关键词: 颅内动脉狭窄; 肥胖; 横断面研究

Abstract: Objective To explore the relationship between different obesity indexes(body mass index[BMI],waist circumference[WC], waist-to-height ratio[WHtR], waist-to-hip ratio[WHpR]) and intracranialarterial stenosis.Methods The cross-sectional method was used and 5440 subjects were selected from 101 510employees including retired ones aging over 40-years old who took part in health examinationfrom July to October 2006 based on Kailuan Group Company. The clinical data collected consist ofdemography information, clinical baseline data and transcranial doppler(TCD) data. The relationbetween different obesity indexes and intracranial arterial stenosis was obtained using univariateand multivariate logistic regression analysis.Results The average age of the subjects is 55.17±11.78 years. Among 5440 subjects, the number ofmale subjects is 3257(59.87%) and female is 2183(40.13%). Intracranial arterial stenosis is foundin 716 subjects and the incidence is 13.16%. The univariate and multivariate logistic regressionanalysis shows that different obesity indexes correlate with intracranial arterial stenosis to acertain degree. The comparison between the second, third, forth quartile and the first quartile ofWHpR are statistically significant(P <0.05). The adjusted odds ratio and 95% confidence intervalare 1.33(1.04-1.70), 1.34(1.05-1.73) and 1.38(1.08-1.76) respectively.Conclusion The prevalence of intracranial arterial stenosis is 13.16%; obesity is an important riskfactor for intracranial arterial stenosis, and WHpR is a better representative index compared withother obesity indexes.

Key words: Intracranial arterial stenosis; Obesity; Cross-sectional Survey