Progress of Correlation between ABO Blood Group & ABO Gene and Cerebral Ischemic Stroke

doi:10.3969/j.issn.1673-5765.2018.04.015

Abstract

Abstract:

Recent studies have shown that non-O blood group (A, B or AB) had a higher risk of ischemic stroke than the O blood group in the ABO blood group system, indicating that the ischemic stroke had a correlation with ABO blood group, which may be due to the ABO blood group and effects of genes by plasma von Willebrand factor, low density lipoprotein cholesterin, and inflammatory factors such as soluble select E, soluble select P, Soluble intercellular adhesion molecule 1. Tumor necrosis factor-α and mediated the occurrence of ischemic stroke. Genome-wide association study also have confirmed that ABO blood group gene single nucleotide polymorphism loci was associated with cerebral ischemic stroke. This paper reviews the ABO blood group and the correlation between gene and ischemic stroke of the latest research progress.

Key words: ABO blood group; Gene; Ischemic stroke

摘要：

最近研究表明ABO血型系统中的非O血型（A、B或AB）人群相比O血型人群有更高的缺血性卒中发病风险，说明缺血性卒中与ABO血型具有相关性，而这种相关性可能是由于ABO血型及基因通过影响血浆血管性血友病因子、低密度脂蛋白胆固醇以及炎症因子如可溶性E-选择素、可溶性P-选择素、可溶性细胞间黏附因子1、肿瘤坏死因子-α的水平而介导缺血性卒中的发生。全基因组相关性研究也证实ABO血型基因存在与缺血性卒中相关的单核苷酸多态性位点，本文综述了ABO血型及基因与缺血性卒中的相关性的最新研究进展。

关键词: ABO血型; 基因; 缺血性卒中

WEI Wan, ZHANG Hao, JIANG Min-Hai. Progress of Correlation between ABO Blood Group & ABO Gene and Cerebral Ischemic Stroke[J]. Chinese Journal of Stroke, 2018, 13(04): 384-388.

魏婉, 张灏, 蒋敏海. ABO血型及基因与缺血性卒中的相关性研究进展[J]. 中国卒中杂志, 2018, 13(04): 384-388.

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