Chinese Journal of Stroke ›› 2017, Vol. 12 ›› Issue (06): 538-543.DOI: 10.3969/j.issn.1673-5765.2017.06.014

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Advances in the Imaging Studies on Association between Carotid Atherosclerotic Plaque Progression and Ischemic Cerebrovascular Events

  

  • Received:2016-06-23 Online:2017-06-20 Published:2017-06-20

颈动脉粥样硬化斑块进展与脑缺血事件相关性的影像学研究进展

陈潇祎,庄仲,赵锡海   

  1. 1100069 北京首都医科大学北京脑重大疾病研究院
    2齐齐哈尔市第一医院磁共振室
    3清华大学生物医学影像研究中心
  • 通讯作者: 赵锡海 xihaizhao@tsinghua.edu.cn
  • 基金资助:

    国家自然科学基金面上项目(81271536,81361120402)

Abstract:

The progression of carotid atherosclerotic plaques plays an important role in the pathophysiological process of ischemic cerebrovascular events. The progression of atherosclerotic plaque is characterized as wall thickening, luminal stenosis or occlusion, enlargement of lipidrich necrotic core, intraplaque hemorrhage, and fibrous cap disruption, et al. With the development of vascular imaging techniques, prospective studies aimed to assess plaque progression have been extensively performed. A number of studies have demonstrated that atherosclerotic plaque progression is significantly associated with future cerebrovascular events. This review will summarize the reproducibility of various imaging modalities in measuring carotid plaque progression and relationships between plaque progression and ischemic cerebrovascular events. This review will be helpful for better understanding the development of cerebrovascular disease and provide vital evidence for disease prevention.

Key words: Carotid artery; Atherosclerotic plaque; Progression; Imaging; Stroke

摘要:

颈动脉粥样硬化斑块进展是导致缺血性脑血管事件的重要病理生理过程。斑块进展可 表现为管壁增厚、管腔狭窄或闭塞、脂质核增大、斑块内出血、纤维帽破裂等特征。随着血管影像技 术的发展,以评价斑块进展为目的的前瞻性研究越来越广泛。大量研究表明,斑块进展与未来脑血 管事件的发生显著相关。本文将对评价斑块的影像学方法的可重复性以及斑块进展与未来脑血管 事件相关性影像学研究进展进行综述,旨在更好地理解脑血管病的发病过程,并为疾病的预防提供 重要依据。

关键词: 颈动脉; 粥样硬化斑块; 进展; 影像学; 脑血管病