Abstract: Objective To investigate the relationship between the microembolic signals(MESs) and the clinicalmanifestation and infarctions in patients with Moyamoya disease.Methods We reviewed 6 patients with Moyamoya disease in whom MESs was present duringtranscranial Doppler(TCD) test, to investigate the relationship between the MESs and the clinicalmanifestation and the distribution of infarctions on diffusion-weighted imaging(DWI).Results MES was present in the middle cerebral artery(MCA), 3(50%) of which are stenosis andothers are occlusive. Among the 6 patients, 5(83.33%) patients had recent clinical symptoms,3(50%) patients with symptoms compatible with ischemia in the MCA territory without MESs,1(16.67%) patient with symptoms in MCA territory with and without MESs, and 1(16.67%) patientwith symptoms in the posterior circulation. From DWI, 5/6(83.33%) patients showed infarctions,4(66.67%) patients showed infarctions in the MCA territory with MESs, and 5(83.33%) patientsshowed infarctions in the MCA territory without MESs. All the patients had multiple infarcts.Cortical infarcts were the most common.Conclusion MES can be detected in patients with Moyamoya disease, with or without recent symptoms.The relationship between MES and clinical manifestation and infarctions needs further study.

Key words: Moyamoya disease; Embolism; Microembolic signals; Cerebral ischemia

摘要： 目的 分析烟雾病患者的微栓子信号（microembolic signal，MES）与临床表现及梗死灶的关系。方法 总结了6例在常规经颅多普勒超声（transcranial Doppler，TCD）检查中出现MES的烟雾病患者的临床资料及弥散加权成像（diffusion-weighted imaging，DWI）影像资料，分析MES与患者临床表现及DWI上梗死灶之间的关系。结果 6例患者的MES均出现在大脑中动脉（middle cerebral artery，MCA），3例（50%）闭塞，3例（50%）狭窄。6例中5例（83.33%）患者一个月内出现过缺血性症状，其中3例（50%）症状发生在无MES侧MCA供血区域；1例（16.67%）症状交替发生在MES同侧或对侧MCA供血区；1例（16.67%）为后循环缺血。5例（83.33%）患者DWI上出现梗死灶，在MES同侧MCA供血区内出现梗死灶的共有4（66.67%）例，无MES侧MCA供血区内出现梗死灶的共有5例（83.33%）。均为（100%）多发性梗死，皮层梗死为最常见梗死类型。结论 无论近期是否出现过缺血症状，烟雾病患者狭窄或闭塞的MCA均可发现MES。这些MES的存在与临床症状及梗死灶的相关性有待进一步研究。

关键词: 烟雾病; 栓塞; 微栓子信号; 脑梗死