基于文献计量学分析缺血性脑血管病预后的基因组学研究

doi:10.3969/j.issn.1673-5765.2023.03.005

摘要/Abstract

摘要： 目的分析2017—2022年缺血性脑血管病（ischemic cerebrovascular disease，ICVD）预后的基因组学研究现状、研究热点及前沿领域。
方法在Web of Science核心合集（SCI-EXPANDED）中检索2017年1月1日—2022年10月1日ICVD预后的基因组学相关文献。使用CiteSpace软件分析文献中发文国家、机构、作者间的合作网络；参考文献、参考文献第一作者、期刊的共被引网络；参考文献的聚类结果；关键词的共现网络及其聚类结果，并使用可视化图谱呈现结果。
结果共纳入353篇文献。中国发文144篇，居全球首位，但仅与5个国家建立了合作关系。首都医科大学是发文最多的机构，共20篇。国际卒中遗传学联盟成员在发文量前10位的作者中占据6位，是发文的主力军并形成了主要的合作团簇。研究方法多使用全基因组关联分析和孟德尔随机化。近年来的研究热点是探究卒中预后与其他复杂疾病的共同遗传通路、影响抗血小板药物疗效的遗传变异，以及炎症机制在预后中的影响。
结论 ICVD预后的基因组学研究热度逐年上升，已形成多个研究热点，主要探索相关潜在机制来推动新药研发。

文章导读： 本文分析了2017—2022年缺血性脑血管病预后的基因组学研究合作现状及其原因，揭示了研究的前沿领域及多个热点方向。

关键词: 缺血性脑血管病; 预后; 基因组学; 文献计量学

Abstract: Objective To analyze the current research status, hotspots, and frontier fields of genomics studies on the prognosis of ischemic cerebrovascular disease (ICVD) from 2017 to 2022.
Methods The related English literature of genomics in the field of ICVD was retrieved in the Web of Science Core Collection (SCI-EXPANDED) from January 1, 2017 to October 1, 2022. CiteSpace software was used to analyze the cooperation network among the publishing countries, institutions and authors; the co-citation network of reference, first author of reference and journals; clustering results of references; the co-occurrence network of keywords and their clustering results. The results were presented by visual maps.
Results A total of 353 papers were included in this study. China ranked the first in the world with 144 articles, but only with five countries with cooperation partnership. Capital Medical University was the most prolific institution, with 20 articles. Six of the top ten authors were from members of the International Stroke Genetics Consortium (ISGC) , who were the main contributors and formed major cooperation clusters. Genome-wide association analysis (GWAS) and Mendelian randomization were the most commonly used research methods. In recent years, the hotspots focused on exploring the common genetic pathways of stroke prognosis and other complex diseases, genetic variation affecting the efficacy of antiplatelet drugs, and the influence of inflammatory mechanism on prognosis.
Conclusions The genomics studies of ICVD prognosis, which explore the underlying mechanism to facilitate new drugs development, have gained the popularity year by year and formed several research hotspots.

Key words: Ischemic cerebrovascular disease; Prognosis; Genomics; Bibliometrics

勾岚, 许喆, 李兰欣, 石延枫, 刘阳, 赵曼曼, 李昊, 程丝. 基于文献计量学分析缺血性脑血管病预后的基因组学研究[J]. 中国卒中杂志, 2023, 18(03): 266-272.

GOU Lan, XU Zhe, LI Lanxin, SHI Yanfeng, LIU Yang, ZHAO Manman, LI Hao, CHENG Si. The Bibliometrics-based Genomics Studies on Prognosis of Ischemic Cerebrovascular Disease[J]. Chinese Journal of Stroke, 2023, 18(03): 266-272.

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