Analysis of Factors Associated with 6-month Outcome in Postoperative Aneurysmal Subarachnoid Hemorrhage Patients Treated with Hyperbaric Oxygen and Rehabilitation Therapy

doi:10.3969/j.issn.1673-5765.2020.08.006

Abstract

Abstract:

Objective To identify the factors associated with 6-month outcome in postoperative aneurysmal subarachnoid hemorrhage (aSAH) patients treated with hyperbaric oxygen (HBO) and rehabilitation therapy. Methods A retrospective analysis of the data of postoperative aSAH patients treated with HBO and rehabilitation therapy at Rehabilitation Medicine Center of Fuxing Hospital, Capital Medical University between October 2014 and June 2019 was performed. Good outcome was defined as a postoperative 6-month mRS score of 0-3. Multivariate analysis was used to identify the factors affecting the 6-month prognosis. Results A total of 68 patients were included, with 33 males (48.5%) and a mean age of 57.0±11.6 years. 51.5% (35/68) patients had good prognosis at 6 months. Multivariate logistic regression analysis showed that NIHSS at admission (OR 2.131, 95%CI 1.532-2.876) and delayed cerebral ischemia (OR 1.743, 95%CI 1.203-2.145) were independent risk factors for poor prognosis. Conclusions For postoperative aSAH patients treated with hyperbaric oxygen and rehabilitation therapy, higher neurological deficit scores before rehabilitation and delayed cerebral ischemia were associated with 6-month unfavorable outcome.

Key words: Aneurysmal subarachnoid hemorrhage; Hyperbaric oxygen therapy; Prognosis;Rehabilitation

摘要：

目的探讨高压氧联合康复治疗动脉瘤性蛛网膜下腔出血术后患者6个月预后的影响因素。方法回顾性纳入2014年10月-2019年6月首都医科大学附属复兴医院康复中心连续收治的动脉瘤性蛛网膜下腔出血术后患者，均接受高压氧联合康复治疗至出院。收集患者临床资料，良好预后定义为术后6个月mRS评分0～3分。采用多因素Logistic回归分析影响6个月临床预后的相关因素。结果共纳入68例患者，平均年龄57.0±11.6岁，男性33例（48.5%）。6个月良好预后率为51.5% （35/68）。多因素Logistic回归分析显示，入院NIHSS评分（OR 2.131，95%CI 1.532～2.876）和迟发性脑缺血（OR 1.743，95%CI 1.203～2.145）为不良预后的独立影响因素。结论高压氧联合康复治疗的动脉瘤性蛛网膜下腔出血术后患者中，康复治疗前严重的神经功能缺损及迟发性脑缺血与其6个月不良预后相关。

关键词: 动脉瘤性蛛网膜下腔出血; 高压氧; 预后; 康复

SONG Lu, WANG Yong, LI Hai-Dong,GAO Ya-Li, LIU Jie, LI Zheng, LU Min-Jie, LIU Yue-Wei, ZHANG Xiao-Xiao. Analysis of Factors Associated with 6-month Outcome in Postoperative Aneurysmal Subarachnoid Hemorrhage Patients Treated with Hyperbaric Oxygen and Rehabilitation Therapy[J]. Chinese Journal of Stroke, 2020, 15(08): 848-852.

宋璐，王泳，李海东，高亚利，刘洁，李征，陆敏杰，刘月伟，张潇潇. 高压氧联合康复治疗动脉瘤性蛛网膜下腔出血术后患者6个月预后影响因素分析[J]. 中国卒中杂志, 2020, 15(08): 848-852.

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