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Table of Content

    20 August 2011, Volume 6 Issue 08
    述评
    Through the Clinical and Imaging Features of Dysphonia to Understand the Pathogenesis of Conduction Aphasia
    ZHANG Yu-Mei;WANG Yong-Jun
    2011, 6(08):  599-604. 
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    Does Glial Cells Ischemia Exist in Cerebral Ischemia?
    ZHANG Wei-Wei;CHEN Fei;LI Ying
    2011, 6(08):  605-607. 
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    论著
    Investigation on the Causes of Semantic Category-specific Deficits:The Role of Object Manipulability
    WANG Xiao-Sha;WANG Xiao-Ying;HAN Zai-Zhu;et al
    2011, 6(08):  609-614. 
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    Objective To investigate the role of object manipulability in semantic category-specific deficits.Methods A brain-injured patient was tested in several tasks(Object decision, picture naming, word-picture verification, naming to definition, attribute judgment, word-word association matching) to assess the living-nonliving dissociation. Logistic regression analysis was conducted to study the role of object manipulability in categorical dissociation.Results In picture naming, word-picture verification, naming to definition and attribute judgment, the patient performed better at nonliving items than at living items(P<0.01). Logistic regression revealed that the predictive role of semantic category for naming accuracy was replaced by object manipulability after the latter was included in the equation(P<0.01).Conclusion The better performance at nonliving items at living items of the patient could be due to his preservation of manipulation knowledge about nonliving things.
    Effect of Kallikrein on Serum Matrix Metalloproteinase-9 (MMP-9) and its Clinical Efficacy in Patients with Capsular Warning Syndrome
    FU Sheng-Qi;ZHANG Shu-Ling;JI Peng;et al
    2011, 6(08):  615-619. 
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    Objective To investigate the effects of Kallikrein on serum matrix metalloproteinase-9(MMP-9) and its clinical efficacy in patients with stroke coming from capsular warning syndrome.Methods Thirty-one patients with stroke coming from capsular warning syndrome were randomly divided into control group(n=15) and treatment group(n=16). Each group was consistently given 14 days basical treatment, treatment group was given Kallikrein else. The serum levels of MMP-9 were detected before and after treatment. All patients' never function was assessed by National Institutes of Health Stroke Scale(NIHSS) and Barthel Index(BI) at admission and at 3 months after admission.Results Compared with that at admission, NIHSS decreased and BI increased at 3 months, there was statistical deference in two groups(each P<0.001), and treatment group has lower NIHSS and higher BI (P<0.001). After treatment, obvious decrease of serum MMP-9 concentration was seen in both groups comparing with non-treatment(each P<0.01), and treatment group was lower than control group(P<0.01).Conclusion Kallikrein can improve functional neurological recovery and reduce the serum level of MMP-9 in patients with stroke coming from capsular warning syndrome.
    Clinical and Image Manifestations of Spinal Dural Arteriovenous Fistula: Six Cases Study
    HU Hong-Tao;MA Zhi-Gang;YAN Li-Rong;et al
    2011, 6(08):  620-626. 
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    Objective To investigate the clinical and image feature of the spinal dural arteriovenous fistula (SDAVF) and to deepen the understanding of the disease.Methods Detailed clinical and image examinations were performed in all the 6 patients, who underwent spinal magnetic resonance imaging (MRI), selective spinal digital subtraction angiography (DSA). They all fulfilled the diagnostic criteria for the spinal dural arteriovenous fistula. Some of them accepted the therapy of embolism.Results Mean age was 49.3 years (27-65 years) and 5 were men. The spinal lesions were located in the segment of thorax and lumbar. Initial weakness and sensory changes were usually asymmetric (5 patients) and ascend from the lower extremities. Initial symptoms included leg sensory disturbances (3 patients), pain involving hip and legs (2 patients), leg weakness (2 patients). Sphincter disturbances were presented in all of the 6 patients. Five patients presented subacute or chronic period. Symptoms fluctuated in 4 of 6 patients. Spinal MRI showed the swelling and the abnormal signal in the spinal cord lesion. Persistent pathological vessels can be seen on MRI and be helpful for the diagnosis. DSA is the gold diagnostic standard for the disease when the dural arteriovenous fistula and arterialized draining vein are found. The sign level was not correlated with the image level in the all cases. Four of 6 patients accepted therapy of embolism, 1 patient failed to improve and 3 patients demonstrated delayed deterioration after a period of improvement due to recurrentfistulas.Conclusion SDAVF had its clinical and image features. Neuroimaging was useful in confirming the diagnosis. Thus, the spinal should be examined with MRI when a SDAVF is suspected. The therapy of embolism was relatively effective.
    Clinical Analysis of Cancer Patients Complicated by Pulmonary Embolism to Start with Syncope
    WANG Ji-Yun
    2011, 6(08):  627-631. 
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    Objective To analyse the clinical charateristics of cancers complicated by pulmonary embolism in order to detect pulmonary embolism early and start therapy early.Methods We enrolled 11 inpatient and outpatient department patients aged 31-85years old continuously from March, 2006 to January, 2011. All patients are diagnosed with cancers. All cancers are confirmed by pathological examination, lab tests, physical checkup and clinical presentations. Eight cases are diagnosed with pulmonary embolism by pulmonary ventilation/perfusion imaging, 3 cases are diagnosed by spiral computed tomographic pulmonary angiography. We analysed the contributed cancer etiology and their related clinical presentation.Results Mean age is 63±17 years old. Eight cases are male(81.8%), three cases are female(27.3%). Gastric cancer(27.3%), prostate cancer(18.2%), breast cancer(9.1%), ovarian cancer(18.2%), colon cancer(9.1%), pulmonary cancer(18.2%) are the most frequently seen cancers complicated by pulmoary embolism. Related clinical presentations are syncope(27.3%), orthostatic hypotension(27.3%), sinus tachycardia(18.2%), dyspnea(63.6%), chest pain(36.4%), leg and ankle edema(9.1%), anxiety and tension emotion(9.1%). All patients are anticoagulated fully by low molecular weight heparin and oral warfarin. Symptom disappeared and no patients died during the study.Conclusion Cancer is a very important risk factor for pulmonary embolism, especially the cancer types found in this study. Be aware of the symptoms found in the study in order to screen pulmonary embolism.【Key Words】 Neoplasms; Pulmonary embolism; Syncope; Hypotension, orthostatic
    Effects of Transcranial Magnetic Stimulation in Patients with Cerebral Infarction
    ZHANG Hong-Xia;LAI Zong-Li;GAO Jun-Hua;et al
    2011, 6(08):  632-635. 
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    Objective To investigate the effects of transcranial magnetic stimulation(TMS) in patients with cerebral infarction.Methods Sixty patients who suffered cerebral infarction were assigned to experiment group and control group(30 cases each group). Both groups received rehabilitation therapy. Experiment group received TMS. Ten days were one period of treatment. Fugl-Meyer scores, Barthel Index, National Institutes of Health Stroke Scale(NIHSS) scores were recorded before treatment and after treatment.Results NIHSS scores:experiment group decreased from 6.57±2.66 to 4.01±2.83, control group decreased from 6.29±3.00 to5.10±2.43; Barthel Index:experiment group increased from 47.33±14.31 to 60.83±18.53, control group increased from 45.50±13.91 to53.67±15.97; Fugl-Meyer scores:experiment group increased from 38.20±24.01 to 58.40±29.57, control group increased from 37.53 ±23.8 to 49.60±29.77. Before treatment, there was no statistic difference between two groups on NIHSS scores, Barthel Index and Fugl-Meyer scores(P>0.05). After treatment, there was significant difference between two groups on NIHSS scores, Barthel Index and Fugl-Meyer scores (P<0.01).Conclusion TMS can improve limb function in patients with cerebral infarction and increase the ability of daily living.
    Validation and Modification of the Essen Stroke Risk Scale in Stroke Patients of China
    FU Guang-Rong;YUAN Wei-Qiang;CHEN Pei-Hao;et al
    2011, 6(08):  636-642. 
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    Objective To retrospectively validate the prediction of the essen stroke risk score(ESRS) in non-atrial fibrillation patients with acute ischemic stroke hospitalized in a stroke unit of China, to modify it, and to investigate the prediction of the streamlined ESRS.Methods Five hundred and ten hospitalized patients with acute cerebral infarction were collected within 24 hours, and clinical follow-up were available in 468 cases after 12 months. The ESRS were analyzed in accordance with the follow-up results and were divided into recurrence group and the non-recurrence group. Basic demographic information and various risk factors were compared via statistical analysis in both groups. We modified the ESRS and validated the stroke recurrence rate of the ESRS with the streamlined ESRS.Results In recurrence group(N=201) and the non-recurrence group(N=267), four risk factors of ESRS, including hypertension(P=0.0010), other heart disease(P=0.0162), smoking(P=0.0220),and previous transient ischemic attack or ischemic stroke, (P=0.0000) had significant difference (P<0.05). Three other risk factors, age(P=0.2565), previous myocardial infarction(P=0.5072), peripheral arterial disease(P=0.1578), showed no significant difference between the two groups(P>0.05). The differences of recurrence rate in diabetic patient group and non-diabetic patient group closely reached to statistical significance(P=0.07). The area under receiver operating characteristic(ROC) curve of the streamlined ESRS predicting the recurrence rate of stroke was 0.645(95%CI:0.596~0.695) and the area under ROC curve of the complete ESRS was 0.650(95%CI:0.601~0.699). The difference was not statistically significant(P=0.8875>0.05).Conclusion In this study, the ESRS and the streamlined ESRS could predict the recurrence of stroke, which achieved similar prediction accuracies.
    专题论坛
    Somatosensory Event-Related Potentials N140: Basic Experiment and Clinical Research
    LIU Lin;ZHU Lin;FU Wei;et al
    2011, 6(08):  644-648. 
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    Current Diagnostic Situation of Depression in Patients with Poststroke Aphasia
    HAN Li-Kun;ZHANG Yu-Mei
    2011, 6(08):  649-653. 
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    病例讨论
    Recanalization of a Middle Cerebral Artery Chronic Total Occlusion: One Case Report
    LIU Juan;YAO Guo-En;JIANG Xiao-Hong;et al
    2011, 6(08):  654-658. 
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    指南与规范
    Guidelines for the Primary Prevention of Stroke. One Guideline for Healthcare ProfessionalsFrom the American Heart Association/American Stroke Association(Part 1)
    DU Wan-Liang;SUN Hai-Xin;JIA Qian;et al
    2011, 6(08):  659-664. 
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    综述
    Organization of Semantic Memory: Evidence from Category-specific Processing Patterns
    LIN Nan;BI Yan-Chao;HAN Zai-Zhu
    2011, 6(08):  665-670. 
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    Theories about object conceptual representation have been advanced greatly in the past decades by neuropsychological evidence of semantic category-specific deficit following brain damage. We here review the most recent corroborating evidence from the brain-imaging paradigm on brain-damaged as well as healthy populations. The current evidence indicates that sensory-motor modalities and/or semantic categories are possible constraints on the organization of conceptual information. And these modality or category-specific semantic subsystems might have structural and functional connectivities to other cognitive components such as sensory, motor and theory of mind.
    教学园地
    Training of Psychological Diathesis for Students Major in Cerebrovascular Disease
    YE Yu-Mei;WANG Dong-Mei;ZHU Xiu-Ying
    2011, 6(08):  671-673. 
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    Progress of Education in Neurological Interventional Radiology
    MA Ning;ZHU Xian-Jin;JIANG Wei-Jian
    2011, 6(08):  674-676. 
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