Pathogenesis of Cancer-Associated Ischemic Stroke

doi:10.3969/j.issn.1673-5765.2021.02.003

Abstract

Abstract:

The pathogenesis of cancer-associated ischemic stroke is complicated, and cancerassociated mechanisms and a variety of traditional mechanisms are jointly involved in the occurrence of ischemic stroke. The mechanisms directly related to cancer include the direct effect of cancer, abnormal blood coagulation, nonbacterial thrombotic endocarditis, infection and endothelial cell injury; in addition, the cancer treatment, including chemotherapy, radiotherapy, endocrine therapy and invasive treatment, can also cause stroke through related pathophysiological mechanism. Some pathophysiological mechanisms interact each other and jointly contribute to the occurrence of ischemic stroke.

Key words: Cancer; Ischemic stroke; Pathogenesis

摘要：

肿瘤相关脑梗死的发病机制复杂，且肿瘤相关机制和多种传统机制共同参与脑梗死的发生。在肿瘤相关性卒中病因中，肿瘤的直接作用、凝血功能异常、非细菌性血栓性心内膜炎、感染和内皮损伤等机制都与肿瘤直接相关；而化疗、放疗、内分泌治疗和侵入性治疗等针对肿瘤的治疗也可通过相关的病理生理学机制引起脑梗死的发生。不同病理生理学机制相互交叉，共同导致了脑梗死的发生。

关键词: 肿瘤; 脑梗死; 发病机制

YANG Qi-Zhou, FU Rui, WANG Li-li. Pathogenesis of Cancer-Associated Ischemic Stroke[J]. Chinese Journal of Stroke, 2021, 16(02): 124-129.

杨启舟，付睿，王莉莉. 肿瘤相关脑梗死发病机制的研究进展[J]. 中国卒中杂志, 2021, 16(02): 124-129.

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