The Power of Changing Guidelines: Two Decades of Key Clinical Trials on Ischemic Cerebrovascular Disease in China

doi:10.3969/j.issn.1673-5765.2025.05.002

Abstract

Abstract: Over the past two decades, China has made remarkable strides in clinical research on cerebrovascular disease, gradually shifting from relying on foreign research achievements to an international research model led by Chinese researchers. The CHANCE study marks the starting point of this progress, and with the introduction of other landmark studies, China has increasingly gained prominence in the global cerebrovascular disease research community. A series of key Chinese clinical studies have directly revised both national and international cerebrovascular disease guidelines. This article reviews the important clinical studies on ischemic cerebrovascular disease in China over the past two decades, explores the evidence-based basis for changing guidelines, and discusses future research directions, aiming to further advance the high-quality development of clinical research on ischemic cerebrovascular disease in China.

Key words: Ischemic cerebrovascular disease; Clinical research; Guideline; China

摘要： 过去20年，中国脑血管病临床研究取得了显著进步，逐步从依赖国外研究成果向以中国学者为主导的国际化研究模式转变。CHANCE研究标志着这一进步的起点，随着其他标志性研究的推出，中国逐渐在全球脑血管病研究领域占据重要地位，一系列中国临床研究直接改写了国内外脑血管病相关诊疗指南。本文回顾中国近20年缺血性脑血管病领域的重要临床研究，探讨其改变指南的循证依据，并展望未来研究方向，以期进一步推动中国缺血性脑血管病临床研究的高质量发展。

关键词: 缺血性脑血管病; 临床研究; 指南; 中国

CLC Number:

TAN Zefeng, XU Anding. The Power of Changing Guidelines: Two Decades of Key Clinical Trials on Ischemic Cerebrovascular Disease in China[J]. Chinese Journal of Stroke, 2025, 20(5): 529-548.

谭泽锋, 徐安定. 改变指南的力量——近20年中国缺血性脑血管病重磅临床研究[J]. 中国卒中杂志, 2025, 20(5): 529-548.

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