中国卒中杂志 ›› 2024, Vol. 19 ›› Issue (7): 785-789.DOI: 10.3969/j.issn.1673-5765.2024.07.008

• 论著 • 上一篇    下一篇

甘油三酯对高血压患者认知功能的影响:一项社区人群的长期队列研究

贾娇坤1,刘改芬2,刘艳芳1,赵性泉1,陈静3   

  1. 1 北京 100070 首都医科大学附属北京天坛医院神经病学中心

    2 首都医科大学附属北京天坛医院,北京市脑血管病防治办公室

    3 北京市昌平区北七家社区卫生服务中心

  • 收稿日期:2024-04-09 出版日期:2024-07-20 发布日期:2024-07-20
  • 通讯作者: 赵性泉 zxq@vip.163.com 陈静 chenjingcp1216@163.com
  • 基金资助:

    脑卒中高危人群筛查和干预项目(财政部、国家卫生计生委[2015]82号;财政部、国家卫生健康委、国家疾控局[2023]63号)

    首都医科大学附属北京天坛医院苗圃工程项目(2023MP05

Effect of Triglyceride on Cognitive Function in Hypertensive Patients: A Long-Term Cohort Study in a Community-Based Population

JIA Jiaokun1, LIU Gaifen2, LIU Yanfang1, ZHAO Xingquan1, CHEN Jing3   

  1. 1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

    2 Beijing Cerebrovascular Disease Prevention and Control Office, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

    3 Beiqijia Community Health Service Center, Changping District, Beijing 102209, China

  • Received:2024-04-09 Online:2024-07-20 Published:2024-07-20
  • Contact: ZHAO Xingquan, E-mail: zxq@vip.163.com Chen Jing, E-mail: chenjingcp1216@163.com

摘要:

目的       探讨TG水平对社区高血压患者认知功能的影响。

方法       本研究为基于社区人群的前瞻性队列研究,研究对象为北京市昌平区北七家社区卫生服务中心辖区内40岁以上常住居民中的高血压患者。20152016年完成首次人口学、既往病史、实验室检查、认知功能评价(采用MoCA评估)等信息采集。随访78年,于2023年随访认知功能,以△MoCA(基线MoCA评分-随访MoCA评分)评估研究对象的认知功能下降情况。采用多因素线性回归探讨TG水平对认知功能下降的影响。

结果       研究共纳入338例患者,平均年龄为(59.1±6.8)岁,男性111例(32.8%)。TG水平与认知功能下降(△MoCA)呈正相关(β=0.172P=0.025),且主要与视空间执行功能下降相关(β=0.152P=0.045)。

结论       社区高血压患者TG水平升高与认知功能下降独立相关,且可能主要影响视空间执行功能。

文章导读: 本研究是基于大型数据库对社区居民的健康调查,结果提示社区高血压患者的TG水平与认知障碍具有相关性,且TG水平对视空间执行功能的影响更显著。

关键词: 甘油三酯; 认知障碍; 视空间执行功能; 高血压

Abstract:

Objective  To investigate the effects of TG levels on cognitive function in community patients with hypertension.

Methods  This study was a prospective cohort study based on community population. The subjects were hypertensive over 40 years old in Beiqijia Community Health Service Center, Changping District, Beijing. The first collection of information on demographics, medical history, laboratory tests, and assessment of cognitive function (using the MoCA) was completed from 2015 to 2016. Cognitive function was reassessed in 2023 after a follow-up of 7-8 years. Cognitive decline was defined as ΔMoCA (baseline MoCA scorefollow-up MoCA score). Multivariate linear regression was used to analyze the effects of TG levels on cognitive decline.

Results  A total of 338 patients [mean age (59.1±6.8) years, 111(32.8%) males] were included. TG levels were positively correlated with cognitive decline (ΔMoCA) (β=0.172, P=0.025), and were mainly correlated with the decline of visuospatial executive function (β=0.152, P=0.045). 

Conclusions  There is an independent correlation between the increased TG level and the decreased cognitive function in community patients with hypertension, and it may primarily affect the visuospatial executive function.

Key words: Triglyceride; Cognitive impairment; Visuospatial executive function; Hypertension

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