Progress of Vascular Cognitive Impairment and Its Functional Imageology

doi:10.3969/j.issn.1673-5765.2018.07.012

Abstract

Abstract:

The prevalence of vascular cognitive impairment (VCI) is increasing year by year, and it has become the main cause of disability among the elderly. However, there are still in lack of effective treatment. In recent years, magnetic resonance technology has developed rapidly, especially functional imageology, such as blood oxygen level dependent function magnetic resonance imaging (BLOD-fMRI), magnetic resonance spectroscopy (MRS), and perfusion weighted imaging (PWI), which can evaluate the patient’s brain function with the advantages of high resolution, non-traumatic and so on. It provides an imaging evidence for early recognition, differential diagnosis and prognosis evaluation of vascular cognitive impairment, etc.

Key words: Vascular cognitive impairment; Functional magnetic resonance; Magnetic resonance spectroscopy; Perfusion weighted imaging

摘要：

血管性认知障碍（vascular cognitive impairment，VCI）患病率逐年增加，现已成为老年人群中主要的致残原因，但目前尚缺乏有效的治疗手段。近年来磁共振成像技术迅速发展，尤其是功能影像学，如血氧水平依赖功能磁共振（blood oxygen level dependent functional magnetic resonance i magi ng，BLOD-fMRI）、磁共振波谱技术(magnetic resonance spectroscopy，MRS)、灌注加权成像技术（perfusion weighted imaging，PWI）等，以其高分辨、非创伤性等优点对患者的脑功能进行评价，为血管性认知障碍早期识别、鉴别诊断及评估预后等方面提供了影像学依据。

关键词: 血管性认知障碍; 功能磁共振; 磁共振波谱技术; 灌注加权成像技术

HE Meng-Fei, YIN Chang-Hao, CAO Wen-Hui, SUN Weng-Qiang, ZHAO Wei-Na. Progress of Vascular Cognitive Impairment and Its Functional Imageology[J]. Chinese Journal of Stroke, 2018, 13(07): 697-700.

贺梦菲, 尹昌浩, 曹文慧, 孙文强, 赵维纳. 血管性认知障碍及其功能影像学的研究进展[J]. 中国卒中杂志, 2018, 13(07): 697-700.

References

[1] 中华医学会神经病学分会痴呆与认知障碍学组写作

组. 血管性认知障碍诊治指南[J]. 中华神经科杂志，

2011，44（2）：142-147.

[2] KEOGH-BROWN M R，TARP J H，MICHAEL A

H，et al. The Impact of Alzheimer's Disease on the

Chinese Economy[J/OL]. Ebiomedicine，2016，4：

184-190. https：//doi.org/10.1016/j.ebiom.2015.12.019.

[3] ROSENBERG G A，WALLIN A，Wardlaw J M，et

al. Consensus statement for diagnosis，of subcortical

small vessel disease[J]. J Cereb Blood Flow Metab，

2016，36（1）：6-25.

[4] 国家卫计委脑卒中防治工程委员会. 中国血管性认

知障碍诊疗指导规范（2016年）[J]. 全科医学临床与

教育，2016，14（5）：484-487.

[5] SACHDEV P，KALARIA R，O’BRIEN J，et al.

Diagnostic criteria for vascular cognitive disorders：

a VASCOG statement[J]. Alzheimer Dis Assoc

Disord，2014，28（3）：206.

[6] 史嫣慧，徐娅萍. 功能性磁共振成像检查在耳鸣中的

应用研究进展[J]. 浙江医学，2017，39（2）：142-145.

[7] 张碧云，陈自谦，李铭山. 正电子发射断层成像技术

和功能磁共振成像技术在中枢神经系统中的应用进

展[J]. 医学研究生学报，2008，21（2）：210-214.

[8] 李惠，徐向阳. 血管性认知障碍的磁共振研究进

展[J]. 实用放射学杂志，2014（12）：2084-2086.

[9] 林海龙，薛蕴菁，康正武，段青. 静息态fMRI在无

痴呆型血管性认知障碍基线脑活动变化中的初步

研究[J]. 临床放射学杂志，2013，32（8）：1070-1074.

[10] SCHAEFER A，QUINQUE E M，KIPPING J A，et

al. Early small vessel disease affects frontoparietal

and cerebellar hubs in close correlation with clinical

symptoms--a resting-state fMRI study[J]. J Cereb

Blood Flow Metab，2014，34（7）：1091-1095.

[11] VENKATRAMAN V K，AIZENSTEIN H，

GURALNIK J，et al. Executive control function，

brain activation and white matter hyperintensities

in older adults[J]. Neuroimage，2010，49（4）：3436-

3442.

[12] HAFKEMEIJER A，VAN D G J，ROMBOUTS S

A. Imaging the default mode network in aging and

dementia[J]. Biochimica Et Biophysica Acta，2012，

1822（3）：431-441.

[13] 马思懿，张宗军. 皮质下血管性认知功能障碍的脑默

认网络静息态功能磁共振研究[J]. 医学影像学杂志，

2015（2）：189-193.

[14] HERMINGHAUS S，FRÖLICH L，GORRIZ

C，et al. Brain metabolism in Alzheimer disease

and vascular dementia assessed by in vivo proton

magnetic resonance spectroscopy[J]. Psychiatry Res，

2003，123（3）：183-190.

[15] PILATUS U，LAIS C，ROCHMONT A M，et al.

Conversion to dementia in mild cognitive impairment

is associated with decline of N-actylaspartate

and creatine as revealed by magnetic resonance

spectroscopy[J]. Psychiatry Res，2009，173（1）：1-7.

[16] ZHU X，CAO L，HU X，et al. Brain metabolism

assessed via proton magnetic resonance spectroscopy

in patients with amnestic or vascular mild cognitive

impairment[J/OL]. Clin Neurol Neurosurg，2014，130：

80-85. https：//doi.org/10.1016/j.clineuro.2014.12.005.

[17] LIU Y Y，YANG Z X，SHEN Z W，et al. Magnetic

Resonance Spectroscopy Study of Amnestic Mild

Cognitive Impairment and Vascular Cognitive

Impairment With No Dementia[J]. Am J Alzheimers

Dis Other Demen，2013，29（5）：474-481.

[18] 李新文，巩尊科，王世雁，等. MRS在非痴呆型血管

性认知障碍评定中的临床应用研究[J]. 徐州医学院

学报，2017，37（4）：248-251.

[19] PETCHARUNPAISAN S，RAMALHO

J，CASTILLO M. Arterial spin labeling in

neuroimaging[J]. World J Radiology，2010，2（10）：

384.

[20] SUN Y，CAO W，DING W，et al. Cerebral Blood

Flow Alterations as Assessed by 3D ASL in

Cognitive Impairment in Patients with Subcortical

Vascular Cognitive Impairment：A Marker for

Disease Severity[J/OL]. Front Aging Neurosci，2016，

8：211. https：//doi.org/10.3389/fnagi.2016.00211.

[21] GAO Y Z，ZHANG J J，LIU H，et al. Regional

cerebral blood flow and cerebrovascular reactivity

in Alzheimer's disease and vascular dementia

assessed by arterial spinlabeling magnetic resonance

imaging[J]. Curr Neurovasc Res，2013，10（1）：49-

53.