Challenges and Breakthroughs in Basic and Clinical Research of Brain Cytoprotective Agents for Acute Ischemic Stroke in China

doi:10.3969/j.issn.1673-5765.2026.05.001

Abstract

Abstract: Brain cytoprotection therapy serves as an important adjunct to reperfusion therapy for acute ischemic stroke, yet it has long faced challenges in clinical translation. In recent years, research teams in China, guided by clinical needs, have made notable progress in this field. This article systematically reviews the progress of basic and clinical research on brain cytoprotection. Firstly, it elaborates on the core therapeutic targets, and the guiding role of the stroke treatment academic industry roundtable (STAIR) and the stroke preclinical assessment network (SPAN). Secondly, it highlights the breakthrough achievements in clinical research in China, including the research data and clinical application value of representative drugs such as edaravone dexborneol, minocycline, and loberamisal. Finally, it analyzes the current challenges faced in this field and looks forward to future development strategies, aiming to provide a reference for promoting the innovation and clinical translation of brain cytoprotection therapy for acute ischemic stroke.

Key words: Acute ischemic stroke; Brain cytoprotective agent; Stroke treatment academic industry roundtable; Edaravone dexborneol; Minocycline; Loberamisal

摘要： 脑细胞保护治疗是急性缺血性卒中再灌注治疗的重要补充手段，但长期面临临床转化困境。近年来，我国科研团队立足临床需要，在相关研究领域取得了一定进展。本文系统梳理了脑细胞保护的基础实验与临床研究进展。首先，阐述了脑细胞保护核心治疗靶点、卒中治疗学术产业圆桌会议（stroke treatment academic industry roundtable，STAIR）与卒中临床前评估网络（stroke preclinical assessment network，SPAN）的规范指导作用；其次，重点总结了我国在临床研究中取得的突破性成果，包括依达拉奉右莰醇、米诺环素、洛贝米柳等代表性药物的研究数据与临床应用价值；最后，分析了当前该领域面临的挑战，并展望未来发展策略，以期为推动急性缺血性卒中脑细胞保护治疗的创新与临床转化提供参考。

关键词: 急性缺血性卒中; 脑细胞保护剂; 卒中治疗学术产业圆桌会议; 依达拉奉右莰醇; 米诺环素; 洛贝米柳

CLC Number:

HE Dandan, LI Jian, WANG Chunjuan, LI Shuya. Challenges and Breakthroughs in Basic and Clinical Research of Brain Cytoprotective Agents for Acute Ischemic Stroke in China[J]. Chinese Journal of Stroke, 2026, 21(5): 517-524.

何丹丹, 李俭, 王春娟, 李姝雅. 我国急性缺血性卒中脑细胞保护剂基础实验与临床研究的挑战与突破[J]. 中国卒中杂志, 2026, 21(5): 517-524.

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URL: https://www.chinastroke.org.cn/EN/10.3969/j.issn.1673-5765.2026.05.001

https://www.chinastroke.org.cn/EN/Y2026/V21/I5/517

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