Abstract: Atherosclerosis can cause cardiovascular and cerebrovascular diseases and do great harm tohuman health. Recent researches on the mechanisms of atherosclerosis show that oxidized lowdensity lipoprotein(ox-LDL) is one of the most important factors which cause the initiation anddevelopment of atherosclerosis. Researches on the new drugs that can inhibit the oxidation of lowdensity lipoprotein(LDL) will provide a new method to develop new drugs to protect the artery fromdeveloping atherosclerosis.

Key words: Atherosclerosis; Antioxidant; Oxidized low density lipoprotein

摘要： 动脉粥样硬化是心脑血管疾病的病理基础，多种因素可促进动脉硬化，近年愈来愈多的研究结果表明，低密度脂蛋白（LDL）被氧化修饰是导致动脉粥样硬化的重要原因，因此寻找有效地抑制低密度脂蛋白发生氧化修饰的药物，对于动脉粥样硬化的防治具有重要意义，研究一种能够抑制LDL转化为ox-LDL新药将成为治疗动脉粥样硬化新方法。

关键词: 动脉粥样硬化; 抗氧化剂; 氧化低密度脂蛋白