Chinese Journal of Stroke ›› 2024, Vol. 19 ›› Issue (7): 747-754.DOI: 10.3969/j.issn.1673-5765.2024.07.003

Previous Articles     Next Articles

Moyamoya Angiopathy and Immune-Related Diseases

WANG Minjie1,2, HAN Cong1,2, DUAN Lian1,2   

  1. 1 Department of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing 100039, China

    2 Department of Neurosurgery, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China

  • Received:2024-04-30 Online:2024-07-20 Published:2024-07-20
  • Contact: DUAN Lian, E-mail: duanlian307@sina.com

烟雾血管病与免疫相关疾病

汪敏杰12,韩聪12,段炼1,2   

  1. 1 北京 100039 中国人民解放军总医院第一医学中心神经外科医学部

    2 中国人民解放军总医院第五医学中心神经外科

  • 通讯作者: 段炼 duanlian307@sina.com

Abstract: Moyamoya angiopathy (MMA) is an intracranial large artery occlusive disease of unknown etiology, characterized by chronic stenosis/occlusion of the internal carotid artery system and the formation of abnormal vascular networks. Clinical and epidemiological studies have demonstrated that patients with MMA have a higher prevalence of immune-related diseases, suggesting that immune factors play an important role in the occurrence and progression of MMA. This paper aims to review the correlation between MMA and immune-related diseases such as infections, vasculitis, and autoimmune diseases, and explore the potential mechanisms of immune-related diseases involved in the pathogenesis of MMA.

不同类型的烟雾血管病可能有不同的引起血管狭窄和低灌注状态的病因及发病环节,也可能出现侧支血管形成等脑缺血、缺氧后共同的代偿反应,免疫炎症可能是其中一种重要的触发因素。

Key words: Moyamoya angiopathy; Infection; Inflammation; Autoimmune disease

摘要: 烟雾血管病是一类病因不明的颅内大动脉闭塞性疾病,主要表现为颈内动脉系统慢性狭窄、闭塞和异常血管网的形成。临床和流行病学研究发现,烟雾血管病患者具有较高的免疫相关疾病患病率,提示免疫因素在烟雾血管病的发生、发展中扮演了重要角色。本文旨在对烟雾血管病与感染、血管炎及自身免疫性疾病等免疫相关疾病的相关性研究展开综述,探讨免疫相关疾病参与烟雾血管病发病的潜在机制。

关键词: 烟雾血管病; 感染; 炎症; 自身免疫性疾病

CLC Number: