Abstract:

【Abstract】 Objective To investigate the relationship between microalbuminuria (MAU) and the risk factors of acute ischemic stroke. Methods A prospective observation study was adopted in this study. One hundred and sixty-six consecutive patients with acute ischemic stroke were included and divided into two groups: MAU positive group (n =81) which was defined as MAU level 20~300 mg/L, and negative group (n =85) which was defined as MAU level <20 mg/L. The clinical data and laboratory results in two groups were compared. Results Diabetes (χ 2=8.116, P =0.004), systolic pressure (t =2.735, P =0.007), National Institutes of Health Stroke Scale (NIHSS) (t =2.612, P =0.01), fasting blood glucose (t =2.68, P =0.008), low density lipoprotein cholesterol (t =2.217, P =0.028) and C-reactive protein (t =5.548, P =0.000) in MAU positive group were significantly higher than those in MAU negative group. Logistic regression analysis shows diabetes ([odds ratio, OR] 1.51, 95%[confidence interval, CI] 1.26~2.47, P =0.01), systolic pressure (OR 1.47, 95%CI 1.01~1.17, P =0.004), low density lipoprotein cholesterol (OR 2.43, 95%CI 1.01~5.37, P =0.03) and C-reactive protein (OR 1.79, 95%CI 1.09~1.21, P =0.005) were dependent risk factors of MAU. Conclusion MAU increasing was related to the risk factors of ischemic stroke, including hypertension, diabetes, C-reactive protein and low density lipoprotein cholesterol. MAU increasing might indicate the severity of illness in patients with acute ischemic stroke.

Key words: Microalbuminuria; Ischemic infarction

摘要：

目的 探讨微量白蛋白尿（microalbuminuria，MAU）与急性脑梗死危险因素及其病情严重程度的关系。 方法 采用前瞻性研究方法，连续收集2011年7月～2013年7月在上海市第一人民医院分院神经内科 住院且发病时间72 h内的急性脑梗死患者166例为研究对象，其中男89例，女77例，应用免疫比浊法 测定患者的尿微量白蛋白水平，根据检测结果将所有患者分成MAU阳性组（81例）和MAU阴性组（85 例）。比较两组间一般临床资料及生化指标是否存在差异，并采用Logistic回归分析评估MAU与脑梗死 危险因素的相关性。 结果 166例患者中，有81例（48.8%）存在MAU。MAU阳性组与阴性组比较，糖尿病（χ2=8.116， P =0.004）、收缩压（t =2.735，P =0.007）、美国国立卫生研究院卒中量表（National Institutes of Health Stroke Scale，NIHSS）（t =2.612，P =0.01）、血糖（t =2.68，P =0.008）、低密度脂蛋白胆固醇（t =2.217， P =0.028）和C反应蛋白（t =5.548，P =0.000）差异有显著性。Logistic回归分析显示，糖尿病［优势比 （odds ratio，OR）为1.51，95%可信区间（confidence interval，CI）1.26～2.47，P =0.01］、收缩压（OR 1.47， 95%CI 1.01～1.17，P =0.004）、低密度脂蛋白胆固醇（OR 2.43，95%CI 1.01～5.37，P =0.03）和C反应蛋 白（OR 1.79，95%CI 1.09～1.21，P =0.005）均为MAU的独立危险因素。 结论 MAU与高血压、糖尿病、C反应蛋白、血脂等脑梗死危险因素密切相关。

关键词: 微量白蛋白尿; 脑梗死