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    20 April 2026, Volume 21 Issue 4
    From Surveillance to Intervention: Reflections on the Public Health Practice Pathway for Stroke Prevention and Control
    HUANG Wei, CHU Xiaoting, WAN Qiuping, YU Huiting, YANG Xiaoming
    2026, 21(4):  387-397.  DOI: 10.3969/j.issn.1673-5765.2026.04.001
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    Stroke is a major public health challenge in China, and its prevention and control requires close coordination among three key links: surveillance, evaluation, and intervention. While considerable progress has been made in China’s stroke prevention and control in the construction of surveillance networks and indicator systems, the development of stroke centers and emergency networks, and the implementation of high-risk population screening and medical quality control, persistent gaps in the linkage among these components still limit the efficiency of the current prevention and control pathway. From a public health practice perspective, this paper reviews the status and achievements of the three components. The surveillance system has been initially established with an expanding range of surveillance indicators, yet it faces challenges such as information silos, uneven coverage, and variable data quality. Evaluation has progressed from descriptive analysis to process assessment, but still requires improvement in systematic framework, locally validated tools, and translation into decision-making. Intervention has seen continuous enhancement of acute care systems, yet multi-sectoral collaboration, closed-loop management of high-risk populations, and post-acute care continuity need further strengthening. To address these issues, this paper proposes a whole-chain optimization strategy that includes institutional coordination to break down sectoral barriers, resource reallocation to bridge urban-rural gaps, technological empowerment to improve precision, and payment reform to drive service integration. These measures aim to shift stroke prevention and control from “technical correctness” to “practical effectiveness”, providing a reference for refining China’s public health pathway for stroke control.
    Epidemiological Investigation on the Disease Burden of Cerebrovascular Diseases
    YU Huiting, YANG Xiaoming
    2026, 21(4):  398-398. 
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    Trend Analysis and Prediction of Stroke Disease Burden in Jing’an District, Shanghai, 2005-2024
    WAN Qiuping, WANG Yunhui, JIN Shuying, CHU Xiaoting, YANG Xiaoming
    2026, 21(4):  399-410.  DOI: 10.3969/j.issn.1673-5765.2026.04.002
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    Objective  To analyze the trends of stroke mortality and disability-adjusted life year (DALY) rates among residents in Jing’an District, Shanghai from 2005 to 2024, and predict the stroke disease burden in this region from 2025 to 2030, so as to provide evidence for developing targeted stroke prevention and control strategies. 
    Methods  Data were derived from the death surveillance records of residents in Jing’an District, which were included in the death registration information system of the Shanghai Municipal Center for Disease Control and Prevention. Death cases with stroke as the underlying cause of death from January 1, 2005 to December 31, 2024 were extracted. The crude mortality was calculated, and the crude DALY rate was indirectly estimated based on the global burden of disease (GBD) 2021 data. The age-standardized mortality and DALY rates were calculated using the world standard population age composition released by GBD 2021, hereinafter referred to as the world age-standardized mortality rate and world age-standardized DALY rate. The Joinpoint regression model was used to analyze the annual percent change (APC), average annual percent change (AAPC), temporal trends, and trend turning points of crude mortality rate, crude DALY rate, and their world age‑standardized rates. The Bayesian age-period-cohort (BAPC) model was employed to predict the world age-standardized mortality and DALY rates in Jing’an District, Shanghai from 2025 to 2030. 
    Results  From 2005 to 2024, a total of 35 817 stroke-related deaths were reported in Jing’an District, Shanghai, accounting for 19.90% of all deaths in the district during the same period, among which ischemic stroke deaths accounted for 74.91%. The proportion of comorbidities, including hypertension, coronary heart disease, and diabetes mellitus, among stroke deaths showed a fluctuating upward trend. Joinpoint regression analysis revealed that the world age-standardized mortality (AAPC -2.23%, 95%CI -2.95%--1.51%, P<0.001) and world age-standardized DALY rate (AAPC -2.35%, 95%CI -3.10%--1.60%, P<0.001) for stroke in the overall population of Jing’an District, Shanghai from 2005 to 2024 both showed downward trends. Since 2016, the declining trends in the world age-standardized mortality and world age-standardized DALY rates for stroke in males have stagnated, yet the changes were not statistically significant. Age-stratified analysis revealed that residents aged 85 years and above had relatively high stroke mortality. Moreover, the declining trend in stroke mortality among those aged 65-74 reversed to an upward trend after 2017. The BAPC model predicted that the world age-standardized mortality and DALY rates for stroke in Jing’an District, Shanghai would continue to decline from 2025 to 2030.
    Conclusions  Overall decreasing trends in the world age-standardized mortality and DALY rates for stroke were observed in Jing’an District, Shanghai from 2005 to 2024, reflecting favorable outcomes of regional stroke prevention and control. However, the declining trend in stroke disease burden among males has stagnated since 2016. With deepening population aging and growing chronic comorbidity burden, future stroke prevention and control should prioritize males and the elderly, and shift the management paradigm from single-disease intervention to integrated multimorbidity management.
    Trends in Cerebrovascular Disease Mortality and Its Impact on Life Expectancy in Shanghai from 2002 to 2021
    CAI Renzhi, SHAO Haiyan, CHEN Lei, QIAN Naisi, LI Qi, JIN Shan, YANG Zhiyu, YU Huiting
    2026, 21(4):  411-421.  DOI: 10.3969/j.issn.1673-5765.2026.04.003
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    Objective  To analyze the trends in cerebrovascular disease mortality and the impact on life expectancy in Shanghai from 2002 to 2021, and to provide evidence for the formulation of precision prevention and control strategies for cerebrovascular disease. 
    Methods  Mortality data of cerebrovascular disease among registered residents in Shanghai from 2002 to 2021 were collected from the death registration information system of the Shanghai Municipal Center for Disease Control and Prevention. Joinpoint regression models were used to examine the trends in cerebrovascular disease mortality in the overall population and by sex, age group, region, and disease subtype. Arriaga’s life table decomposition method was employed to quantify the contributions of mortality declines from acute cerebrovascular disease and cerebrovascular disease sequelae to life expectancy gains by age group and sex.
    Results  From 2002 to 2021, the crude mortality rate of cerebrovascular disease in Shanghai increased from 142.51/100 000 to 181.90/100 000 [average annual percent change (AAPC) 1.17%, P<0.001], while the standardized mortality rate decreased from 101.28/100 000 to 68.00/100 000 (AAPC -2.08%, P<0.001), with a slowdown in decline after 2010 [annual percent change (APC) changed from -2.88% to -1.50%]. The crude mortality rate of acute cerebrovascular disease in urban districts shifted from decreasing to increasing after 2013 (APC changed from -0.71% to 1.55%), whereas that in suburban districts showed a trend of continuous decline followed by a plateau, with an overall AAPC of -2.06% (P<0.001). The standardized mortality rates of acute cerebrovascular disease continued to decline in both urban and suburban areas, with AAPCs of –3.28% (P<0.001) and –5.39% (P<0.001), respectively. The crude mortality rates of cerebrovascular disease sequelae showed a continuous increase in both urban and suburban areas, with AAPCs of 3.34% (P<0.001) and 6.66% (P<0.001), respectively. The standardized mortality rate of cerebrovascular disease sequelae continued to rise in suburban areas (AAPC 3.08%, P<0.001), but shifted from a non-significant trend to a decreasing trend after 2012 in urban areas (APC –2.51%, P<0.001). Age‑specific crude mortality rates of acute cerebrovascular disease all showed a decreasing trend (all AAPC<0, P<0.001), whereas the trends for crude mortality rates of cerebrovascular disease sequelae varied across age groups. Different subtypes of cerebrovascular disease exhibited different mortality trends; notably, the crude mortality rate of ischemic stroke sequelae (AAPC 7.05%, P<0.001) and its standardized mortality rate (AAPC 3.49%, P<0.05) both increased. The decline in cerebrovascular disease mortality contributed 0.8814 years to the increase in life expectancy, with acute cerebrovascular disease contributing 0.9951 years and sequelae contributing –0.1137 years. The 75-84 years age group made the largest contribution (0.4696 years). The gain in total life expectancy attributed to the decline in acute cerebrovascular disease mortality was higher in males (1.0473 years) than in females (0.9571 years).
    Conclusions  The standardized mortality rate of cerebrovascular disease in Shanghai declined continuously from 2002 to 2021 but slowed after 2010. Current major challenges include urban-suburban disparities, the continuously increasing mortality from cerebrovascular disease sequelae among young and middle-aged populations, the plateaued trend in the oldest-old group, and the rising mortality rate of ischemic stroke sequelae. Future prevention and control strategies should focus on strengthening the management of disease sequelae and building a life-course precision prevention and control system.
    Effects of Pain, Anxiety, and Usual Activities on Self-Rated Health Status among Individuals at High Risk of Cardiovascular and Cerebrovascular Diseases
    HUANG Wei, YANG Xiaoming, XIANG Yunjie, SHEN Yi, ZHANG Xin, CHEN Jiehua, CHEN Chuanying, CHU Xiaoting, FANG Jialie
    2026, 21(4):  422-429.  DOI: 10.3969/j.issn.1673-5765.2026.04.004
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    Objective  To explore the relative contributions and pathways of pain, anxiety, and usual activities in the EuroQol five dimensions questionnaire (EQ-5D) to self-rated health among individuals at high risk of cardiovascular and cerebrovascular diseases.
    Methods  A cross-sectional design was used. A multistage stratified random sampling survey was conducted in Jing’an District, Shanghai, from January to March 2025. A total of 2410 community adults were enrolled, and individuals at high risk of cardiovascular and cerebrovascular diseases were identified. Data were collected including sociodemographic characteristics, behavioral factors, physical examination indicators, chronic disease status, as well as scores for pain, anxiety, and usual activities in the EQ-5D and the results of the EuroQol visual analogue scale (EQ-VAS). Multivariate linear regression analysis was used to examine the associations between EQ-5D dimension scores and EQ-VAS score. Relative weight analysis was applied to quantify the relative contribution of each EQ-5D dimension score to the coefficient of determination of the model. The Bootstrap method was used to verify whether anxiety could exert an indirect effect on self-rated health via pain and usual activities.
    Results  A total of 212 high-risk individuals were included, of whom 189 (89%) were male. Multivariate linear regression analysis showed that pain (β=-3.615, 95%CI -6.138--1.093, P=0.005), anxiety (β=-5.743, 95%CI -10.294--1.192, P=0.014), and usual activities (β=-2.902, 95%CI -5.752--0.051, P=0.046) were significantly negatively associated with EQ-VAS score. Relative weight analysis indicated that the three EQ-5D dimensions collectively explained 16.17% of the coefficient of determination in the model. Pain made the largest relative contribution (6.40%, 95%CI 1.92%-12.77%), followed by anxiety (6.01%, 95%CI 1.35%-12.81%), and usual activities yielded the smallest relative contribution (3.76%, 95%CI 1.04%-7.90%). Mediation analysis revealed that anxiety had indirect effects on self-rated health through pain (indirect effect=-3.15, 95%CI -5.55--1.23) and usual activities (indirect effect=-2.32, 95%CI -5.38--0.31).
    Conclusions  Pain, anxiety, and usual activities are important influencing factors of self-rated health among individuals at high risk of cardiovascular and cerebrovascular diseases. Anxiety may reduce self-rated health by exacerbating pain and impairing usual activities. Comprehensive management of pain and anxiety should be emphasized in health interventions for these individuals.
    Association between Physical Activity and Self-Rated Health Status in Populations with Different Cardiovascular and Cerebrovascular Disease Risk Levels
    CHU Xiaoting, YANG Xiaoming, XIANG Yunjie, SHEN Yi, ZHANG Xin, CHEN Jiehua, CHEN Chuanying, HUANG Wei, FANG Jialie
    2026, 21(4):  430-438.  DOI: 10.3969/j.issn.1673-5765.2026.04.005
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    Objective  To investigate the association between physical activity and self-rated health in populations with different cardiovascular and cerebrovascular disease risk levels, and to provide a scientific basis for precise health interventions.
    Methods  A cross-sectional study design was adopted. The 10-year risk of cardiovascular and cerebrovascular diseases was assessed using the prediction for atherosclerotic cardiovascular disease risk in China (China-PAR) model among participants aged 35-75 years in Jing’an District, Shanghai. They were divided into a low-to-moderate risk group (10-year cardiovascular and cerebrovascular disease risk<10%) and a high-risk group (10-year cardiovascular and cerebrovascular disease risk≥10%). Self-rated health status was evaluated using the EuroQol visual analogue scale (EQ-VAS). Data on physical activity (including leisure-time activity, household activity, transport activity, and total physical activity), sedentary time, screen time, and sleep time over the past seven days were collected using the long-form international physical activity questionnaire. Spearman rank correlation analysis was used to analyze the correlations between various physical activity indicators and the EQ-VAS score. Considering that total physical activity is a cumulative indicator of the three types of activities, and screen time can be regarded as an important component of sedentary time, four multivariate linear regression models (sedentary time+three types of activities, sedentary time+total physical activity, screen time+three types of activities, screen time+total physical activity) were constructed separately for the low-to-moderate risk and high-risk populations to explore the differential effects of individual activities versus cumulative activity, and the independent contributions of screen time versus total sedentary time. All models were adjusted for confounding factors such as gender, education level, alcohol consumption, chronic diseases, and BMI.
    Results  Using the China-PAR model, the 10-year risk of cardiovascular and cerebrovascular diseases was assessed among 2410 participants, identifying 2198 (91.20%) as low-to-moderate risk and 212 (8.80%) as high risk. There were 853 males (38.81%) in the low-to-moderate risk group and 189 males (89.15%) in the high-risk group, indicating a higher proportion of males in the high-risk group. Compared with the low-to-moderate risk group, the high-risk group exhibited lower EQ-VAS scores, older age, lower education levels, higher proportion of alcohol consumption, higher prevalence of chronic diseases, higher BMI, less household activity and total physical activity, and longer sleep time (all P<0.05), with no significant differences in other indicators. Spearman rank correlation analysis showed that transport activity was negatively correlated with EQ-VAS scores in the high-risk group (rs=-0.154, P=0.025). Multivariate linear regression analysis revealed that in the low-to-moderate risk group, chronic disease was negatively associated with EQ-VAS scores in the four models (β=-3.921 to -3.876, all P<0.001), while total physical activity was positively associated with EQ-VAS scores in Model 2 and Model 4 (β=0.377 to 0.381, all P<0.05). In the high-risk group, transport activity was negatively associated with EQ-VAS scores in Model 1 and Model 3 (β=-1.058 to -0.975, all P<0.05), while leisure-time activity in Model 1 and Model 3 (β=0.873 to 1.105, all P<0.05) and screen time in Model 3 and Model 4 (β=1.415 to 1.438, all P<0.05) were positively associated with EQ-VAS scores. Sleep duration was positively correlated with EQ-VAS scores only in Model 1 (β = 6.947, P = 0.038). Males were negatively associated with EQ-VAS scores in the four models (β=-6.242 to -5.517, all P<0.05).
    Conclusions  The association between physical activity and self-rated health exhibits significant heterogeneity across populations with different cardiovascular and cerebrovascular disease risk levels. In the low-to-moderate risk population, accumulation of total physical activity and chronic disease management play important roles in maintaining health. In the high-risk population, leisure-time activity and screen time are positively associated with self-rated health, while transport activity is negatively associated, and self-rated health is significantly poorer in males. The prevention and control of cardiovascular and cerebrovascular diseases should adopt differentiated intervention strategies based on population risk levels. For the high-risk population, attention should be paid to the complex effects of physical activity on self-rated health, and males should be prioritized as a key target group for interventions.
    Population Attributable Fraction Analysis of Sleep Quality and Smoking for Stroke in the Elderly
    CHEN Jiehua, CHU Xiaoting, YANG Xiaoming, ZHANG Xin, CHEN Chuanying, WAN Qiuping, ZHU Yichen, ZHOU Zhou
    2026, 21(4):  439-445.  DOI: 10.3969/j.issn.1673-5765.2026.04.006
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    Objective  To analyze the epidemiological characteristics of stroke among the elderly in Jing’an District, Shanghai, to explore the independent and interactive effects of sleep quality and smoking on stroke in the elderly, and to calculate the population attributable fraction (PAF), so as to provide a scientific basis for formulating primary prevention strategies for stroke in the elderly.
    Methods  A cross-sectional survey was conducted among 2380 permanent residents (residing continuously in Jing’an District for more than 6 months) aged≥60 years in Jing’an District, Shanghai, from April to July 2025 using a multistage stratified random sampling method. Information such as demographic characteristics, stroke prevalence, smoking status, and chronic disease history was collected. The sleep quality of the study participants was assessed using the Pittsburgh sleep quality index (PSQI). Multivariate logistic regression was used to analyze influencing factors of stroke in the elderly and to test the interaction between poor sleep quality (PSQI total score>7 points) and smoking. The PAF of poor sleep quality and smoking, as well as their combined PAF for stroke in the elderly, was calculated. Two sensitivity analyses were conducted to test the robustness of the results, including adjusting the cutoff for poor sleep quality (PSQI total score>5 points) and excluding patients with atrial fibrillation.
    Results  A total of 224 stroke patients were included, with a prevalence rate of 9.41%. There were 751 participants (31.55%) with poor sleep quality and 587 smokers (24.66%). After adjusting for confounding factors including age and hypertension history, multivariate logistic regression showed that poor sleep quality (OR 2.782, 95%CI 2.082-3.717, P<0.001) and smoking (OR 1.538, 95%CI 1.116-2.120, P=0.009) were independent risk factors for stroke in the elderly, with no significant interaction between the two factors (Pfor interaction=0.791). PAF analysis showed that the PAF of poor sleep quality was 35.99%, the PAF of smoking was 11.71%, and the combined PAF was 43.49%. Sensitivity analyses confirmed robust associations between poor sleep quality and stroke (OR 2.29-3.01), with a combined PAF of 44.02%-45.57%, further confirming the robustness of the results.
    Conclusions  The prevalence of stroke is relatively high among the elderly in Jing’an District, Shanghai. Poor sleep quality and smoking are important risk factors for stroke in this population. This provides a scientific basis for integrating sleep health management into the routine health management system for the elderly and promoting it jointly with tobacco control measures to reduce the stroke burden in this population.
    Association between Extreme Temperatures and Cerebrovascular Disease Deaths in Shanghai from 2014 to 2020
    LI Qi, JIN Shan, CHEN Lei, YANG Zhiyu, CAI Renzhi, QIAN Naisi, ZHENG Yaxu, YU Huiting
    2026, 21(4):  446-455.  DOI: 10.3969/j.issn.1673-5765.2026.04.007
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    Objective  To explore the association between extreme temperatures and cerebrovascular disease mortality among residents in Shanghai, and to investigate the lag effects of temperature on cerebrovascular disease deaths.
    Methods  Data for this study were obtained from the death registration information system of the Shanghai Municipal Center for Disease Control & Prevention. Daily mortality data on cerebrovascular disease (including three subtypes: hemorrhagic stroke, cerebral infarction, and sequelae of cerebrovascular disease) among residents in Shanghai from January 1, 2014 to December 31, 2020 were collected, with causes of death coded and determined based on the underlying cause of death. A distributed lag non-linear model was used to quantitatively estimate the association between exposure to extreme temperatures and the mortality risk of cerebrovascular disease within a lag period of 0 to 21 days. Extreme low temperature and extreme high temperature were defined as below the 2.5th percentile and above the 97.5th percentile of daily mean temperature during the study period, respectively. Stratified analyses were conducted by cerebrovascular disease subtype, gender, age, and education level to explore the heterogeneity of the association across different populations.
    Results  A total of 162 928 cerebrovascular disease deaths were included in this study. The exposure-response curves for the RR of death from overall cerebrovascular disease, cerebral infarction, and sequelae of cerebrovascular disease in relation to daily mean temperature exhibited an inverted J-shape, with the minimum mortality temperature ranging from 22.7 ℃ to 27.9 ℃. The mortality risk of cerebrovascular disease associated with extreme low temperature was higher among patients aged 0-64 years than those aged≥65 years [RR 2.35 (95%CI 1.50-3.68) vs. RR 1.86 (95%CI 1.60-2.16), P=0.01], and higher for patients with cerebral infarction and sequelae of cerebrovascular disease than for those with hemorrhagic stroke. The overall mortality risk of cerebrovascular disease associated with extreme high temperature peaked on the first day after exposure (RR 1.09, 95%CI 1.05-1.13) and persisted until the seventh day. The mortality risk for sequelae of cerebrovascular disease was the highest at a lag of seven days (RR 1.22, 95%CI 1.15-1.30).
    Conclusions  Exposure to extreme temperatures is significantly associated with an increased risk of cerebrovascular disease mortality in Shanghai, and the association shows heterogeneity across different populations and cerebrovascular disease subtypes.
    Analysis of Influencing Factors for Early Motor Function Recovery of Proximal and Distal Upper Limbs in Patients with Cerebral Infarction
    YE Shanshan, LIN Jiali, LIN Jiaying, QIAN Jiayu, JIA Jie
    2026, 21(4):  456-462.  DOI: 10.3969/j.issn.1673-5765.2026.04.008
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    Objective  To explore the factors influencing the poor early motor function recovery of proximal and distal upper limbs in patients with cerebral infarction.
    Methods   This study prospectively enrolled patients with acute cerebral infarction accompanied by upper limb dysfunction admitted to the Department of Neurology, the First Affiliated Hospital of Fujian Medical University from November 2023 to December 2024. The Fugl-Meyer motor assessment-upper extremity (FMA-UE) was used to conduct the first and second assessments at 3-7 days and 8-12 days after onset, respectively, with an interval of≥5 days. Relevant demographic and clinical data were collected. Patients were then divided into a poor proximal recovery group (estimated total recovery value of proximal FMA-UE score, ΔFJ<2.08) and a good proximal recovery group (ΔFJ≥2.08), as well as a poor distal recovery group (estimated total recovery value of distal FMA-UE score, ΔFY<1.67) and a good distal recovery group (ΔFY≥1.67) based on the recovery outcome of upper limb motor function. Univariate analysis and multivariate analysis (binary logistic regression analysis) were performed separately for proximal and distal upper limbs to explore the influencing factors of poor early motor function recovery.
    Results  A total of 81 patients with acute cerebral infarction accompanied by upper limb dysfunction were enrolled in this study, including 32 patients in the poor proximal recovery group and 49 in the good proximal recovery group, as well as 44 patients in the poor distal recovery group and 37 in the good distal recovery group. Multivariate analysis revealed that low red blood cell count (OR 0.271, 95%CI 0.083-0.877, P=0.029) and low first proximal FMA-UE assessment score (F1J) (OR 0.917, 95%CI 0.855-0.984, P=0.016) were independent risk factors for poor early motor function recovery of the proximal upper limb. Proprioceptive dysfunction (OR 8.077, 95%CI 1.325-49.250, P=0.024), low red blood cell count (OR 0.187, 95%CI 0.039-0.893, P=0.036), low F1J (OR 0.783, 95%CI 0.687-0.892, P<0.001), and low first distal FMA-UE assessment score (F1Y) (OR 0.638, 95%CI 0.469-0.868, P=0.004) were independent risk factors for poor early motor function recovery of the distal upper limb.
    Conclusions  Red blood cell count and F1J may be independent influencing factors for poor early motor function recovery of the proximal upper limb in patients with cerebral infarction, while proprioceptive dysfunction, red blood cell count, F1J, and F1Y may be independent influencing factors for poor early motor function recovery of the distal upper limb.
    Efficacy and Safety of Different Thrombectomy Devices in the Treatment of Acute Ischemic Stroke: A Retrospective Comparative Study
    LIU Yuanhao, WU Lei, YANG Huan, ZHU Jiaying, LI Yazhe
    2026, 21(4):  463-470.  DOI: 10.3969/j.issn.1673-5765.2026.04.009
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    Objective  To compare the efficacy and safety of the domestic Captor® thrombectomy device with the imported SolitaireTM thrombectomy device in mechanical thrombectomy for acute ischemic stroke (AIS).
    Methods  This was a single-center retrospective study that consecutively enrolled patients with AIS who underwent mechanical thrombectomy at the First Hospital of Qinhuangdao between March 2024 and November 2025. Patients were classified into the Captor® or SolitaireTM group according to the thrombectomy device used. The primary efficacy endpoints were the first-pass recanalization [modified thrombolysis in cerebral infarction (mTICI) grade 2b/3] and the final recanalization. Secondary efficacy endpoints included the number of thrombectomy passes, NIHSS scores at 24 hours post-procedure and at discharge, the degree of NIHSS improvement (admission score minus the discharge score), 90-day favorable prognosis (mRS score 0-2), and procedure time. Safety outcomes included 24-hour postoperative hemorrhagic events, perioperative vascular complications, 90-day all-cause mortality, and 90-day stroke recurrence.
    Results  A total of 181 patients with AIS were enrolled in this study, including 159 in the Captor® group and 22 in the SolitaireTM group. Baseline demographic characteristics and major clinical data were comparable between the two groups, except for the prevalence of hypertension, which was significantly lower in the Captor® group (P=0.047). No significant differences were observed in the first-pass recanalization rate [99.4% (157/158) vs. 100% (18/18), P=0.998] or the final successful recanalization rate [98.1% (156/159) vs. 95.5% (21/22), P=0.407]. The Captor® group required fewer thrombectomy passes than the SolitaireTM group [(1.03±0.24) times vs. (1.23±0.61) times, P=0.004]. There were no statistically significant differences between the two groups regarding the 24-hour postoperative NIHSS score [11.0 (6.5-16.0) vs. 11.0 (9.0-18.5), P=0.510], NIHSS score at discharge [6.0 (3.0-17.0) vs. 6.5 (4.0-15.2), P=0.930], the degree of NIHSS improvement [4.0 (-0.2-9.0) vs. 6.5 (0.5-15.0), P=0.213], 90-day favorable prognosis rate [30.6% (37/121) vs. 47.4% (9/19), P=0.129], or procedure time [90 (72-110) minutes vs. 105 (53-115) minutes, P=0.678]. The incidence of 24-hour postoperative hemorrhagic events was 0.8% (1/132) in the Captor® group and 0 (0/19) in the SolitaireTM group, with no significant difference between the two groups (P=0.349). No perioperative vascular complications occurred in either group (P=0.957). Likewise, 90-day all-cause mortality [26.4% (32/121) vs. 21.1% (4/19), P=0.277] was similar between the groups. No 90-day stroke recurrence events were observed in either group (P=0.277).
    Conclusions  The domestic Captor® thrombectomy device demonstrates favorable efficacy and safety that may be comparable to the SolitaireTM thrombectomy device in the treatment of AIS. Further prospective randomized clinical trials are needed to confirm these findings.
    Expert Consensus on the “Hospital-Community-Family” Three-Tier Process of Integrated Sports and Medicine for Weight Management
    Expert Consensus on the “Hospital-Community-Family” Three-Tier Process of Integrated Sports and Medicine for Weight Management Writing Group, Stroke High-Risk Population Management Branch of the Chinese Stroke Association, Sports and Health Branch of the Chinese Preventive Medicine Association, Beijing Municipal Bureau of Sports
    2026, 21(4):  471-483.  DOI: 10.3969/j.issn.1673-5765.2026.04.010
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    The burden of chronic diseases in China remains severe. As major risk factors for these diseases and key targets for primary prevention, overweight and obesity have yet to be effectively controlled. Current weight management in practice encounters significant challenges, including high exercise-related risks, poor sustainability, and high susceptibility to weight regain. In 2024, the National Health Commission launched a three-year “Weight Management Year” initiative, which identifies scientific exercise and nutritional intervention as core components of weight management and emphasizes that the integrated sports and medicine model is expected to shift the focus of chronic disease prevention and control to an earlier stage. However, the integration of sports and medicine for weight management still faces a clear disconnect: on the one hand, sports or exercise lacks scientific medical assessment, professional diagnosis, or safety assurance; on the other hand, clinical medicine tends to emphasize therapeutic interventions such as pharmacotherapy, devices, and surgery, leading to issues of affordability and accessibility. Consequently, the fields of sports and medicine have yet to achieve a systematic and effective integration. Although both have successively established guidelines for exercise and standards for exercise prescriptions in chronic diseases, current protocols remain at an exploratory stage. Their limited efficacy and specificity impede effective clinical translation. Therefore, a multidisciplinary expert group formed by the Stroke High-Risk Population Management Branch of the Chinese Stroke Association, Sports and Health Branch of the Chinese Preventive Medicine Association, and Beijing Municipal Bureau of Sports jointly developed the Expert Consensus on the “Hospital-Community-Family” Three-Tier Process of Integrated Sports and Medicine for Weight Management. This expert consensus, for the first time, proposes nine recommendations for a “hospital-community-family” three-tier process for weight management based on integrated sports and medicine, thereby providing a new paradigm for advancing innovative weight management strategies and reshaping the landscape of public health. Guided by the overarching principle of being “safe, effective, and sustainable”, the consensus emphasizes multi-sectoral and multidisciplinary collaboration. It establishes a digital and intelligent three-tier health management model integrating sports and medicine, underpinned by an active health service consortium within the medical alliance, hubed in communities, workplaces, schools, and clubs for the integration of sports and medicine and terminated at families and individuals. This framework aims to provide a replicable, scalable, and standardized protocol for weight management that addresses practical challenges in lifestyle interventions, thereby promoting the normalization and long-term sustainability of healthy lifestyles.
    Interpretation of the Group Standard: Nursing Standards of Venous Thromboembolism Preventive in Stroke Patients
    ZHANG Ran, SUN Weige, XING Yana, TIAN Ganlu, CAI Weixin
    2026, 21(4):  484-492.  DOI: 10.3969/j.issn.1673-5765.2026.04.011
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    In August 2024, the Chinese Research Hospital Association released the group standard Nursing Standards of Venous Thromboembolism Preventive in Stroke Patients (T/CRHA 077-2024). This standard specifies the fundamental requirements, assessment, early warning, preventive measures, health education, transitional care, and nursing management for the prevention and management of venous thromboembolism in stroke patients. This article interprets the key points of this standard to facilitate accurate understanding and effective application by nursing staff across various levels of healthcare institutions. The aim is to standardize the clinical nursing practice for venous thromboembolism prevention in stroke patients.
    A Case Report of Cerebral Venous Thrombosis Associated with a Heterozygous PAI-1 Gene  4G/5G Polymorphism
    WANG Shanzheng, GU Zhiying, CHEN Cuiyun, LI Sanming
    2026, 21(4):  493-501.  DOI: 10.3969/j.issn.1673-5765.2026.04.012
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    Cerebral venous thrombosis (CVT) is a distinct type of cerebrovascular disease with a complex pathogenesis. This paper reports a case of CVT initially presenting with symptoms of acute ischemic stroke. The patient received intravenous thrombolysis with urokinase within the therapeutic time window after admission. The symptoms subsequently recurred despite antiplatelet and other treatments and were accompanied by focal epileptic seizures. Cranial MRI+MRV+SWI revealed cerebral venous sinus thrombosis complicated by hemorrhagic cortical venous infarction.The patient had a family history of venous thrombosis. Laboratory investigations showed elevated plasma D-dimer, C-reactive protein levels, and erythrocyte sedimentation rate. Subsequent thrombophilia genetic testing indicated a heterozygous 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene associated with CVT. The patient showed marked symptomatic improvement after anticoagulant therapy, with good neurological recovery and no recurrence during follow-up at 1 week and 2 months.
    A Case Report of TIA Associated with Bihemispheric Anterior Cerebral Artery
    GU Jingyu, XU Chunli, WANG Yongpeng, QIN Yong, XU Wenjie, WANG Feng
    2026, 21(4):  502-507.  DOI: 10.3969/j.issn.1673-5765.2026.04.013
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    Bihemispheric anterior cerebral artery is a rare vascular variant that can affect cerebral blood flow distribution and increase the difficulty in diagnosing ischemic events. This article reports a case of TIA presenting with recurrent alternating unilateral lower limb weakness as the primary manifestation. Imaging examinations revealed hypoplasia of the right A1 segment of the anterior cerebral artery, severe stenosis of the left A2 segment, and the presence of a bihemispheric anterior cerebral artery variant; brain CTP indicated hypoperfusion in the bilateral anterior cerebral artery territories. After comprehensive evaluation, the patient received intravenous thrombolysis and intensive antiplatelet therapy, with no recurrence observed during follow-up. Multimodal imaging suggested that the clinical manifestations were closely related to hemodynamic abnormalities associated with hypoperfusion. This case suggests that in patients presenting with alternating unilateral lower limb weakness, vigilance is required regarding cerebrovascular variants and hypoperfusion mechanisms, and multimodal imaging examinations should be considered when necessary to improve diagnostic accuracy.
    Refractory Seizures During Sodium Valproate Therapy: A Case Report on Recognition of the Drug-Related Pitfall in MELAS
    TAN Qingjing, HUANG Meihua, LIU Yanfang, ZHOU Heng, CHEN Weiqi, WANG Yilong
    2026, 21(4):  508-516.  DOI: 10.3969/j.issn.1673-5765.2026.04.014
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    Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episode (MELAS) is a maternally inherited oxidative phosphorylation disorder caused by mitochondrial DNA mutations. In its early stage, MELAS often presents with seizures, headache, or stroke-like episodes, and is therefore prone to be misdiagnosed as seizure and inappropriate exposure to drugs with mitochondrial toxicity. This paper reports a 15-year-old male patient who initially presented with recurrent headache accompanied by convulsions. The patient had been treated at an external hospital with long-term oral sodium valproate for presumed migraine and epilepsy, but with poor clinical response. Subsequently, the patient developed symptoms of stroke-like episodes, including aphasia and hemianopia. Brain MRI revealed cortical migratory lesions extending beyond vascular territories, together with a characteristic “lace-like” sign. Combined with developmental retardation, elevated blood lactate, and the presence of the mitochondrial DNA m.3243A>G mutation, a definitive diagnosis of MELAS was established. Sodium valproate was discontinued, and mitochondrial-targeted supportive therapy centered on L-arginine was initiated, after which the patient showed short-term clinical improvement. Combined with literature review, this case highlights that MELAS and its potential drug-related pitfalls should be strongly suspected in adolescents with epilepsy who fail to respond to sodium valproate and show stroke-like imaging changes. Early genetic testing and timely adjustment of treatment strategies are essential.