Progress of Influencing Factors for Intracranial and Extracranial Atherosclerotic Stenosis in High Altitude Region

doi:10.3969/j.issn.1673-5765.2021.02.018

Abstract

Abstract:

Intracranial and extracranial atherosclerotic stenosis is an important cause of ischemic stroke. In high-altitude ecological environment, low oxygen and low pressure lead to the adaptive changes in the body of the people in plateau, such as hemoglobin concentration increase, gut microbial ecological decline and sympathetic nervous excitement. These adaptive changes also bring blood viscosity increase, metabolic disorders and blood vessels damage, which play a key role in the process of the formation of atherosclerotic stenosis. In addition, high fat, less fruits and vegetables and other dietary habits of plateau population also further promote the occurrence and development of atherosclerosis.

Key words: High altitude; Hypoxia; Intra-and extra-cranial atherosclerotic stenosis; Risk factor

摘要：

高原地区缺血性卒中呈逐年上升趋势，颅内外动脉粥样硬化性狭窄是缺血性卒中的重要病因。高海拔地区低氧、低压的特殊生态环境，导致高原世居人群为了更好适应高原环境而发生血红蛋白水平升高、肠道微生物生态性下降、交感神经兴奋等适应性改变，但也带来了血液黏稠度增加、代谢障碍及血管受损的影响，在动脉粥样硬化性狭窄的形成过程中起到关键作用。此外，高原人群高脂、少蔬果等饮食习惯进一步促进了动脉粥样硬化的发生发展。

关键词: 高海拔; 低氧; 颅内外动脉粥样硬化性狭窄; 危险因素

LIU Zhu, FAN Qing-Li, WU Shi-Zheng. Progress of Influencing Factors for Intracranial and Extracranial Atherosclerotic Stenosis in High Altitude Region[J]. Chinese Journal of Stroke, 2021, 16(02): 208-212.

刘著，樊青俐，吴世政. 高海拔地区颅内外动脉粥样硬化性狭窄影响因素研究进展[J]. 中国卒中杂志, 2021, 16(02): 208-212.

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