Research Status of Radiological-Pathological Correlation and Mechanisms of Cerebral Microbleeds

Abstract

Abstract:

Cerebral microbleeds(CMBs) have been increasingly recognized with the development of advanced magnetic resonance imaging(MRI) techniques. Recent studies of microbleeds experienced explosive growth, becoming a hot spot of cerebrovascular disease and dementia research. However, the research about radiological-pathological correlation and the mechanisms of CMBs is not much. This review will summarize MRI criteria, radiological-pathological correlation, risk factors and the mechanisms of CMBs according to imaging and pathological studies, in order to provide an important basis for the further research of microbleeds-related ischemic stroke and hemorrhagic stroke.

Key words: Cerebral microbleeds; Mechanism; Pathology; Imaging; Blood-brain barrier

摘要：

随着磁共振成像（magnetic resonance imaging，MRI）新技术的发展，颅内微出血的检出率大幅提高，近来相关研究呈爆发式增长，成为脑血管病和痴呆领域的研究热点，然而涉及微出血影像学与病理表现关系及机制的研究并不多。本综述将从微出血影像学检查和病理研究这两个方面，总结文献中颅内微出血的影像学诊断、影像-病理联系、危险因素及发生机制，旨在为微出血相关的缺血性卒中和出血性卒中提供重要依据。

关键词: 颅内微出血; 机制; 病理学; 影像学; 血脑屏障

MAO Ying-Ying, YAN Shen-Qiang, LOU Min. Research Status of Radiological-Pathological Correlation and Mechanisms of Cerebral Microbleeds[J]. Chinese Journal of Stroke, 2015, 10(10): 872-877.

毛颖盈，严慎强，楼敏. 颅内微出血的影像——病理联系及机制研究现状[J]. 中国卒中杂志, 2015, 10(10): 872-877.

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