Abstract:

Objective To evaluate the curative effects and security of intra-arterial thrombolysis for mild acute ischemic stroke (NIHSS<5) in 6~9 hours time window. Methods Restrospective analysis was made based on the data of 86 mild acute ischemic stroke patients (NIHSS<5) who received treatment within 6~9 hours after onset. The therapeutic effects of intra-arterial thrombolysis by using urokinase and aspirin on 7th day and 90th day after onset were compared. Results Compared with prescribed aspirin, the BI (81.3±7.9 vs 54.5±9.3, P =0.034) of thrombolysis group increased significantly on the 7th day of hospitalization, while the mRS (88.4% vs 48.8%, P =0.028) decreased obviously. Neither mRS nor BI had significant difference between two groups after 90 days. Conclusion Intra-arterial thrombolysis is a safe and effective therapeutic method for mild acute ischemic stroke within 6~9 hours, which benefits early recovery.

Key words: Intra-arterial thrombolysis; Mild stroke; Time window; Quality of life

摘要：

目的 探讨发病6～9 h动脉溶栓治疗对美国国立卫生研究院卒中量表（National I nstitutes o f H ealth Stroke Scale，NIHSS）＜5分的急性缺血性卒中患者的治疗效果。 方法 回顾86例发病距接受治疗的时间6～9 h的急性缺血性卒中（NIHSS＜5分）患者资料，比较选择 性尿激酶动脉溶栓和口服阿司匹林2种治疗方法的发病7 d和90 d效果。 结果 与口服阿司匹林组相比，选择性动脉溶栓组患者发病7 d的Barthel指数(Barthel index，BI)较对 照组明显改善（81.3±7.9 vs 54.5±9.3，P =0.034），改良Rankin量表（modified Rankin Scale，mRS）评 分＜3分的患者比例明显增加（88.4% vs 48.8%，P =0.028）；但在90 d后，两组患者的BI及mRS之间没 有显著差异。 结论 对急性轻型缺血性卒中6～9 h积极的动脉尿激酶溶栓治疗可以促进患者的早期恢复。

关键词: 动脉溶栓; 轻型卒中; 时间窗; 生活质量