Chinese Journal of Stroke ›› 2021, Vol. 16 ›› Issue (01): 34-38.DOI: 10.3969/j.issn.1673-5765.2021.01.006

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Association between Red Blood Cell Distribution Width and Visual Impairment in Patients with Idiopathic Intracranial Hypertension

  

  • Received:2020-09-11 Online:2021-01-20 Published:2021-01-20

红细胞分布宽度与特发性颅高压患者视力下降的关系研究

田雨,管玲,陈洁,龚浠平,董可辉,莫大鹏,王伊龙   

  1. 1北京 100070首都医科大学附属北京天坛医院神经病学中心血管神经病学科
    2国家神经系统疾病临床医学研究中心
    3首都医科大学附属北京天坛医院神经介入中心
  • 通讯作者: 王伊龙 yilong528@aliyun.com 莫大鹏 modapeng1971@163.com
  • 基金资助:

    国家自然科学基金委员会杰出青年科学基金项目(81825007)
    北京高校卓越青年科学家计划项目(BJJWZYJH01201910025030)
    “十三五”国家重点研发计划(2017YFC1307900)
    北京市科学技术委员会北京市科技计划(D171100003017001)

    北京市科学技术委员会北京市优秀人才培养资助-青年拔尖团队(2016000021223TD03)
    北京市百千万人才工程培养经费资助-A创新研发类(2018A12)
    北京市医院管理局培训计划(PX2017009)

Abstract:

Objective To explore the association of red blood cell distribution width (RDW) and venous sinus stenosis with visual impairment in patients with idiopathic intracranial hypertension (IIH). Methods Data of patients with IIH at Department of Neurology of Beijing Tiantan Hospital, Capital Medical University from September 2011 to September 2018 were retrospectively analyzed. According to having visual impairment or not on admission, all the patients were divided into visual impairment group and no visual impairment group. The RDW level and venous sinus stenosis between the two groups were compared. The patients were divided into high RDW group and low RDW group based on median RDW, the visual loss was compared between the two groups. Results A total of 58 patients were included, with 41 cases in visual impairment group and 17 cases in no visual impairment group, 29 cases in high RDW group and 29 cases in low RDW group. Patients with impaired vision had higher blood RDW than those without impaired vision [43.60 (41.35-51.00) fL vs 40.90 (39.05-43.20) fL, P =0.008]. The proportion of having impaired vision in high RDW group was higher than that in low RDW group [25 (86.3%) vs 16 (55.2%), P =0.009]. Conclusions The level of RDW in IIH patients with visual impairment was higher than that in IIH patients without visual impairment.

Key words: Idiopathic intracranial hypertension; Red blood cell distribution width; Visual impairment

摘要:

目的 探讨特发性颅高压(idiopathic intracranial hypertension,IIH)患者血液红细胞分布宽度(red blood cell distribution width,RDW)、静脉窦狭窄情况与视力下降的关系。 方法 回顾性分析2011年9月-2018年9月连续就诊于首都医科大学附属北京天坛医院血管神经病 学科的IIH患者的临床资料。根据患者是否存在视力下降症状,将其分为非视力下降组和视力下降组, 对比两组患者的RDW水平和静脉窦狭窄情况;以RDW中位数为界限分为高RDW组和低RDW组,比较两 组视力下降症状出现的比例。 结果 共入组58例IIH患者,其中视力下降组41例,非视力下降组17例;高RDW组和低RDW组各29 例。视力下降组RDW水平高于非视力下降组[43.60(41.35~51.00)fL vs 40.90(39.05~43.20)fL, P =0.008]。高RDW组存在视力下降症状患者比例高于低RDW组[25(86.3%)vs 16(55.2%),P =0.009]。 结论 有视力下降的IIH患者的RDW水平高于无视力下降的患者。

关键词: 特发性颅高压; 红细胞分布宽度; 视力下降