Application Progress of Vascular Ultrasound in Cerebral Small Vessel Disease

doi:10.3969/j.issn.1673-5765.2024.03.014

Abstract

Abstract: Ultrasound has been gradually applied to the field of cerebral small vessel disease (CSVD) due to its unique advantages. This paper summarized the studies related to ultrasound in CSVD, and summarized the relationship between CSVD and various evaluation indicators of vascular ultrasound. What’s more, this paper described the role of ultrasound in the evaluation and diagnosis of multi-system diseases such as heart, brain, and kidney coexisting with CSVD, and provided a theoretical basis for comprehensive and effective evaluation of CSVD by ultrasound.

Key words: Cerebral small vessel disease; Carotid ultrasound; Transcranial Doppler

摘要： 超声由于其独特的优势已逐渐应用于脑小血管病领域。本文汇总了超声在脑小血管病中应用的相关研究，概述了脑小血管病与血管超声各类评估指标之间的关系，并描述了超声在与脑小血管病并存的心、脑、肾等多系统疾病中的评估、诊断作用，为应用超声对脑小血管病进行全面有效评估提供了理论依据。

关键词: 脑小血管病; 颈动脉超声; 经颅多普勒超声

CLC Number:

PAN Xijuan, XING Yingqi, LIU Yumei. Application Progress of Vascular Ultrasound in Cerebral Small Vessel Disease[J]. Chinese Journal of Stroke, 2024, 19(3): 343-348.

潘希娟, 邢英琦, 刘玉梅. 血管超声在脑小血管病中的应用进展[J]. 中国卒中杂志, 2024, 19(3): 343-348.

References

[1] PASI M，CORDONNIER C. Clinical relevance of cerebral small vessel diseases[J]. Stroke，2020，51（1）：47-53.
[2] WANG Z，CHEN Q，CHEN J J，et al. Risk factors of cerebral small vessel disease：a systematic review and meta-analysis[J/OL]. Medicine（Baltimore），2021，100（51）：e28229[2023-01-11]. https://doi.org/10.1097/MD.0000000000028229.
[3] DE GUIO F，DUERING M，FAZEKAS F，et al. Brain atrophy in cerebral small vessel diseases：extent，consequences，technical limitations and perspectives：the HARNESS initiative[J]. J Cereb Blood Flow Metab，2020，40（2）：231-245.
[4] BATH P M，WARDLAW J M. Pharmacological treatment and prevention of cerebral small vessel disease：a review of potential interventions[J]. Int J Stroke，2015，10（4）：469-478.
[5] MA H D，YANG Y，GAO M Z，et al. A novel rat model of cerebral small vessel disease and evaluation by super-resolution ultrasound imaging[J/OL]. J Neurosci Methods，2022，379：109673[2023-01-11]. https://doi.org/10.1016/j.jneumeth.2022.109673.
[6] YAN L，BAI C，ZHENG Y，et al. Study on the application of super-resolution ultrasound for cerebral vessel imaging in rhesus monkeys[J/OL].
Front Neurol，2021，12：720320[2023-01-11].
https://doi.org/10.3389/fneur.2021.720320.
[7] FERNÁNDEZ-ALVAREZ V，LINARES SÁNCHEZ M，LÓPEZ ALVAREZ F，et al. Evaluation of intima-media thickness and arterial stiffness as early ultrasound biomarkers of carotid artery atherosclerosis[J]. Cardiol Ther，2022，11（2）：231-247.
[8] INKERI J，TYNJÄLÄ A，FORSBLOM C，et al. Carotid intima-media thickness and arterial stiffness in relation to cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes[J]. Acta Diabetol，2021，58（7）：929-937.
[9] ZHANG K X，JIANG Y F，WANG Y Z，et al. Associations of arterial stiffness and carotid atherosclerosis with cerebral small vessel disease in a rural community-based population[J]. J Atheroscler Thromb，2020，27（9）：922-933.
[10] DELLA-MORTE D，DONG C，MARKERT M S，et al. Carotid intima-media thickness is associated with white matter hyperintensities：the Northern Manhattan study[J]. Stroke，2018，49（2）：304-311.
[11] ZHENG K，QIAN Y J，LIN T K，et al. Carotid intima-media thickness relative to cognitive impairment in dialysis patients，and their relationship with brain volume and cerebral small vessel disease[J/OL]. Ther Adv Chronic Dis，2020，11：2040622320953352[2023-01-01]. https://doi.org/10.1177/2040622320953352.
[12] GUSTAVSSON A M，VAN WESTEN D，STOMRUD E，et al. Midlife atherosclerosis and development of Alzheimer or vascular dementia[J]. Ann Neurol，2020，87（1）：52-62.
[13] BRISSET M，BOUTOUYRIE P，PICO F，et al. Large-vessel correlates of cerebral small-vessel disease[J]. Neurology，2013，80（7）：662-669.
[14] LI J，WU H Q，HANG H L，et al. Carotid vulnerable plaque coexisting with cerebral small vessel disease and acute ischemic stroke：a Chinese atherosclerosis risk evaluation study[J]. Eur Radiol，2022，32（9）：6080-6089.
[15] FAN X Y，ZHANG X Q，LAI Z C，et al. Cerebral small vessel disease burden related to carotid intraplaque hemorrhage serves as an imaging marker for clinical symptoms in carotid stenosis[J/OL]. Front Neurol，2021，12：731237[2023-01-11]. https://doi.org/10.3389/fneur.2021.731237.
[16] DE HAVENON A，WONG K H，ELKHETALI A，et al. Carotid artery stiffness accurately predicts white matter hyperintensity volume 20 years later：a secondary analysis of the atherosclerosis risk in the community study[J]. AJNR Am J Neuroradiol，2019，40（8）：1369-1373.
[17] ROBERT C，LING L H，TAN E S J，et al. Effects of carotid artery stiffness on cerebral small-vessel disease and cognition[J/OL]. J Am Heart Assoc，2022，11（23）：e027295[2023-01-11]. https://doi.org/10.1161/JAHA.122.027295.
[18] CHUANG S Y，WANG P N，CHEN L K，et al. Associations of blood pressure and carotid flow velocity with brain volume and cerebral small vessel disease in a community-based population[J]. Transl Stroke Res，2021，12（2）：248-258.
[19] PAULSON O B，STRANDGAARD S，EDVINSSON L. Cerebral autoregulation[J]. Cerebrovasc Brain Metab Rev，1990，2（2）：161-192.
[20] LIU Z J，MA H Y，GUO Z N，et al. Impaired dynamic cerebral autoregulation is associated with the severity of neuroimaging features of cerebral small vessel disease[J]. CNS Neurosci Ther，2022，28（2）：298-306.
[21] ROBERTSON A D，ATWI S，KOSTOGLOU K，et al. Cerebrovascular pulsatility during rest and exercise reflects hemodynamic impairment in stroke and cerebral small vessel disease[J]. Ultrasound Med Biol，2019，45（12）：3116-3127.
[22] MOK V，DING D，FU J H，et al. Transcranial Doppler ultrasound for screening cerebral small vessel disease：a community study[J]. Stroke，2012，43（10）：2791-2793.
[23] LEE K J，JUNG K H，PARK C Y，et al. Increased arterial pulsatility and progression of single subcortical infarction[J]. Eur Radiol，2017，27（3）：899-906.
[24] KIM Y，LEE H，AN S A，et al. The effect of pulsatility index on infarct volume in acute lacunar stroke[J]. Yonsei Med J，2016，57（4）：950-955.
[25] ELYAS S，ADINGUPU D，AIZAWA K，et al. Cerebral small vessel disease，systemic vascular characteristics and potential therapeutic targets[J]. Aging（Albany NY），2021，13（18）：22030-22039.
[26] VINCIGUERRA L，LANZA G，PUGLISI V，et al. Transcranial Doppler ultrasound in vascular cognitive impairment-no dementia[J/OL]. PLoS One，2019，14（4）：e0216162[2023-01-11]. https://doi.org/10.1371/journal.pone.0216162.
[27] JOVANOVIĆ Z B，PAVLOVIĆ A M，PEKMEZOVIĆ T，et al. Transcranial Doppler assessment of cerebral vasomotor reactivity in evaluating the effects of vinpocetine in cerebral small vessel disease：a pilot study[J]. Ideggyogy Sz，2013，66（7/8）：263-268.
[28] FISSE A L，PUESCHEL J，DEPPE M，et al. TCD-profiling using AVERAGE. A new technique to evaluate transcranial Doppler ultrasound flow spectra of subjects with cerebral small vessel disease[J]. Cerebrovasc Dis，2016，41（1/2）：50-59.
[29] PAVLOVIĆ A M，PEKMEZOVIĆ T，JOVANOVIĆ Z，et al. Transcranial parenchymal sonographic findings in patients with cerebral small vessel disease：a preliminary study[J]. J Ultrasound Med，2015，34（10）：1853-1859.
[30] MEJIA-RENTERIA H，TRAVIESO A，MATÍAS-GUIU J A，et al. Coronary microvascular dysfunction is associated with impaired cognitive function：the cerebral-coronary connection study（C3 study）[J]. Eur Heart J，2023，44（2）：113-125.
[31] XIAO C Y，MA Y H，OU Y N，et al. Association between kidney function and the burden of cerebral small vessel disease：an updated meta-analysis and systematic review[J]. Cerebrovasc Dis，2023，52（4）：376-386.
[32] 白永杰，张笑娜，王浏瑛，等. 扩大的血管周围间隙与动脉粥样硬化性血管狭窄的相关性分析[J]. 广东医学，2020，41（6）：589-593.
BAI Y J，ZHANG X N，WANG L Y，et al. Correlation analysis between enlarged perivascular space and large artery atherosclerotic stenosis[J]. Guangdong Medical Journal，2020，41（6）：589-593.
[33] ZHAI F F，YANG M，WEI Y，et al. Carotid atherosclerosis，dilation，and stiffness relate to cerebral small vessel disease[J/OL]. Neurology，2020，94（17）：e1811-e1819[2023-01-11]. https://doi.org/10.1212/WNL.0000000000009319.
[34] HAN F，ZHANG D D，ZHAI F F，et al. Association between large artery stenosis，cerebral small vessel disease and risk of ischemic stroke[J]. Sci China Life Sci，2021，64（9）：1473-1480.
[35] CHEN X D，LU D L，GUO N，et al. Left ventricular ejection fraction and right atrial diameter are associated with deep regional CBF in arteriosclerotic cerebral small vessel disease
[J/OL]. BMC Neurol，2021，21（1）：67[2023-01-11].
https://doi.org/10.1186/s12883-021-02096-w.
[36] LAHIRI S，SCHLICK K H，PADRICK M M，et al. Cerebral pulsatility index is elevated in patients with elevated right atrial pressure[J]. J Neuroimaging，2018，28（1）：95-98.
[37] NAVARRO K S，WONG K H，IBRAHIM M M，et al. The association between transthoracic echocardiogram parameters and white matter hyperintensities[J/OL]. Clin Neurol Neurosurg，2021，206：106672[2023-01-11]. https://doi.org/10.1016/j.clineuro.2021.106672.
[38] 金玲，刘运海，黄清. 心房颤动伴发脑小血管病的研究进展[J]. 中南大学学报（医学版），2022，47（2）：258-264.
JIN L，LIU Y H，HUANG Q. Research progress in atrial fibrillation with cerebral small vessel disease[J]. Journal of Central South University（Medical Science），2022，47（2）：258-264.
[39] RENSMA S P，VAN SLOTEN T T，HOUBEN A J H M，et al. Microvascular dysfunction is associated with worse cognitive performance：the Maastricht study[J]. Hypertension，2020，75（1）：237-245.
[40] KE L S，GUO Y Y，GENG X L. Value of color Doppler ultrasonography for diagnosing early diabetic nephropathy[J]. Iran J Kidney Dis，2022，16（5）：284-291.
[41] YAO T T，SONG G P，LI Y H，et al. Chronic kidney disease correlates with MRI findings of cerebral small vessel disease[J]. Ren Fail，2021，43（1）：255-263.
[42] PETRUCCI I，CLEMENTI A，SESSA C，et al. Ultrasound and color Doppler applications in chronic kidney disease[J]. J Nephrol，2018，31（6）：863-879.
[43] ÖLMEZ B，TOGAY IŞIKAY C，PEKER E，et al. The relationship between renal function and imaging markers and total burden of cerebral small vessel disease[J]. Neurologist，2022，27（4）：157-163.
[44] LEE E J，JEONG H B，BAE J，et al. Renal dysfunction is associated with middle cerebral artery pulsatility index and total burden of cerebral small vessel disease[J]. Cerebrovasc Dis，2021，50（6）：722-728.