Abstract: Objective To compare the clinical presentation, intracranial and extracranial artery stenosis, and the short-term outcomes in patients with basilar artery(BA) stenosis with those without BA stenosis, and to investigate the associations between BA stenosis and poor outcomes in the patients with isolated pontine infarction at discharge.Methods In this prospective study, we recruited patients who were hospitalized for isolated pontine infarction within 7 days of symptom onset from October 2007 to August 2008. We compared the differences in risk factors, clinical features, the baseline neurologic impairment and the outcomes at discharge in patients with and without BA stenosis.Results A total of 101 patients with isolated pontine infarction were included in this study. Differences in central facial palsy and dysphagia(P=0.008 and 0.002) were observed among the 2 groups(with and without moderate to severe BA stenosis/occlusion). When the 2 groups were compared, the neurological impairments on admission were more severe in patients with moderate to severe BA stenosis/occlusion than in patients without BA stenosis(P=0.002). Those with moderate to severe BA stenosis/occlusion had higher incidences of concomitant stenosis of intracranial and/or extracranial artery than those without BA stenosis(P=0.009). The multivariable logistic-regression analysis showed that the significant outcome differences between patients with and without moderate to severe BA stenosis/occlusion when adjusted for potential confoundingfactors(OR 2.7, 95%CI 1.07-7.02, P=0.04).Conclusions Patients of isolated pontine infarction with moderate to severe BA stenosis/occlusion had higher incidences of concomitant stenosis of other intracranial and/or extracranial artery. Moderate to severe BA stenosis/occlusion was an independent predictor for poor outcomes at discharge after stroke onset in patients with isolated pontine infarction.

Key words: Stenosis; basilar artery; Infarct; pontine; Prognosis

摘要： 目的 比较伴或不伴基底动脉狭窄的孤立性脑桥梗死患者的临床特征及合并其他颅内外动脉狭窄的情况，并分析基底动脉狭窄与患者出院时预后的相关性。方法 前瞻性收集了2007年10月至2008年8月北京天坛医院卒中单元连续收治的起病7天内急性孤立性脑桥梗死患者的临床及神经影像资料。比较伴或不伴基底动脉狭窄的危险因素、临床症状体征、神经功能缺损严重程度及出院时的预后情况。结果 共纳入101例孤立性脑桥梗死患者，与无或轻度基底动脉狭窄组患者相比，伴中、重度基底动脉狭窄或闭塞组患者，中枢性面瘫和吞咽困难的发生率高（P=0.008和0.002），入院时神经功能缺损较严重（P=0.002），同时合并其他颅内外动脉狭窄的比例也较高（P=0.009）。调整后的多因素分析显示：中、重度基底动脉狭窄或闭塞与孤立性脑桥梗死患者出院时预后不良相关（OR 2.7，95%CI 1.07～7.02，P=0.04）。结论 伴中、重度基底动脉狭窄或闭塞的孤立性脑桥梗死患者急性期神经功能缺损较严重，常合并其他颅内外动脉狭窄；中、重度基底动脉狭窄或闭塞是孤立性脑桥梗死患者出院时预后不良的独立预测因子。

关键词: 狭窄; 基底动脉; 梗死; 脑桥; 预后