Current Progress of Thymosin Beta 4 on Angiogenesis

Abstract

Abstract:

Thymosin beta 4 (Tβ4) is a pleiotropic peptide which is widely distributed in mammals and other vertebrates, and participates in several cellular events including promotion angiogenesis, new axon growth, cancerogenesis, wound healing and inhibition of inflammation. Due to the effects of Tβ4 in these events, it may become a new target site of stroke treatment. In this review we discuss the current state of knowledge regarding the effects of Tβ4 on angiogenesis.

Key words: Thymosin beta 4; Angiogenesis; Stroke

摘要：

胸腺素β4（thymosin beta4，Tβ4）作为一种多功能的多肽，广泛分布于哺乳动物和其他脊椎动物中。Tβ4的促进血管再生、神经轴突再生、肿瘤生长和伤口愈合、抑制炎症等功能已经成为国内外研究的焦点，并且Tβ4可能成为治疗卒中的新靶点。本文就Tβ4在血管再生中的研究进展做一综述。

关键词: 胸腺素β4; 血管再生; 卒中

PANG Yue-Shan, LUO Yong. Current Progress of Thymosin Beta 4 on Angiogenesis[J]. Chinese Journal of Stroke, 2013, 8(08): 680-683.

庞月珊，罗勇. 胸腺素β4在血管再生中的研究进展[J]. 中国卒中杂志, 2013, 8(08): 680-683.

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