[1] BENETOLI A,PAGANELLI R A,GIORDANIF,et al. Effect of tacrolimus(FK506)on ischemiainducedbrain damage and memory dysfunction inrats[J]. Pharmacol Biochem Behav,2004,77(3):607-615.[2] BENETOLI A,DUTRA A M,PAGANELLI R A,et al. Tacrolimus(FK506)reduces hippocampaldamage but fails to prevent learning and memorydeficits after transient,global cerebral ischemia inrats[J]. Pharmacol Biochem Behav,2007,88(1):28-38.[3] LI Z,WANG Y,XIE Y,et al. Protective effectsof exogenous hydrogen sulfide on neurons ofhippocampus in a rat model of brain ischemia[J].Neurochem Res,2011,36(10):1840-1849.[4] HERMAWATI E,ARFIAN N,MUSTOFA,et al.Spatial memory disturbance following transient brainischemia is associated with vascular remodelingin hippocampus[J]. Kobe J Med Sci,2018,64(3):E93-E106.[5] OGUNDELE O M,AJONIJEBU D C,ADENIYI PA,et al. Cerebrovascular changes in the rat brain intwo models of ischemia[J]. Pathophysiology,2014,21(3):199-209.[6] SUN Y Y,LI Y,WALI B,et al. Prophylacticedaravone prevents transient hypoxic-ischemicbrain injury:implications for perioperativeneuroprotection[J]. Stroke,2015,46(7):1947-1955.[7] LU F,NAKAMURA T,TOYOSHIMA T,et al.Edaravone,a free radical scavenger,attenuatesbehavioral deficits following transient forebrainischemia by inhibiting oxidative damage in gerbils[J].Neurosci Lett,2012,506(1):28-32.[8] NOOR J I,IKEDA T,MISHIMA K,et al. Shorttermadministration of a new free radical scavenger,edaravone,is more effective than its long-termadministration for the treatment of neonatal hypoxicischemicencephalopathy[J]. Stroke,2005,36(11):2468-2474.[9] UENO Y,ZHANG N,MIYAMOTO N,et al.Edaravone attenuates white matter lesions throughendothelial protection in a rat chronic hypoperfusionmodel[J]. Neuroscience,2009,162(2):317-327.[10] ZHANG D,XIAO Y,LV P,et al. Edaravoneattenuates oxidative stress induced by chroniccerebral hypoperfusion injury:role of ERK/Nrf2/HO-1 signaling pathway[J]. Neurol Res,2018,40(1):1-10.[11] LI X,LU F,LI W,et al. Edaravone injectionreverses learning and memory deficits in a rat model
of vascular dementia[J]. Acta Biochim Biophys Sin(Shanghai),2017,49(1):83-89.[12] JIAO L,ZHANG J,LI Z,et al. Edaravone alleviatesdelayed neuronal death and long-dated cognitivedysfunction of hippocampus after transient focalischemia in Wistar rat brains[J]. Neuroscience,2011,182(5):177-183.[13] OKUYAMA S,MORITA M,SAWAMOTO A,etal. Edaravone enhances brain-derived neurotrophicfactor production in the ischemic mouse brain[J].Pharmaceuticals(Basel),2015,8(2):176-185.[14] LI C,MO Z,LEI J,et al. Edaravone attenuatesneuronal apoptosis in hypoxic-ischemic braindamage rat model via suppression of TRAILsignaling pathway[J]. Int J Biochem Cell Biol,2018,99(6):169-177.[15] BROWN A G,THAPA M,HOOKER J W T,etal. Impaired chemoreflex correlates with decreasedc-Fos in respiratory brainstem centers of thestreptozotocin-induced Alzheimer's disease ratmodel[J]. Exp Neurol,2019,311(1):285-292.[16] MORRIS G P,CLARK I A,VISSEL B. Questionsconcerning the role of amyloid-beta in the definition,aetiology and diagnosis of Alzheimer's disease[J].Acta Neuropathol,2018,136(5):663-689.[17] REETA K H,SINGH D,GUPTA Y K. Edaravoneattenuates intracerebroventricular streptozotocininducedcognitive impairment in rats[J]. Eur JNeurosci,2017,45(7):987-997.[18] ZHOU S,YU G,CHI L,et al. Neuroprotectiveeffects of edaravone on cognitive deficit,oxidativestress and tau hyperphosphorylation induced byintracerebroventricular streptozotocin in rats[J].Neurotoxicology,2013,38(9):136-145.[19] JIAO S S,YAO X Q,LIU Y H,et al. Edaravonealleviates Alzheimer's disease-type pathologies andcognitive deficits[J]. Proc Natl Acad Sci USA,2015,112(16):5225-5230.[20] YANG R,WANG Q,LI F,et al. Edaravoneinjection ameliorates cognitive deficits in rat modelof Alzheimer's disease[J]. Neurol Sci,2015,36(11):2067-2072.[21] 陈奎. 依达拉奉治疗轻、中度阿尔茨海默病55例疗效观察[J]. 内科,2011,6(6):571-572.[22] 成战强. 依达拉奉对轻中度阿尔茨海默病患者认知功能的保护作用研究[J]. 中国合理用药探索,2019,16(4):19-21.[23] 赵仲艳,刘涛,赵二义,等. 依达拉奉对阿尔茨海默病患者氧化应激和氧自由基代谢的影响[J]. 解放军医药杂志,2019,31(12):64-68.[24] 李明秋,黄海华,牟鑫,等. 依达拉奉治疗轻、中度阿尔茨海默病的临床对照观察[J]. 实用医学杂志,2010,26(24):4574-4576.[25] TIAN A,MA H,ZHANG R,et al. Edaravoneimproves spatial memory and modulates endoplasmicreticulum stress-mediated apoptosis after abdominalsurgery in mice[J]. Exp Ther Med,2017,14(1):355-360.[26] WANG P,CAO J,LIU N,et al. Protective effectsof edaravone in adult rats with surgery andlipopolysaccharide administration-induced cognitivefunction impairment[J/OL]. PLoS One,2016,11(4):e0153708[2019-11-05]. https://doi.org/10.1371/journal.pone.0153708.[27] OGASAWARA K,YAMADATE K,KOBAYASHIM,et al. Effects of the free radical scavenger,edaravone,on the development of postoperativecognitive impairment in patients undergoing carotidendarterectomy[J]. Surg Neurol,2005,64(4):309-313.[28] OHTA M,HIGASHI Y,YAWATA T,et al.Attenuation of axonal injury and oxidative stress byedaravone protects against cognitive impairmentsafter traumatic brain injury[J]. Brain Res,2013,1490(1):184-192.[29] 赵雅宁,郭霞,高俊玲,等. 依达拉奉对大鼠重型弥漫性脑创伤后细胞外信号调节激酶1/2信号通路的影响[J]. 中国危重病急救医学,2010,22(4):230-233.[30] LI J M,ZHANG P,ZHAO Y N,et al. Protectiveeffects of edaravone on diffuse brain injury in rats[J].World J Emerg Med,2011,2(3):222-227.[31] TUPKOVIC E,SOFTIC R,KLEBIC J,et al. Posttraumaticstress disorder,metacognitions,cognitiveand global functioning in bosnian war veterans[J].Mater Sociomed,2019,31(4):258-261.[32] DIMITROVA L,FERNANDO V,VISSIA EM,et al. Sleep,trauma,fantasy and cognition indissociative identity disorder,post-traumatic stressdisorder and healthy controls:a replication andextension study[J/OL]. Eur J Psychotraumatol,2020,11(1):1705599[2019-11-05]. https://doi.org/10.1080/20008198.2019.1705599.[33] CHEN X,JIANG Y,WANG J,et al. Synapseimpairment associated with enhanced apoptosis inpost-traumatic stress disorder[J/OL]. Synapse,2020,74(2):e22134[2019-11-05]. https://doi.org/10.1002/syn.22134.[34] ALZOUBI K H,SHATNAWI A,AL-QUDAH MA,et al. Edaravone prevents memory impairment inan animal model of post-traumatic distress[J]. BehavPharmacol,2019,30(2 and 3-Spec Issue):201-207.
[35] CHEN Z,ZHANG J,CHEN Q,et al.Neuroprotective effects of edaravone afterintraventricular hemorrhage in rats[J]. Neuroreport,2014,25(9):635-640.[36] ZHANG J,SHI X,CHEN Z,et al. Edaravonereduces iron-mediated hydrocephalus and behavioraldisorder in rat by activating the Nrf2/HO-1pathway[J]. J Stroke Cerebrovasc Dis,2018,27(12):3511-3520.[37] ISHII J,NATSUME A,WAKABAYASHI T,et al.The free-radical scavenger edaravone restores thedifferentiation of human neural precursor cells afterradiation-induced oxidative stress[J]. Neurosci Lett,2007,423(3):225-230.[38] JANGRA A,SRIRAM C S,DWIVEDI S,et al.Sodium phenylbutyrate and edaravone abrogatechronic restraint stress-induced behavioral deficits:implication of oxido-nitrosative,endoplasmicreticulum stress cascade,and neuroinflammation[J].Cell Mol Neurobiol,2017,37(1):65-81.[39] JANGRA A,KWATRA M,SINGH T,etal. Edaravone alleviates cisplatin-inducedneurobehavioral deficits via modulation of oxidativestress and inflammatory mediators in the rathippocampus[J]. Eur J Pharmacol,2016,791(11):51-61.[40] MORI K,BEPPU T,FUJISAWA Y,et al. Effectof free radical scavenger,edaravone,for patientswith carbon monoxide poisoning[J]. Clin NeurolNeurosurg,2015,139(12):56-61.