Abstract: There are three major examination methods of diagnosis patent foramen ovale (PFO):transesophageal echocardiography (TEE), transthoracic echocardiography (TTE) and transcranialDoppler ultrasonography (TCD). Recently, contrast ultrasonography is applied extensively inclinical diagnosis, and it improves the diagnostic accuracy of PFO significantly. The paper willsummarize the value of three contrast enhanced ultrasound methods in diagnosing of PFO, andprovide more accurate and effective information for the clinicians.

Key words: Brain infarction; Heart septai defects; atrial; Ultrasonography; interventional; Angiography

摘要： 目前评价缺血性卒中患者卵圆孔未闭（patent foramen ovale，PFO）的影像学检查方法主要有经食管超声心动图、经胸超声心动图及经颅多普勒超声等。近年来随着超声造影技术的发展，超声造影技术已被用于PFO疾病的诊断，明显提高了PFO诊断的准确率。本文旨在综述超声造影技术的原理以及PFO的各种超声检查技术利弊，为临床医生提供更加确切有效的信息。

关键词: 脑梗死; 房间隔缺损; 超声检查; 介入性; 血管造影术