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中重度LA的独立危险因素。有研究提示,Hcy
在体内可以激活一系列较为复杂的反应,通过
抑制内皮型一氧化氮导致血脑屏障功能受限,
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综上所述,高龄与高血压是AIS静脉溶栓
患者中重度LA的独立危险因素,而Hcy水平升
高则是此类患者脑室旁中重度LA的独立危险
因素。但本研究仍存在一定的局限性:第一,本
研究为单中心研究,样本量有限,可能使研究
结果产生偏倚;第二,本研究为回顾性分析,未
对患者进行长期预后随访。因此,今后还需更
大规模、前瞻性的研究进一步探讨AIS静脉溶
栓患者LA的影响因素。
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