高血压患者双侧颈动脉血流和形态的偏侧差异性分析

doi:10.3969/j.issn.1673-5765.2017.05.009

摘要/Abstract

摘要：

目的探讨高血压对双侧颈动脉血流动力学及动脉壁厚度的影响差异。方法纳入原发性高血压患者52例为高血压组,健康体检者46例为健康组。应用彩色多普勒超声分别检测两组患者左右侧颈总动脉搏动指数（pulsatility index，PI）、阻力指数（resistance index，RI）、动脉血流收缩期峰值（peak systolic velocity，PSV）、舒张末期的谷值（end diastolic velocity，EDV）和内- 中膜厚度（i nti ma-media thickness，IMT）。对比两组组内左右侧颈动脉上述指标的差异，以及两组组间同侧颈动脉上述指标的差异。结果高血压组颈总动脉P（I P=0.019）、RI（P=0.012）及IMT（P=0.043）均为左侧大于右侧，而两侧血流速度无显著差异。健康组左右侧颈总动脉上述各项指标均无显著差异。高血压组双侧IMT、RI均显著高于健康组同侧颈总动脉，其中左侧IMT P =0.002，右侧IMT P =0.017，左侧RI P =0.023，右侧RI P =0.024，同时左侧PI高于健康组（P =0.011），而两组间血流速度无显著差异。结论原发性高血压对颈动脉血流动力学及形态学影响左侧大于右侧。

文章导读： 本研究对单纯高血压患者和健康对照人群进行了颈动脉彩色超声检查，结果显示高血压对左侧颈动脉的损伤要早于右侧，主要表现在搏动指数和阻力指数升高，而且动脉内中膜厚度也高于右侧。

关键词: 高血压; 颈动脉; 血流动力学; 内-中膜厚度

Abstract:

Objective To investigate the effect difference of hypertension on the hemodynamics and wall thickness of bilateral carotid arteries. Methods All subjects were divided into two groups: fifty-two hypertension patients in hypertension group and forty-six healthy people as control. The pulsatility index (PI), resistance index (RI), peak systolic velocity (PSV), end diastolic velocity (EDV), and intima-media thickness (IMT) of bilateral common carotid arteries of all subjects were detected by color Doppler ultrasound. The above indexes were compared to analyze the difference between left and right carotid artery in two groups, and ipsilateral difference between the two groups. Results In hypertension group: the PI (P =0.019), RI (P =0.012) and IMT (P =0.043) of common carotid artery were greater on the left side than that on the right side, while there was no significant difference in blood flow velocity (PSV, EDV) between both sides (P >0.05). In healthy group: there were no significant difference in all the indexes of carotid artery between two sides (P >0.05). Comparing the two groups, the results were that IMT and RI of common carotid artery in hypertension group were higher than that of ipsilateral artery in healthy group (left IMT: P =0.002; right IMT: P =0.017; left RI: P =0.023; right RI: P =0.024), while the PI difference was only found on the left side (hypertension group > healthy group: P =0.011). There were no significant difference in EDV and PSV between the two groups (P >0.05).

Conclusion The influence of primary hypertension on the hemodynamics and wall thickness of carotid artery on the left side was greater than on the right side.

Key words: Hypertension; Carotid artery; Hemodynamics; Intima-media thickness (IMT)

姜帆，卢柳西，姜中碧，田梦婕，金戈，李兴贵，展群岭. 高血压患者双侧颈动脉血流和形态的偏侧差异性分析[J]. 中国卒中杂志, 2017, 12(05): 421-424.

JIANG Fan, LU Liu-Xi, JIANG Zhong-Bi, et al. Analysis of Effect Difference of Hypertension on Hemodynamics and Wall Thickness of Bilateral Carotid Arteries[J]. Chinese Journal of Stroke, 2017, 12(05): 421-424.

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