Abstract: Objective To evaluate the efficacy and safety of escitalopram and sertraline in the treatment of senile post-stroke depression. Methods Eighty patients with senile post-stroke depression were divided into treatment group and control group with 40 cases in each. The treatment group was given escitalopram combined with routine cerebrovascular disease drug treatment, the control group received sertraline combined with routine cerebrovascular disease drug treatment. In the treatment of 1, 2, 4, 6 weeks, Hamilton Depression Scale (HAMD), National Institutes of Health Stroke Scale (NIHSS), Barthel index (BI) were used and their scores were compared. Results In the treatment group and the control group, HAMD, NIHSS scores were significantly improved, but no significant difference between groups, BI index difference had statistical significance in the treatment of the fourth and sixth week ( P =0.016, P =0.025). Conclusion Escitalopram have significant effects on treatment of senile post-stroke depression, and the ability of daily life is better than the sertraline group.

Key words: Escitalopram; Sertraline; Post-stroke depression, Senile; Effect

摘要： 目的 探讨艾司西酞普兰与盐酸舍曲林治疗老年性卒中后抑郁的有效性及安全性。 方法 将80例老年性卒中后抑郁患者随机分为艾司西酞普兰组 （10 mg/d） 和盐酸舍曲林组 （50 mg/d） ， 每组各40例， 疗程6周， 两组的基础治疗相同并辅以心理治疗。 在治疗第l、 2、 4、 6周， 盲法评定两组 的汉密尔顿抑郁量表 （Hamilton Depression Scale， HAMD） 、 美国国立卫生研究院卒中量表 （National Institutes of Health Stroke Scale， NIHSS） 、 贝斯指数 （Barthel index， BI） 并进行比较。 结果 艾司西酞普兰组与盐酸舍曲林组HAMD、 NIHSS评分在第2、 4、 6周较本组治疗前均有显著 降低 （ P 均＜0.001） ， 但组间无显著差异， 治疗第4、 6周艾司西酞普兰组BI指数高于盐酸舍曲林组 （ P =0.016， P =0.025） 。 结论 艾司西酞普兰与盐酸舍曲林结合心理治疗均能改善老年性卒中后抑郁症状和神经功能； 在短 期日常生活能力改善方面， 艾司西酞普兰优于盐酸舍曲林。

关键词: 艾司西酞普兰; 盐酸舍曲林; 卒中后抑郁; 老年; 疗效