中国卒中杂志 ›› 2024, Vol. 19 ›› Issue (9): 1012-1017.DOI: 10.3969/j.issn.1673-5765.2024.09.005

• 专题论坛 • 上一篇    下一篇

纳米材料在缺血性卒中诊疗中的研究进展及挑战

张丽苹1*,曹黎明2*,肖楠1,3,廖雨琦1,池枫1,余艳妮1,3,任力杰1(*第一作者)   

  1. 1 深圳 518035 深圳大学第一附属医院(深圳市第二人民医院)神经内科

    2 长沙医学院 3 深圳大学医学部

  • 收稿日期:2024-07-29 出版日期:2024-09-20 发布日期:2024-09-20
  • 通讯作者: 任力杰 renlijie72@126.com
  • 基金资助:

    广东省自然科学基金面上项目(2314050000154)

    深圳市优秀科技创新人才培养博士基础研究启动项目(RCBS20210609104631086)

    深圳市第二人民医院(深圳大学第一附属医院)“有组织医学科学研究行动计划”项目(2024YZZ01

Research Progress and Challenges of Nanomaterials in the Diagnosis and Treatment of Ischemic Stroke

ZHANG Liping1*, CAO Liming2*, XIAO Nan1,3, LIAO Yuqi1, CHI Feng1, YU Yanni1,3, REN Lijie1 (*contributed equally).   

  1. Department of Neurology, the First Affiliated Hospital of Shenzhen University (Shenzhen Second People’s Hospital), Shenzhen 518035, China;

    Changsha Medical University, Changsha 410219, China;

    Shenzhen University Medical School, Shenzhen 518060, China

  • Received:2024-07-29 Online:2024-09-20 Published:2024-09-20
  • Contact: REN Lijie, E-mail: renlijie72@126.com

摘要: 卒中是中国居民致死和长期致残的主要原因,传统的治疗药物受限于血脑屏障阻碍、稳定性差、缺乏靶向性、低载药量,治疗效果可能欠理想。纳米材料作为一种新兴的、非侵入性、可实时控制的药物,已被广泛用于卒中的诊疗。纳米药物能够有效提高药物的生物相容性、稳定性、靶向性,并延长药物的半衰期,从而有效改善传统药物的疗效。近年来纳米材料在缺血性卒中诊疗领域取得了一定进展,但仍面临临床转化等挑战。本文主要综述纳米材料在缺血性卒中诊疗中的研究进展和挑战,旨在继续推动纳米材料在卒中诊疗中的研究与应用。

文章导读: 纳米材料可弥补常规药物的不足,在个体化与精准诊疗方面为改善缺血性卒中的诊疗展现了光明前景。尤其是新型纳米材料能够克服传统成像方法的局限性,实现更早期的诊断,并实时监测药物释放,为缺血性卒中的治疗提供了新的方向。

关键词: 缺血性卒中; 纳米材料; 血脑屏障; 靶向治疗; 诊疗; 挑战

Abstract: Stroke is a major cause of death and long-term disability among residents in China. Traditional therapeutic drugs are limited by the obstruction of the blood-brain barrier, poor stability, lack of targeting, and low drug loading, which may result in suboptimal treatment outcomes. Nanomaterials, as an emerging, non-invasive, and real-time controllable drug delivery system, have been widely used in the diagnosis and treatment of stroke. Nanomedicines can effectively enhance the biocompatibility, stability, and targeting of drugs, as well as prolong their half-life, thereby significantly improving the efficacy of traditional medications. In recent years, there has been some progress in the application of nanomaterials in the field of ischemic stroke diagnosis and treatment, although challenges in clinical translation remain. This article primarily reviews the research progress and challenges of nanomaterials in the diagnosis and treatment of ischemic stroke, aiming to further promote the research and application of nanomaterials in stroke therapy.

Key words: Ischemic stroke; Nanomaterial; Blood-brain barrier; Targeted therapy; Diagnosis and treatment; Challenge

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