/10.1136/bmj.l2211.
[57] LUN R，DHALIWAL S，ZITIKYTE G，et al.
Comparison of ticagrelor vs clopidogrel in addition to aspirin in patients with minor ischemic stroke and transient ischemic attack：a network meta-analysis[J/OL]. JAMA neurology，2021，e214514[2021-12-13]. https：//doi.org/10.1001/jamaneurol.2021.4514.
[58] FONSECA A C，MERWICK Á，DENNIS M，et al. European Stroke Organisation（ESO）guidelines on management of transient ischaemic attack[J/OL]. Eur Stroke J，2021，6（2）：CLⅩⅢ-CLⅩⅩⅩⅥ[2021-12-13]. https：//doi.org/10.1177/2396987321992905.
[59] K L E I N D OR F E R D O，TOW F IGH I A ，CHATURVEDI S，et al. 2021 Guideline for the prevention of stroke in patients with stroke and transient ischemic attack：a guideline from
the American Heart Association /American Stroke Association[J/OL]. Stroke，2021，52（7）：e364-e467[2021-12-13]. https：//doi.org/10.1161/str.0000000000000375.
[60] GLADSTONE D J，LINDSAY M P，DOUKETIS J，et al. Canadian stroke best practice recommendations：secondary prevention of stroke update 2020[J/OL].
Can J Neurol Sci，2021：1-23[2021-12-13]. https：//doi.org/10.1017/cjn.2021.127.
[61] WANG Y L，ZHAO X Q，LIN J X，et al. Association between CYP2C19 loss-of-function allele status and efficacy of clopidogrel for risk reduction among patients with minor stroke or transient ischemic attack[J]. JAMA，2016，316（1）：70-78.
[62] WANG Y J，MENG X，WANG A X，et al. Ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA[J]. N Engl J Med，2021.385（27）：2520-2530.
[63] MEYERS E C，SOLORZANO B R，JAMES J，et al. Vagus nerve stimulation enhances stable plasticity and generalization of stroke recovery[J]. Stroke，2018，49（3）：710-717.
[64] DAWSON J，PIERCE D，DIXIT A，et al. Safety，feasibility，and efficacy of vagus nerve stimulation paired with upper-limb rehabilitation after ischemic stroke[J]. Stroke，2016，47（1）：143-150.
[65] KIMBERLEY T J，PIERCE D，PRUDENTE C N，et al. Vagus nerve stimulation paired with upper limb rehabilitation after chronic stroke[J]. Stroke，2018，49（11）：2789-2792.
[66] DAWSON J，LIU C Y，FRANCISCO G E，et al. Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke（VNS-REHAB）：a randomised，blinded，pivotal，device trial[J]. Lancet，2021，397（10284）：1545-1553.
[67] VAN DER MEIJ A，WERMER M J H. Vagus nerve stimulation：a potential new treatment for ischaemic stroke[J]. Lancet，2021，397（10284）：1520-1521.