Chinese Journal of Stroke ›› 2022, Vol. 17 ›› Issue (03): 217-226.DOI: 10.3969/j.issn.1673-5765.2022.03.002
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Received:
2021-12-03
Online:
2022-03-20
Published:
2022-03-20
许喆, 程丝, 刘阳, 石延枫, 李昊
基金资助:
XU Zhe, CHENG Si, LIU Yang, SHI Yanfeng, LI Hao. Construction of Bioinformatics Pipeline for Genomics Data in Cerebral Vascular Disease Researches[J]. Chinese Journal of Stroke, 2022, 17(03): 217-226.
许喆, 程丝, 刘阳, 石延枫, 李昊. 脑血管病基因组学数据分析流程建设[J]. 中国卒中杂志, 2022, 17(03): 217-226.
[1] WU S M,WU B,LIU M,et al. Stroke in China:advances and challenges in epidemiology,prevention,and management[J]. Lancet Neurol,2019,18(4):394-405. [2] ADAMS H P JR,BENDIXEN B H,KAPPELLE L J,et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of org 10 172 in acute stroke treatment[J]. Stroke,1993,24(1):35-41. [3] DICHGANS M,PULIT S L,ROSAN D J . Stroke genetics:discovery,biology,and clinical applications[J]. Lancet Neurol,2019,18(6):587-599. [4] SHEN Y P,PENG C,BAI Q K,et al. Epigenomewide association study indicates hypomethylation of MTRNR2L8 in large-artery atherosclerosis stroke[J]. Stroke,2019,50(6):1330-1338. [5] VANLANDEWIJCK M,HE L,MÄE M A,et al. A molecular atlas of cell types and zonation in the brain vasculature[J]. Nature,2018,554(7693):475-480. [6] SADLER R,CRAMER J V,HEINDL S,et al. Short-chain fatty acids improve poststroke recovery via immunological mechanisms[J]. J Neurosci,2020,40(5):1162-1173. [7] HASIN Y,SELDIN M,LUSIS A. Multi-omics approaches to disease[J]. Genome Biol,2017,18(1):83. [8] EDDY S,MARIANI L H,KRETZLER M. Integrated multi-omics approaches to improve classification of chronic kidney disease[J]. Nat Rev Nephrol,2020,16(11):657-668. [9] MALIK R,DAU T,GONIK M,et al. Common coding variant in SERPINA1 increases the risk for large artery stroke[J]. Proc Natl Acad Sci USA,2017,114(14):3613-3618. [10] GUDBJARTSSON D F ,HOLM H ,GRETARSDOTTIR S,et al. A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke[J]. Nat Genet,2009,41(8):876-878. [11] International Stroke Genetics Consortium(ISGC),Wellcome Trust Case Control Consortium 2(WTCCC2),BELLENGUEZ C,et al. Genomewideassociation study identifies a variant in HDAC9 associated with large vessel ischemic stroke[J]. Nat Genet,2012,44(3):328-333. [12] KLEI N C J,MIDDHA S,DUAN X H,et al. Application of whole exome sequencing in undiagnosed inherited polyneuropathies[J]. J Neurol Neurosurg Psychiatry,2014,85(11):1265-1272. [13] ILINCA A,SAMUELSSON S,PICCINELLI P,et al. A stroke gene panel for whole-exome sequencing[J]. Eur J Hum Genet,2019,27(2):317-324. [14] FANG F,XU Z,SUO Y,et al. Gene panel for Mendelian strokes[J]. Stroke Vasc Neurol,2020,5(4):416-421. [15] MALIK R,CHAUHAN G,TRAYLOR M,et al. Multiancestry genome-wide association study of 520 000 subjects identifies 32 loci associated with stroke and stroke subtypes[J]. Nat Genet,2018,50(4):524-537. [16] WANG Y J,JING J,MENG X,et al. The third China national st roke regist ry(CNSR-Ⅲ)for patients with acute ischaemic stroke or transient ischaemic attack:design,rationale and baseline patient characteristics[J]. Stroke Vasc Neurol,2019,4(3):158-164. [17] CHENG S,XU Z,LIU Y,et al. Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack:design,methods and baseline patient characteristics[J]. Stroke Vasc Neurol,2021,6(2):291-297. [18] BERSANO A,MARKUS H S,QUAGLINI S,et al. Clinical pregenetic screening for stroke monogenic diseases:results from lombardia GENS registry[J]. Stroke,2016,47(7):1702-1709. [19] Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)Consor tium,the Stroke Genetics Network(SiGN),the International Stroke Genetics Consortium(ISGC). Identification of additional risk loci for stroke and small vessel disease:a metaanalysis of genome-wide association studies[J]. Lancet Neurol,2016,15(7):695-707. [20] BOYLE A P,HONG E L,HARIHARAN M,et al. Annotation of functional variation in personal genomes using regulomeDB[J]. Genome Res,2012,22(9):1790-1797. [21] CARITHERS L J,MOORE H M. The genotypetissue expression(GTEx)project[J]. Biopreserv Biobank,2015,13(5):307-308. [22] FISHILEVICH S,NUDEL R,RAPPAPORT N,et al. GeneHancer:genome-wide integration of enhancers and target genes in GeneCards[J/OL]. Database(Oxford),2017,2017:bax028[2021-12-01]. https://doi.org/10.1093/database/bax028. [23] LANDRUM M J,LEE J M,RILEY G R,et al. ClinVar:public archive of relationships among sequence variation and human phenotype[J/OL]. Nucleic Acids Res,2014,42(Database issue):D980-D985[2021-12-01]. https://doi.org/10.1093/nar/gkt1113.
[24] BLANKENBERG D,HILLMAN-JACKSON J. Analysis of next-generation sequencing data using Galaxy[J/OL]. Methods Mol Biol,2014,1150:21- |
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