关键词: 普罗布考; 脑梗塞; 基质金属蛋白酶-9

Abstract: Objective To observe the effect of probucol on the level of MMP-9 in acute stage of cerebral infarction.Methods Using a random and single blind control test ,82 patients with cerebral infarction in acute stage were randomed into probucol group (n=42) and control group (n=40). With the method of ELISA, the levels of MMP-9in serum were measured before and after therapy.Results (1) The serum MMP-9 levels of Probucol group pre-treatment was 398.67±84.92ng/ml, two weeks after treatment 173.80±55.68ng/ml, significantly lower than that before treatment (P<0.05); The serum MMP-9 levels of control group pre-treatment serum levels was 401.12±62.56ng/ml, two weeks after treatment 352.98±89.65ng/ml, no significant difference between before and after treatment (P>0.05); (2) At the end of two weeks after treatment, the serum MMP-9levels of robucol group was significantly lower than that of control group (P<0.05).Conclusion Probucol can reduce the level of MMP-9 in acute stage of cerebra linfarction, thus may relieve the ischemic brain injury.

Key words: 【Key Words】 Probucol; Brain infarction; Matrix metalloproteinase 9