关键词: 神经调控技术; 呼吸功能重建; 重症卒中; “脑-肺交互”理论

Abstract: Respiratory dysfunction is an important factor for poor respiratory prognosis in patients with severe stroke. Conventional single rehabilitation methods cannot accurately address multiple pathological mechanisms after stroke, including dysregulated respiratory central drive, peripheral respiratory pump failure, and “brain-lung interaction” disorder. This article systematically reviews the research progress of neuromodulation technologies in respiratory function reconstruction for severe stroke patients. Based on the theoretical framework of “brain-lung interaction”, it elaborates on the mechanisms of action and relevant clinical evidence of central and peripheral neuromodulation technologies, while emphasizing their potential application value in restoring respiratory central drive and regulating respiratory rhythm synchrony. Although several challenges remain in this field, such as inadequate elaboration of mechanisms of action and lack of standardized intervention parameters, the integration of multimodal assessment and individualized regulation protocols is expected to promote the development of neuro-respiratory rehabilitation toward precision and closed-loop management in the future.

Key words: Neuromodulation technology; Respiratory function reconstruction; Severe stroke; “Brain-lung interaction” theory