| 1Folkman J, Merler E, Abernathy C, et al. Isolation of a tumor factor responsible for angiogenesis[J]. J Exp Med, 1971, 133:275-288.2 Patan S. Vasculogenesis and angiogenesis as mechanisms of vascular network formation, growth and remodeling[J]. J Neurooncol, 2000, 50:1-15.3 Risau W. Mechanisms of angiogenesis[J]. Nature, 1997, 386:671-674.4 Greenberg DA. Angiogenesis and stroke[J]. Drug News Perspect, 1998, 11:265-270.5 Kilarski WW, Gerwins P. A new mechanism of blood vessel growth-hope for new treatment strategies[J]. Discov Med, 2009, 8:23-27.6 Makanya AN, Hlushchuk R, Djonov VG. Intussusceptive angiogenesis and its role in vascular morphogenesis, patterning, and remodeling[J]. Angiogenesis, 2009, 12:113-123.7 Caduff JH, Fischer LC, Burri PH. Scanning electron microscope study of the developing microvasculature in the postnatal rat lung[J]. Anat Rec, 1986, 216:154-164.8 Crivellato E, Nico B, Vacca A, et al. Recombinant human erythropoietin induces intussusceptive microvascular growth in vivo[J]. Leukemia, 2004, 18:331-336.9 Potente M, Gerhardt H, Carmeliet P. Basic and therapeutic aspects of angiogenesis[J]. Cell, 2011, 146:873-887.10 Krupinski J, Kaluza J, Kumar P, et al. Role of angiogenesis in patients with cerebral ischemic stroke[J]. Stroke, 1994, 25:1794-1798.11 Chen J, Zhang ZG, Li Y, et al. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats[J]. Circ Res, 2003, 92:692-699.12 Wang Z, Tsai LK, Munasinghe J, et al. Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke[J]. Stroke, 2012, 43:2430-2436.13 Zhang ZG, Chopp M. Neurorestorative therapies for stroke:underlying mechanisms and translation to the clinic[J]. Lancet Neurol, 2009, 8:491-500.14 Zhang Z, Chopp M. Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia[J]. Trends Cardiovasc Med, 2002, 12:62-66.15 Zhang ZG, Zhang L, Tsang W, et al. Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia[J]. J Cereb Blood Flow Metab, 2002, 22:379-392.16 Chen HH, Chien CH, Liu HM. Correlation between angiogenesis and basic fibroblast growth factor expression in experimental brain infarct[J]. Stroke, 1994, 25:1651-1657.17 Manoonkitiwongsa PS, Jackson-Friedman C, Mcmillan PJ, et al. Angiogenesis after stroke is correlated with increased numbers of macrophages:the clean-up hypothesis[J]. J Cereb Blood Flow Metab, 2001, 21:1223-1231.18 Wei L, Erinjeri JP, Rovainen CM, et al. Collateral growth and angiogenesis around cortical stroke[J]. Stroke, 2001, 32:2179-2184.19 Zhang ZG, Zhang L, Jiang Q, et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain[J]. J Clin Invest, 2000, 106:829-838.20 Guo H, Itoh Y, Toriumi H, et al. Capillary remodeling and collateral growth without angiogenesis after unilateral common carotid artery occlusion in mice[J]. Microcirculation, 2011, 18:221-227.21 Liman TG, Endres M. New vessels after stroke:postischemic neovascularization and regeneration[J]. Cerebrovasc Dis, 2012, 33:492-499.22 Oladipupo S, Hu S, Kovalski J, et al. VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting[J]. Proc Natl Acad Sci USA, 2011, 108:13264-13269.23 Kovacs Z, Ikezaki K, Samoto K, et al. VEGF and flt. Expression time kinetics in rat brain infarct[J]. Stroke, 1996, 27:1865-1872; discussion 1863-1872.24 Jin KL, Mao XO, Greenberg DA. Vascular endothelial growth factor:direct neuroprotective effect in in vitro ischemia[J]. Proc Natl Acad Sci USA, 2000, 97:10242-10247.25 Sun Y, Jin K, Xie L, et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia[J]. J Clin Invest, 2003, 111:1843-1851.26 Marti H J, Bernaudin M, Bellail A, et al. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia[J]. Am J Pathol, 2000, 156:965-976.27 Hayashi T, Abe K, Itoyama Y. Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia[J]. J Cereb Blood Flow Metab, 1998, 18:887-895.28 Yang JP, Liu HJ, Liu XF. VEGF promotes angiogenesis and functional recovery in stroke rats[J]. J Invest Surg, 2010, 23:149-155.29 Dietrich WD, Danton G, Hopkinsa C, et al. Thromboembolic events predispose the brain to widespread cerebral infarction after delayed transient global ischemia in rats[J]. Stroke, 1999, 30:855-861; discussion 862.30 Ginsberg MD, BustoR. Rodent models of cerebral ischemia[J]. Stroke, 1989, 20:1627-1642.31 Taguchi Y, Takashima S, Sasahara E, et al. Morphological changes in capillaries in the ischemic brain in Wistar rats[J]. Arch Histol Cytol, 2004, 67:253-261.32 Jin KL, Mao XO, Nagayama T, et al. Induction of vascular endothelial growth factor and hypoxia-inducible factor-1alpha by global ischemia in rat brain[J]. Neuroscience, 2000, 99:577-585.33 Lee MY, Ju WK, Cha J H, et al. Expression of vascular endothelial growth factor mRNA following transient forebrain ischemia in rats[J]. Neurosci Lett, 1999, 265:107-110. 34 Leon RL, Li X, Huber JD, et al. Worsened outcome from middle cerebral artery occlusion in aged rats receiving 17beta-estradiol[J]. Endocrinology, 2012, 153:3386-3393.35 Brenneman M, Sharma S, Harting M, et al. Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats[J]. J Cereb Blood Flow Metab, 2010, 30:140-149.36 Jin K, Mao X, Xie L, et al. Delayed transplantation of human neural precursor cells improves outcome from focal cerebral ischemia in aged rats[J]. Aging Cell, 2010, 9:1076-1083.37 Jin K, Minami M, Xie L, et al. Ischemia-induced neurogenesis is preserved but reduced in the aged rodent brain[J]. Aging Cell, 2004, 9:373-377.38 Shen F, Fan Y, Su H, et al. Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice[J]. Gene Ther, 2008, 15:30-39.39 Zhu W, Fan Y, Frenzel T, et al. Insulin growth factor-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice[J]. Stroke, 2008, 39:1254-1261.40 Kusaka N, Sugiu K, Tokunaga K, et al. Enhanced brain angiogenesis in chronic cerebral hypoperfusion after administration of plasmid human vascular endothelial growth factor in combination with indirect vasoreconstructive surgery[J]. J Neurosurg, 2005, 103:882-890.41 Bellomo M, Adamo EB, Deodato B, et al. Enhancement of expression of vascular endothelial growth factor after adeno-associated virus gene transfer is associated with improvement of brain ischemia injury in the gerbil[J]. Pharmacol Res, 2003, 48:309-317.42 Ozawa CR, Banfi A, Glazer NL, et al. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis[J]. J Clin Invest, 2004, 113:516-527.43 van Bruggen N, Thibodeaux H, Palmer JT, et al. VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain[J]. J Clin Invest, 1999, 104:1613-1620.44 Wang Y, Kilic E, Kilic U, et al. VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena[J]. Brain, 2005, 128:52-63.45 Ferrara N, Alitalo K. Clinical applications of angiogenic growth factors and their inhibitors[J]. Nat Med, 1999, 5:1359-1364.46 Simons M. Angiogenesis:where do we stand now?[J]. Circulation, 2005, 111:1556-1566. |
