基于社区人群的性别与颈动脉粥样硬化斑块内出血关系的研究

doi:10.3969/j.issn.1673-5765.2019.01.008

摘要/Abstract

摘要：

目的探讨性别与通过HR-MRI诊断颅外颈动脉粥样硬化斑块内出血之间的关系。方法在清华大学社区人群中进行横断面调查，通过现场调查问卷获得人口统计学、既往史、行为生活方式、实验室检查结果等信息，根据HR-MRI对颅外颈动脉粥样硬化斑块内出血进行判读，分为斑块内出血组和无斑块内出血组。采用多因素Logistic回归分析探讨性别与斑块内出血之间的关系。结果本研究共纳入246例有颈动脉粥样硬化斑块的研究对象，男性105例（42.7%），平均年龄（64.8±11.5）岁，其中12例（4.88%）有斑块内出血。与无斑块内出血组相比，斑块内出血组男性较多（83.3% vs 40.6%，P =0.004），高血压病史（91.7% vs 43.2%，P =0.001）和糖尿病病史（50.0% vs 12.4%，P <0.001）的比例较高；空腹血糖[（6.30±1.63）mmol/L vs（5.00±0.99）mmol/L，P <0.001] 的水平较高。多因素Logistic回归分析发现，男性是颅外颈动脉粥样硬化斑块内出血的独立危险因素（OR 7.68，95%CI 1.10～53.81，P =0.040）。结论男性可能是颅外颈动脉粥样硬化斑块内出血的危险因素。

文章导读： 本研究在社区人群中探讨了性别和高分辨率磁共振诊断的颈动脉粥样硬化斑块内出血的关系，结果提示男性是颅外颈动脉斑块内出血的独立危险因素。

关键词: 性别; 颈动脉; 动脉粥样硬化; 斑块内出血; 危险因素

Abstract:

Objective To investigate the association between sex and intra-plaque hemorrhage (IPH) in carotid artery diagnosed by HR-MRI in a community-based population. Methods A cross-sectional study was conducted in Tsinghua community-based population. Data of demographic information, medical history of hypertension, diabetes and hyperlipidemia, smoking and drinking, physical examinations, laboratory test and other information were collected. According to whether there was IPH in carotid artery by HR-MRI, all subjects were classified as IPH group and no IPH group. Multivariate logistic regression analysis was performed to analyze the association of sex and IPH. Results Of all 246 participants, with 105 (42.7%) were males and a mean age of 64.8 years. There were 12 (4.88%) subjects with IPH. Comparing with the no IPH group, the IPH group had more males (83.3% vs 40.6%, P =0.004), a higher proportion of hypertension (91.7% vs 43.2%, P =0.001) and diabetes mellitus (50.0% vs 12.4%, P <0.001), a higher level of fasting blood glucose [(6.30±1.63) mmol/L vs (5.00±0.99) mmol/L, P <0.001]. The multivariate logistic analysis showed that sex was an independent risk factor of IPH in carotid artery (OR 7.68, 95%CI 1.10-53.81, P =0.040).

Conclusions Male may be an independent risk factor of IPH in carotid artery.

Key words: Sex; Carotid artery; Atherosclerotic plaque; Intra-plaque hemorrhage; Risk factor

王宇，张润华，姜勇，于淼欣，洪音，王畇，乔会昱，韩永军，李东野，赵锡海，王拥军，刘改芬. 基于社区人群的性别与颈动脉粥样硬化斑块内出血关系的研究[J]. 中国卒中杂志, 2019, 14(01): 43-48.

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