中国卒中杂志 ›› 2024, Vol. 19 ›› Issue (6): 706-713.DOI: 10.3969/j.issn.1673-5765.2024.06.011

• 综述 • 上一篇    下一篇

牛磺酸在代谢性脑血管病中的潜在作用及其机制研究进展

温家琦1,2,庞江霞1,2,陈超1,2,姜长春1,2,郝喜娃1,2   

  1. 1 包头 014040 包头市中心医院神经内科
    2 内蒙古自治区神经系统疾病临床医学研究中心
  • 收稿日期:2023-10-13 出版日期:2024-06-20 发布日期:2024-06-20
  • 通讯作者: 郝喜娃 haoxiwa1985@sina.com

Research Progress on the Potential Role of Taurine in Cerebro-Metabolic Disease and its Mechanism

WEN Jiaqi1,2, PANG Jiangxia1,2, CHEN Chao1,2, JIANG Changchun1,2, HAO Xiwa1,2   

  1. 1 Department of Neurology, Baotou Central Hospital, Baotou 014040, China
    2 Inner Mongolia Autonomous Region Clinical Medical Research Center for Neurological Diseases, Baotou 014040, China
  • Received:2023-10-13 Online:2024-06-20 Published:2024-06-20
  • Contact: HAO Xiwa, E-mail: haoxiwa1985@sina.com

摘要: 代谢性脑血管病以代谢危险因素引起的脑血管损害为核心,其概念已被提出并处于早期探索阶段。代谢性脑血管病的防治重点在于控制代谢危险因素,目前临床用药策略仍是对各个代谢危险因素进行单独干预,因用药种类多和剂量大给患者带来很多困扰。因此,临床亟需一种具有多作用靶点、可协同作用的药物以减少代谢性脑血管病患者的用药负担并提高疗效。牛磺酸作为一种条件必需氨基酸,具有调节糖脂代谢、调节渗透压、稳定细胞膜、抗氧化、抗衰老等多种生物学作用,对代谢性脑血管病治疗具有潜在临床价值。本文聚焦牛磺酸多效性,探讨牛磺酸在代谢性脑血管病中的作用机制及其临床应用前景。

文章导读: 本文阐述了牛磺酸抗动脉粥样硬化、抗血栓形成、抗衰老和脑保护的多重作用机制,说明其具备“多效性”和“一专多能”特性,可能在治疗代谢性脑血管病方面具有广阔的临床应用价值。

关键词: 牛磺酸; 代谢性脑血管病; 多效性

Abstract: The concept of cerebro-metabolic disease, which centers on cerebrovascular damage caused by metabolic risk factors, has been proposed and is in the early stages of exploration. The prevention and treatment of cerebro-metabolic disease focus on the control of metabolic risk factors. At present, the clinical drug strategy is still based on the individual intervention of each metabolic risk factor, which brings a lot of trouble to patients due to the variety of drugs used and the high dosage. Therefore, there is an urgent need for a synergistic drug with multiple targets to reduce the drug burden and improve the efficacy in patients with cerebro-metabolic disease. Taurine, as a conditionally essential amino acid, has a variety of biological effects such as regulation of glycolipid metabolism, osmotic pressure regulation, cell membrane stabilization, antioxidation, anti-aging, etc., which has potential clinical value for cerebro-metabolic disease treatment. This paper focused on the pleiotropy of taurine and discussed the mechanism of taurine in cerebro-metabolic disease and its clinical application prospects.

Key words: Taurine; Cerebro-metabolic disease; Pleiotropy

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