中国卒中杂志 ›› 2013, Vol. 8 ›› Issue (04): 316-321.

• 综述 • 上一篇    下一篇

缺血性卒中与免疫反应

王继先1,张博爱2,杨国源1,3   

  1. 1200025 上海
    上海交通大学附属瑞金
    医院神经内科
    2郑州大学第一附属医院
    神经内科
    3上海交通大学Med-X研
    究院和生物医学工程学
  • 收稿日期:2012-10-09 出版日期:2013-04-20 发布日期:2013-04-20
  • 通讯作者: 杨国源 gyyang0626@gmai.com

Ischemic Stroke and Immune Reaction

  1. *Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong
    University, Shanghai 200025, China
  • Received:2012-10-09 Online:2013-04-20 Published:2013-04-20

摘要:

【摘要】 免疫和炎症反应是缺血性卒中病理过程的重要组成部分,自然免疫和适应性免疫都参与 这一过程。免疫反应不仅仅造成炎性损伤,引起外周血和免疫器官出现相应的免疫调节,还在缺血 性脑损伤后的脑组织修复和重建中发挥重要作用。抑制缺血诱导的炎症反应和进行免疫调节具有脑 保护和脑组织修复/重建作用,可能是缺血性脑损伤的一种新的治疗途径。目前关于缺血性脑损伤 的免疫治疗还存在诸多问题,需要深入了解免疫系统功能和脑缺血损伤之间的相互作用,以确保免疫 治疗的可行性、有效性和安全性。

文章导读: 本文介绍了缺血性卒中的免疫反应过程及作用,分析了免疫治疗从实验到临床的进展。

关键词: 细胞因子; 炎症介质; 免疫; 缺血性卒中

Abstract:

【Abstract】 Immunity, including innate and adaptive immunity, and inflammation response are important pathological process during ischemic stroke. This process not only leads to inflammatory damages and corresponding modulations in the peripheral blood and immune organs, but also plays a crucial role in the brain tissue repair and reconstruction. Suppression of inflammation and immunomodulation exert remarkable neuroprotection, providing a novel approach for the treatment of ischemic brain injury. However, there are many problems in immune therapy for the ischemic brain injury. The interaction between immune system and ischemic brain injury needs to be further studied to ensure the efficacy and safety of immunotherapy.

Key words: Cytokine; Inflammatory mediator; Immunity; Ischemic stroke