The Research of Endogenous Formaldehyde and Inflammatory Medium in the Pathogenesis of Vascular Dementia

doi:10.3969/j.issn.1673-5765.2016.11.006

Abstract

Abstract:

Objective To evaluate the correlation of inflammatory medium (interleukin-2, IL-2 and tumor necrosis factor-α, TNF-α) and vascular dementia (VaD), so as to provide the biochemical markers for clinical early diagnosis of VaD. Methods A total of 42 patients in outpatient and wards with VaD were taken as experimental group, and 54 cases in the community without cognitive impairment were taken as control group. The level of IL-2 and TNF-α in serum and the formaldehyde concentration (FA) in urine were detected. The FA/Cr was used as rectified concentration to compare the differences in above mentioned indexes between two groups. Results The concentration of urine formaldehyde is observably higher in VaD than in the control group (6.31±0.53 vs 4.40±0.31), which had statistical significance (P =0.007). Conclusion The concentration of urine formaldehyde in VaD patients was significantly increased. The increased formaldehyde concentration in the urine is expected to be one of the biomarkers in the diagnosis of VaD.

Key words: Vascular dementia; Endogenous formaldehyde; Interleukin-2; Tumor necrosis factor-α

摘要：

目的评价炎症介质白介素-2（interleukin-2，IL-2）、肿瘤坏死因子-α（tumor necrosis factor-α， TNF-α）及尿液内源性甲醛浓度（formaldehyde，FA）与血管性痴呆（vascular dementia，VaD）的关系，为临床VaD的早期诊断提供生化标志物诊断方法。方法选取北京老年医院精神心理门诊和病房VaD患者42例为试验组，选取社区内认知功能正常者54例为对照组，测定研究对象血浆中I L-2和TNF-α的水平，测定尿液内源性甲醛的含量，以尿液中甲醛浓度除以肌酐（creatinine，Cr）浓度值（FA/Cr）作为内源性甲醛校正浓度，比较两组上述指标的差异。结果与对照组相比，VaD患者尿液内源性甲醛浓度含量显著升高（6.31±0.53 vs 4.40±0.31， P =0.007）。结论 VaD患者尿液中内源性甲醛浓度升高，或可作为临床诊断VaD的生物标志物之一。

关键词: 血管性痴呆; 内源性甲醛; 白介素-2; 肿瘤坏死因子

WU Hai-Yan, MA Li, ZHANG Li, et al.. The Research of Endogenous Formaldehyde and Inflammatory Medium in the Pathogenesis of Vascular Dementia[J]. Chinese Journal of Stroke, 2016, 11(11): 930-933.

武海燕，马丽，张力，曹萌，张守字，苏涛，赫荣乔. 内源性甲醛及炎症介质在血管性痴呆中的研究[J]. 中国卒中杂志, 2016, 11(11): 930-933.

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