Abstract:

Objective To explore the possible risk factors for single seizure and recurrent seizures occurred in post-stroke cases in terms of seizure medical control and prevention purpose. Methods One hundred and twenty-two cases admitted into hospital with post-stroke seizures were included and followed up for six months to five years period(from 2004-2008) in this study. All included subjects were divided into two groups: single seizure group defined as unique seizure followed up at least six months(26 cases), while recurrent seizures defined as ≥2 seizures(96 cases). The demographic and clinical features, the seizure type and initial onset time, the infarct location and the electroencephalographic(EEG) findings were compared between the two groups. Results Univariately statistics indicated that patients with later onset post-stroke seizures(defined as seizures occurred >14 days after stroke) had a tend to be associated with recurrent seizures compared to patients with early onset one(defined as seizures occurred within 14 days after stroke). Meanwhile, final multiple regression model study further showed that recurrent seizures was greatly associated with partial seizures(OR=10.50; 95%CI 1.35-81.97) and late seizures(OR=3.628; 95%CI 1.237-10.638). Conclusion Patients with late post-stroke onset seizures or partial seizures are more at risk of recurrent seizures.

Key words: Stroke; Epilespsy; Risk factor; Recurrent

摘要：

目的 旨在通过回顾性研究卒中后癫发作及其复发情况，并分析其可能的影响因素，为临床治疗提供参考。 方法 将122例卒中后癫发作患者分组：单次癫发作（随访至少6个月只出现1次癫发作）组26例，癫发作复发（卒中后出现≥2次癫发作）组96例。观察患者的基础情况、卒中的危险因素、卒中的类型、癫发作的类型、发作频次、治疗等情况与复发的关系。 结果 性别、年龄、卒中的类型、卒中危险因素、卒中的部位以及脑电图改变在两组间无差异。晚发性癫发作、部分性癫发作以及接受治疗情况在组间有统计学差异（P<0.05～0.01）。Logistic多元回归提示晚发性癫发作是癫发作复发的危险因素之一，比值比为3.628；95%置信区间为1.237～10.638，部分性癫发作患者较全面性癫发作患者更易复发，比值比为10.50，95%置信区间为1.35～81.97。 结论 晚发性癫发作是癫发作复发的影响因素之一，部分性癫发作患者倾向于复发。

关键词: 卒中; 癫; 危险因素; 复发