Chinese Journal of Stroke ›› 2020, Vol. 15 ›› Issue (12): 1281-1286.DOI: 10.3969/j.issn.1673-5765.2020.12.005

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Advances in Machine Learning-based Neuroimaging Studies on Cognitive Impairment due to Cerebral Small Vessel Disease

  

  • Received:2020-07-01 Online:2020-12-20 Published:2020-12-20

基于机器学习的脑小血管病认知障碍影像研究进展

陆佩文,徐群   

  1. 1200127 上海交通大学医学院附属仁济医院神经内科
    2上海交通大学医学院附属仁济医院中澳神经认知中心
    3上海交通大学医学院附属仁济医院健康管理中心
  • 通讯作者: 徐群 xuqun@renji.com
  • 基金资助:

    上海市自然科学基金(19ZR1430500)
    上海市转化医学协同创新中心合作研究项目(TM201808)
    国家重点研发计划(2016YFC1300600)

Abstract:

Cerebral small vessel disease (CSVD) is the main cause of cognitive impairment. Some neuroimaging studies have found many changes in brain structure and function related to cognitive impairment due to CSVD at group level. However, it is hard to make individual evaluation for cognitive impairment and prognosis prediction according to these neuroimaging changes. In recent years, machine learning has been gradually applied to cerebrovascular disease field, and machine learning-based neuroimaging data analysis can be used to predict disease progression and find potential imaging biomarkers.

Key words: Cerebral small vessel disease; Cognitive impairment; Neuroimaging; Machine learning

摘要:

脑小血管病(cerebral small vessel disease,CSVD)是认知障碍的主要原因。神经影像研究已在组水平层面发现许多与CSVD认知障碍相关的大脑结构与功能的改变,然而难以实现个体化评价和预测。近年来,机器学习逐渐应用于脑疾病中,如利用神经影像数据对疾病进展进行个体化预测,发掘潜在的生物学标志物等方面。

关键词: 脑小血管病; 认知障碍; 神经影像; 机器学习