Research Progress on the Role of Platelet Activation in Acute Cerebral Infarction

doi:10.3969/j.issn.1673-5765.2024.05.014

Abstract

Abstract: Acute cerebral infarction is a common ischemic cerebrovascular disease and is closely related to platelet activity. Platelet activity has significant impact on occurrence, development, treatment and prognosis of acute cerebral infarction. Mean platelet volume (MPV)and platelet distribution width (PDW) are two important indicators that reflect platelet activity. Platelets with larger volume are considered to have higher activity for they can secrete more thrombosis factors and express more P-selections and platelet glycoprotein Ⅱb/Ⅲa receptors. Activated platelets increase PDW by protruding pseudopodia of varying sizes. Thus, both high MPV and PDW are the indications of platelet activation. This paper reviewed the effects of platelet activation on the occurrence, development and prognosis of acute cerebral infarction, in order to provide references for the subsequent study of the relationship between platelet activity and acute cerebral infarction.

Key words: Platelet activation; Mean platelet volume; Platelet distribution width; Acute cerebral infarction

摘要： 急性脑梗死是常见的缺血性脑血管病，与血小板活性密切相关。血小板活性在急性脑梗死发病、进展、治疗及预后等环节均存在重要影响。平均血小板体积（mean platelet volume，MPV）和血小板分布宽度（platelet distribution width，PDW）是反映血小板活性的两个重要指标，体积大的血小板因能分泌更多的促血栓因子、表达更多的P-选择素和血小板糖蛋白Ⅱb/Ⅲa受体而被认为拥有更高的活性；活化的血小板因伸出大小不一的伪足而使得PDW增大，因此高MPV值和高PDW值都是血小板活化的标志。本文对血小板活化对急性脑梗死的发生、发展及预后等方面的影响进行综述，以期为后续研究血小板活性和急性脑梗死的关系提供参考。

关键词: 血小板活化; 平均血小板体积; 血小板分布宽度; 急性脑梗死

CLC Number:

ZHANG Jiancun, WANG Xinxing, TONG Haibo. Research Progress on the Role of Platelet Activation in Acute Cerebral Infarction[J]. Chinese Journal of Stroke, 2024, 19(5): 579-585.

张建村, 王新星, 仝海波. 血小板活化在急性脑梗死中的作用研究进展[J]. 中国卒中杂志, 2024, 19(5): 579-585.

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